microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR629 Gene

Subcategory (RNA class) for MIR629 Gene

miRNA

Number of RNA Genes sources:

4 / 14

Aliases for MIR629 Gene

  • MicroRNA 629 2 3 5
  • Hsa-MiR-629-3p 166 177
  • Hsa-MiR-629-5p 166 177
  • MIMAT0003298 51
  • MIMAT0004810 51
  • Hsa-Mir-629 3
  • MI0003643 51
  • Mir-629 3
  • MIRN629 3
  • MIR629 2

External Ids for MIR629 Gene

Previous HGNC Symbols for MIR629 Gene

  • MIRN629

Previous GeneCards Identifiers for MIR629 Gene

  • GC15M068159
  • GC15M070371

Summaries for MIR629 Gene

Entrez Gene Summary for MIR629 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR629 Gene

MIR629 (MicroRNA 629) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR629 include Systemic Lupus Erythematosus and Endometriosis Of Ovary.

Additional gene information for MIR629 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR629 Gene

Genomics for MIR629 Gene

GeneHancer (GH) Regulatory Elements for MIR629 Gene

Promoters and enhancers for MIR629 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J070078 Enhancer 0.9 ENCODE 500.7 +0.3 260 2.3 FOXK2 NCOR1 ZIC2 KDM6A TCF7 ZBTB25 TGIF2 SKI TEAD1 ZBTB26 MIR629 LOC105370877 TLE3 HSALNG0106894
GH15J070503 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.5 -427.3 -427268 7.1 ZNF217 ZSCAN5C TCF12 SP1 JUND FOS ZNF639 ZNF10 ZIC2 ZBTB10 LINC02205 lnc-LRRC49-17 TLE3 ENSG00000212664 MIR629 LINC02204
GH15J070194 Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 -118.6 -118626 7 ZNF217 ZSCAN5C POLR2G SP1 NCOR1 JUND TEAD4 FOS ZNF639 ZNF10 ENSG00000259252 TLE3 MIR629 RNU6-745P RF00026-367
GH15J070492 Enhancer 1.6 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 10.3 -414.5 -414544 5.3 ZNF217 ZSCAN5C TCF12 SP1 RBAK JUND FOS ZNF639 ZNF10 EP300 LRRC49 TLE3 THAP10 ENSG00000212664 MIR629 LINC02205 RF00017-1827 LINC02204
GH15J069712 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.2 +357.5 357467 20 CTCF USF1 SP1 EP300 ZIC2 REST RELA CUX1 RCOR1 RAD21 lnc-TLE3-16 TLE3 MIR629 lnc-RPLP1-6 lnc-TLE3-15 DRAIC LINC00593 PCAT29
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR629 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR629 Gene

Genomic Locations for MIR629 Gene
chr15:70,079,372-70,079,468
(GRCh38/hg38)
Size:
97 bases
Orientation:
Minus strand
chr15:70,371,711-70,371,807
(GRCh37/hg19)
Size:
97 bases
Orientation:
Minus strand

Genomic View for MIR629 Gene

Genes around MIR629 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR629 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR629 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR629 Gene

Proteins for MIR629 Gene

Post-translational modifications for MIR629 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR629 Gene

Domains & Families for MIR629 Gene

Gene Families for MIR629 Gene

HGNC:
genes like me logo Genes that share domains with MIR629: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR629 Gene

Function for MIR629 Gene

Phenotypes From GWAS Catalog for MIR629 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR629 Gene

Localization for MIR629 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR629 gene
Compartment Confidence
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR629 Gene

Pathways & Interactions for MIR629 Gene

PathCards logo

SuperPathways for MIR629 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR629 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR629 Gene

Drugs & Compounds for MIR629 Gene

No Compound Related Data Available

Transcripts for MIR629 Gene

mRNA/cDNA for MIR629 Gene

3 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
5 ENA transcripts :
2 LncBase transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR629 Gene

No ASD Table

Relevant External Links for MIR629 Gene

GeneLoc Exon Structure for
MIR629

Expression for MIR629 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR629 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR629

genes like me logo Genes that share expression patterns with MIR629: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR629 Gene

Orthologs for MIR629 Gene

Evolution for MIR629 Gene

ENSEMBL:
Gene Tree for MIR629 (if available)
TreeFam:
Gene Tree for MIR629 (if available)

No data available for Orthologs for MIR629 Gene

Paralogs for MIR629 Gene

No data available for Paralogs for MIR629 Gene

Variants for MIR629 Gene

Additional dbSNP identifiers (rs#s) for MIR629 Gene

Additional Variant Information for MIR629 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR629

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR629 Gene

Disorders for MIR629 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR629 Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
systemic lupus erythematosus
  • sle
endometriosis of ovary
  • ovarian endometriosis
leukorrhea
  • discharge - leukorrhea
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR629

genes like me logo Genes that share disorders with MIR629: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR629 Gene

Publications for MIR629 Gene

  1. MicroRNA‑629 inhibition suppresses the viability and invasion of non‑small cell lung cancer cells by directly targeting RUNX3. (PMID: 30816536) Zhuang B … Cheng Y (Molecular medicine reports 2019) 3 54
  2. MiR-629-5p promotes colorectal cancer progression through targetting CXXC finger protein 4. (PMID: 30042169) Lu J … Li Q (Bioscience reports 2018) 3 54
  3. Serum miR-629 is a novel molecular marker for diagnosis and the prognosis of pancreatic cancer. (PMID: 30178840) Shi W … Liu G (European review for medical and pharmacological sciences 2018) 3 54
  4. MiR-629 promotes human pancreatic cancer progression by targeting FOXO3. (PMID: 29072689) Yan H … Wu C (Cell death & disease 2017) 3 54
  5. Knockdown of miR-629 Inhibits Ovarian Cancer Malignant Behaviors by Targeting Testis-Specific Y-Like Protein 5. (PMID: 28972400) Shao L … Chen Y (DNA and cell biology 2017) 3 54

Products for MIR629 Gene

Sources for MIR629 Gene