microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR628 Gene

RNA type for MIR628 Gene

miRNA

Aliases for MIR628 Gene

External Ids for MIR628 Gene

Previous HGNC Symbols for MIR628 Gene

  • MIRN628

Previous GeneCards Identifiers for MIR628 Gene

  • GC15M053453
  • GC15M055665
  • GC15M055480
  • GC15M055481

Summaries for MIR628 Gene

Entrez Gene Summary for MIR628 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR628 Gene

MIR628 (MicroRNA 628) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR628 include Squamous Cell Carcinoma, Head And Neck and Mild Pre-Eclampsia.

Rfam classification for MIR628 Gene

Additional gene information for MIR628 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR628 Gene

Genomics for MIR628 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR628 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J055372 Promoter/Enhancer 0.9 EPDnew Ensembl 250.7 -0.1 -67 1.4 FOXA1 FOXA2 PRDM6 ZNF664 PKNOX1 SPI1 MTA2 RELB MIR628 CCPG1 C15orf65 piR-50437-217 PIGBOS1 DNAAF4-CCPG1
GH15J055394 Enhancer 1 Ensembl ENCODE 13.1 -22.4 -22367 4.4 NCOR1 IKZF1 ZNF592 CEBPB HES1 TBP MNT NFATC3 NBN NKRF DNAAF4 MIR628 C15orf65 CCPG1 PIGB RF00017-1607 PIGBOS1 DNAAF4-CCPG1
GH15J055344 Enhancer 0.8 Ensembl ENCODE 12 +28.9 28891 2.1 FEZF1 ZNF843 TAL1 PRDM6 ZNF384 SP7 CEBPB CHD2 GFI1B BCL11A ENSG00000274765 PIGB MIR628 C15orf65 ENSG00000277548 PIGBOS1 lnc-PIGBOS1-3 RAB27A CCPG1
GH15J055417 Enhancer 0.5 Ensembl 11.3 -45.1 -45067 1 KLF7 GLIS1 ZNF398 KLF1 PATZ1 IKZF1 piR-53338-046 MIR628 PIGB C15orf65 CCPG1 HSALNG0106073 piR-52079-065 DNAAF4-CCPG1 DNAAF4
GH15J055326 Enhancer 0.3 Ensembl 12.1 +45.7 45733 1.4 SPI1 ZBTB33 PIGB MIR628 RAB27A DNAAF4 HSALNG0106066 ENSG00000274765 PIGBOS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR628 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR628 Gene

Latest Assembly
chr15:55,372,940-55,373,034
(GRCh38/hg38)
Size:
95 bases
Orientation:
Minus strand

Previous Assembly
chr15:55,665,138-55,665,232
(GRCh37/hg19 by Entrez Gene)
Size:
95 bases
Orientation:
Minus strand

Genomic View for MIR628 Gene

Genes around MIR628 on UCSC Golden Path with GeneCards custom track
MIR628 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR628 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR628 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR628 Gene

Proteins for MIR628 Gene

Post-translational modifications for MIR628 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR628 Gene

Domains & Families for MIR628 Gene

Gene Families for MIR628 Gene

HGNC:
genes like me logo Genes that share domains with MIR628: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR628 Gene

Function for MIR628 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR628 Gene

Localization for MIR628 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR628 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1

Gene Ontology (GO) - Cellular Components for MIR628 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR628: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR628 Gene

Pathways & Interactions for MIR628 Gene

PathCards logo

SuperPathways for MIR628 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR628 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR628: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR628 Gene

Drugs & Compounds for MIR628 Gene

No Compound Related Data Available

Transcripts for MIR628 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR628 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00004B83FE_9606 miRNA 22 6

RefSeq: NR_030358,

LncBase: hsa-miR-628-5p,

miRBase: MIMAT0004809,

MirGeneDB: Hsa-Mir-628_5p,

TarBase: hsa-miR-628-5p,

ENA: LM380418.1:1..22:ncRNA, LM609581.1:23..44:ncRNA,

URS000050D31F_9606 pre_miRNA 95 5

RefSeq: NR_030358,

Ensembl: ENST00000385229 (view in UCSC) ,

miRBase: MI0003642,

Rfam: RF01012,

ENA: LM609581.1:1..95:precursor_RNA,

URS000061BE3B_9606 miRNA 21 5

RefSeq: NR_030358,

LncBase: hsa-miR-628-3p,

miRBase: MIMAT0003297,

TarBase: hsa-miR-628-3p,

ENA: LM379879.1:1..21:ncRNA, LM609581.1:61..81:ncRNA,

URS0001BBFDDF_9606 pre_miRNA 95 1

Rfam: RF01012,

URS0000EFD359_9606 pre_miRNA 62 1

MirGeneDB: Hsa-Mir-628,

MIR628 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR628 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR628 Gene

No ASD Table

Relevant External Links for MIR628 Gene

GeneLoc Exon Structure for
MIR628

Expression for MIR628 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR628 Gene

mRNA differential expression in normal tissues according to GTEx for MIR628 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x9.1), Brain - Cerebellum (x7.3), Brain - Cortex (x6.4), Brain - Nucleus accumbens (basal ganglia) (x5.3), and Brain - Anterior cingulate cortex (BA24) (x4.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR628

genes like me logo Genes that share expression patterns with MIR628: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR628 Gene

Orthologs for MIR628 Gene

Evolution for MIR628 Gene

ENSEMBL:
Gene Tree for MIR628 (if available)
TreeFam:
Gene Tree for MIR628 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR628

No data available for Orthologs for MIR628 Gene

Paralogs for MIR628 Gene

No data available for Paralogs for MIR628 Gene

Variants for MIR628 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR628 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR628 Gene

Variant ID Type Subtype PubMed ID
esv2761899 CNV gain+loss 21179565
esv3569598 CNV gain 25503493
nsv1043789 CNV gain 25217958
nsv520799 CNV loss 19592680
nsv569523 CNV gain 21841781

Additional Variant Information for MIR628 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR628
Leiden Open Variation Database (LOVD)
MIR628

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR628 Gene

Disorders for MIR628 Gene

MalaCards: The human disease database

(7) MalaCards diseases for MIR628 Gene - From: MID and COP

Disorder Aliases PubMed IDs
squamous cell carcinoma, head and neck
  • hnscc
mild pre-eclampsia
  • mild toxemia
lung cancer
  • lung cancer, susceptibility to
endocrine system disease
  • abnormality of the endocrine system
respiratory system disease
  • abnormality of the respiratory system
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR628

genes like me logo Genes that share disorders with MIR628: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR628 Gene

Publications for MIR628 Gene

  1. miR-628-3p regulates osteoblast differentiation by targeting RUNX2: Possible role in atrophic non-union. (PMID: 28035362) Chen H … Tang P (International journal of molecular medicine 2017) 2 3
  2. Circulatory miR-628-5p is downregulated in prostate cancer patients. (PMID: 24477576) Srivastava A … Kumar D (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014) 2 3
  3. Identification of regulatory mRNA and microRNA for differentiation into cementoblasts and periodontal ligament cells. (PMID: 32797637) Iwata T … Kurihara H (Journal of periodontal research 2021) 3
  4. miR-628-5p promotes growth and migration of osteosarcoma by targeting IFI44L. (PMID: 31018104) Wang JY … Lu SB (Biochemistry and cell biology = Biochimie et biologie cellulaire 2020) 3
  5. MicroRNA-628-5p inhibits invasion and migration of human pancreatic ductal adenocarcinoma via suppression of the AKT/NF-kappa B pathway. (PMID: 31957029) Zhou L … Zhang L (Journal of cellular physiology 2020) 3

Products for MIR628 Gene

Sources for MIR628 Gene