microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR625 Gene

Subcategory (RNA class) for MIR625 Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR625 Gene

  • MIMAT0004808 50
  • MIMAT0003294 50
  • MI0003639 50
  • MIRN625 3
  • RF00027 168

External Ids for MIR625 Gene

Previous HGNC Symbols for MIR625 Gene

  • MIRN625

Previous GeneCards Identifiers for MIR625 Gene

  • GC14P065008
  • GC14P065937

Summaries for MIR625 Gene

Entrez Gene Summary for MIR625 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR625 Gene

MIR625 (MicroRNA 625) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR625 include Pleural Cancer and Pleural Disease. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR625 Gene

Additional gene information for MIR625 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR625 Gene

Genomics for MIR625 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR625 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J065469 Enhancer 0.8 Ensembl ENCODE 600.7 -0.3 -301 4 RELA NR2C1 EED RUNX3 FOXA2 NR2C2 JUNB NR2F1 PRDM4 ZNF384 MIR625 RF00027 FUT8 RPL21P8 CCDC196
GH14J065410 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.3 -57.6 -57628 5.1 SP1 HNRNPL CREB1 CTCF TEAD4 PRDM10 IKZF1 NFKBIZ POLR2A BACH1 FUT8 FUT8-AS1 lnc-FNTB-4 RPL21P8 MIR625 CCDC196
GH14J065438 Enhancer 0.8 Ensembl ENCODE 11.2 -33.2 -33202 3.4 EP300 RUNX3 HDAC2 FOSL1 NCOR1 NFIC ZNF592 TAL1 NFIB ZNF18 MIR625 RPL21P8 FUT8 hsa-miR-5095-134 lnc-FNTB-4 piR-60898-008 CCDC196
GH14J065506 Enhancer 0.8 Ensembl ENCODE 11.2 +35.9 35864 0.3 GATAD2A SOX13 FOXA2 FOXP1 POLR2A FOXA1 SMAD4 BCL6 TFAP4 RARA MIR625 RPL21P8 EIF1AXP2 lnc-MAX-13 RF00027 FUT8 CCDC196
GH14J065430 Enhancer 0.7 ENCODE 11.2 -38.0 -38035 4.2 FOXA1 PKNOX1 HDAC1 HMBOX1 RELB ESR1 ZSCAN29 GATA3 ZNF592 ZNF584 FUT8 MIR625 RPL21P8 hsa-miR-5095-134 lnc-FNTB-4 piR-60898-008 CCDC196
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR625 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR625 Gene

Genomic Locations for MIR625 Gene
chr14:65,471,102-65,471,186
(GRCh38/hg38)
Size:
85 bases
Orientation:
Plus strand
chr14:65,937,820-65,937,904
(GRCh37/hg19)
Size:
85 bases
Orientation:
Plus strand

Genomic View for MIR625 Gene

Genes around MIR625 on UCSC Golden Path with GeneCards custom track
MIR625 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR625 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR625 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR625 Gene

Proteins for MIR625 Gene

Post-translational modifications for MIR625 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR625 Gene

Domains & Families for MIR625 Gene

Gene Families for MIR625 Gene

HGNC:
genes like me logo Genes that share domains with MIR625: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR625 Gene

Function for MIR625 Gene

Phenotypes From GWAS Catalog for MIR625 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR625 Gene

Localization for MIR625 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR625 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR625 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR625: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR625 Gene

Pathways & Interactions for MIR625 Gene

PathCards logo

SuperPathways for MIR625 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR625: view

Pathways by source for MIR625 Gene

1 KEGG pathway for MIR625 Gene

Gene Ontology (GO) - Biological Process for MIR625 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR625: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR625 Gene

Drugs & Compounds for MIR625 Gene

No Compound Related Data Available

Transcripts for MIR625 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR625 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000001A7A_9606 precursor_RNA 85 5

HGNC: 32881,

RefSeq: NR_030355,

Ensembl: ENST00000385047 (view in UCSC) ,

miRBase: MI0003639,

ENA: HI486120.1:1..85:misc_RNA, LM609579.1:1..85:precursor_RNA,

URS0000475E09_9606 miRNA 22 5

RefSeq: NR_030355,

LncBase: hsa-miR-625-3p,

miRBase: MIMAT0004808,

TarBase: hsa-miR-625-3p,

ENA: LM380417.1:1..22:ncRNA, LM609579.1:52..73:ncRNA,

URS00001F9866_9606 miRNA 21 5

RefSeq: NR_030355,

LncBase: hsa-miR-625-5p,

miRBase: MIMAT0003294,

TarBase: hsa-miR-625-5p,

ENA: LM379877.1:1..21:ncRNA, LM609579.1:15..35:ncRNA,

URS000070C832_9606 precursor_RNA 73 1

Rfam: RF00027,

MIR625 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR625 Gene

No ASD Table

Relevant External Links for MIR625 Gene

GeneLoc Exon Structure for
MIR625

No data available for mRNA/cDNA for MIR625 Gene

Expression for MIR625 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR625

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR625 Gene

Orthologs for MIR625 Gene

Evolution for MIR625 Gene

ENSEMBL:
Gene Tree for MIR625 (if available)
TreeFam:
Gene Tree for MIR625 (if available)

No data available for Orthologs for MIR625 Gene

Paralogs for MIR625 Gene

No data available for Paralogs for MIR625 Gene

Variants for MIR625 Gene

Additional dbSNP identifiers (rs#s) for MIR625 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR625 Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV deletion 23290073
nsv976347 CNV duplication 23825009

Additional Variant Information for MIR625 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR625

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR625 Gene

Disorders for MIR625 Gene

MalaCards: The human disease database

(14) MalaCards diseases for MIR625 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pleural cancer
  • neoplasm of pleura
pleural disease
  • disorder of pleura
malignant pleural mesothelioma
  • malignant mesothelioma of pleura
papillary serous adenocarcinoma
  • micropapillary serous carcinoma
rectum cancer
  • cancer of rectum
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR625

genes like me logo Genes that share disorders with MIR625: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR625 Gene

Publications for MIR625 Gene

  1. miR‑625‑5p suppresses inflammatory responses by targeting AKT2 in human bronchial epithelial cells. (PMID: 30628701) Qian FH … Zheng DD (Molecular medicine reports 2019) 3
  2. MicroRNA-625 inhibits the progression of non‑small cell lung cancer by directly targeting HOXB5 and deactivating the Wnt/β-catenin pathway. (PMID: 31115501) Tan X … Lin Q (International journal of molecular medicine 2019) 3
  3. Circulating miR-625 as an Emerging Biomarker for Liver Cirrhosis. (PMID: 30969085) Ghaempoor M … Hatami B (Clinical laboratory 2019) 3
  4. Hypoxia-associated circDENND2A promotes glioma aggressiveness by sponging miR-625-5p. (PMID: 30988674) Su H … Dai Y (Cellular & molecular biology letters 2019) 3
  5. MicroRNA-625 inhibits cell invasion and epithelial-mesenchymal transition by targeting SOX4 in laryngeal squamous cell carcinoma. (PMID: 30563928) Li Y … Zhou X (Bioscience reports 2019) 3

Products for MIR625 Gene

Sources for MIR625 Gene