microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR621 Gene

Subcategory (RNA class) for MIR621 Gene

miRNA

Number of RNA Genes sources:

4 / 17

Aliases for MIR621 Gene

  • MicroRNA 621 2 3 5
  • Hsa-Mir-621 2 3
  • Hsa-MiR-621 163 173
  • MIR621 2 5
  • MIMAT0003290 50
  • MI0003635 50
  • MIRN621 3
  • RF02008 168

External Ids for MIR621 Gene

Previous HGNC Symbols for MIR621 Gene

  • MIRN621

Previous GeneCards Identifiers for MIR621 Gene

  • GC13P040283
  • GC13P041384

Summaries for MIR621 Gene

Entrez Gene Summary for MIR621 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR621 Gene

MIR621 (MicroRNA 621) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR621 include Sarcomatosis.

Rfam classification for MIR621 Gene

Additional gene information for MIR621 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR621 Gene

Genomics for MIR621 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR621 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J040811 Enhancer 0.7 Ensembl ENCODE 600.7 +1.7 1735 4.2 CTCF RAD21 RELB SMC3 TEAD1 FOS XRCC5 ELF3 SPI1 IKZF1 MIR621 piR-55425 SLC25A15 WBP4 piR-46002-144 TPTE2P5 lnc-ELF1-1 ELF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR621 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR621 Gene

Genomic Locations for MIR621 Gene
chr13:40,810,766-40,810,861
(GRCh38/hg38)
Size:
96 bases
Orientation:
Plus strand
chr13:41,384,902-41,384,997
(GRCh37/hg19)
Size:
96 bases
Orientation:
Plus strand

Genomic View for MIR621 Gene

Genes around MIR621 on UCSC Golden Path with GeneCards custom track
MIR621 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR621 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR621 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR621 Gene

Proteins for MIR621 Gene

Post-translational modifications for MIR621 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR621 Gene

Domains & Families for MIR621 Gene

Gene Families for MIR621 Gene

HGNC:
genes like me logo Genes that share domains with MIR621: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR621 Gene

Function for MIR621 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR621 Gene

Localization for MIR621 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR621 gene
Compartment Confidence
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR621 Gene

Pathways & Interactions for MIR621 Gene

PathCards logo

SuperPathways for MIR621 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR621 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR621: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR621 Gene

Drugs & Compounds for MIR621 Gene

No Compound Related Data Available

Transcripts for MIR621 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR621 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00006D8030_9606 precursor_RNA 96 5

HGNC: 32877,

RefSeq: NR_030352,

Ensembl: ENST00000384919 (view in UCSC) ,

miRBase: MI0003635,

Rfam: RF02008,

URS000075E0A8_9606 miRNA 21 4

RefSeq: NR_030352,

LncBase: hsa-miR-621,

miRBase: MIMAT0003290,

TarBase: hsa-miR-621,

MIR621 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR621 Gene

No ASD Table

Relevant External Links for MIR621 Gene

GeneLoc Exon Structure for
MIR621

No data available for mRNA/cDNA for MIR621 Gene

Expression for MIR621 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR621 Gene

mRNA differential expression in normal tissues according to GTEx for MIR621 Gene

This gene is overexpressed in Liver (x15.3) and Pancreas (x6.2).
genes like me logo Genes that share expression patterns with MIR621: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR621 Gene

Orthologs for MIR621 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR621 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-621 31
  • 99 (a)
OneToOne
Species where no ortholog for MIR621 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR621 Gene

ENSEMBL:
Gene Tree for MIR621 (if available)
TreeFam:
Gene Tree for MIR621 (if available)

Paralogs for MIR621 Gene

No data available for Paralogs for MIR621 Gene

Variants for MIR621 Gene

Additional dbSNP identifiers (rs#s) for MIR621 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR621 Gene

Variant ID Type Subtype PubMed ID
esv3892332 CNV gain 25118596

Additional Variant Information for MIR621 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR621

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR621 Gene

Disorders for MIR621 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR621 Gene - From: DISEASES

Disorder Aliases PubMed IDs
sarcomatosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR621

genes like me logo Genes that share disorders with MIR621: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR621 Gene

Publications for MIR621 Gene

  1. MiRNA-621 sensitizes breast cancer to chemotherapy by suppressing FBXO11 and enhancing p53 activity. (PMID: 25867061) Xue J … Wu J (Oncogene 2016) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3
  3. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 3

Products for MIR621 Gene

Sources for MIR621 Gene