microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR620 Gene

Subcategory (RNA class) for MIR620 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR620 Gene

  • MicroRNA 620 2 3 5
  • MIMAT0003289 53
  • Hsa-Mir-620 3
  • MI0003634 53
  • MIRN620 3
  • MIR620 2

External Ids for MIR620 Gene

Previous HGNC Symbols for MIR620 Gene

  • MIRN620

Previous GeneCards Identifiers for MIR620 Gene

  • GC12U901028
  • GC12M115072
  • GC12M116586

Summaries for MIR620 Gene

Entrez Gene Summary for MIR620 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR620 Gene

MIR620 (MicroRNA 620) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR620 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR620 Gene

Genomics for MIR620 Gene

GeneHancer (GH) Regulatory Elements for MIR620 Gene

Promoters and enhancers for MIR620 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J116148 Enhancer 0.4 ENCODE 750.6 -0.6 -648 0.8 RUNX3 JUN PRDM6 MIR620 SNRPGP18 lnc-MAP1LC3B2-10 MED13L lnc-C12orf49-6
GH12J116121 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 11.5 +25.8 25806 3.5 SIN3A SMARCE1 MYC CC2D1A ETV6 HLF MAX DACH1 MNT TEAD4 MAP1LC3B2 FBXW8 MED13L MIR620 ENSG00000258034 RF00026-268 RNU6-1188P lnc-C12orf49-6
GH12J116236 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.7 -93.9 -93947 14.4 ZBTB40 CTCF ZNF362 MIXL1 DACH1 ZNF121 RAD21 TEAD4 MLLT1 CBFA2T2 MIR620 lnc-C12orf49-6 MED13L ENSG00000258337
GH12J116171 Enhancer 0.9 ENCODE dbSUPER 11.5 -23.7 -23689 1.4 SMARCE1 ZNF362 ETV6 TEAD4 PRDM1 CREM ZBED1 PKNOX1 HDAC1 EP300 MIR620 SNRPGP18 lnc-MAP1LC3B2-10 ENSG00000258337 lnc-C12orf49-6 MED13L
GH12J116071 Enhancer 0.8 Ensembl dbSUPER 10.8 +75.1 75054 7.2 ZNF384 MAFK ZNF680 CEBPG PKNOX1 CEBPB ZNF316 OSR2 ZNF580 GATA3 MIR620 RF00026-268 RNU6-1188P piR-57461-053 MED13L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR620 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR620 Gene

Genomic Locations for MIR620 Gene
chr12:116,148,560-116,148,654
(GRCh38/hg38)
Size:
95 bases
Orientation:
Minus strand
chr12:116,586,365-116,586,459
(GRCh37/hg19)
Size:
95 bases
Orientation:
Minus strand

Genomic View for MIR620 Gene

Genes around MIR620 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR620 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR620 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR620 Gene

Proteins for MIR620 Gene

Post-translational modifications for MIR620 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR620 Gene

Domains & Families for MIR620 Gene

Gene Families for MIR620 Gene

HGNC:
genes like me logo Genes that share domains with MIR620: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR620 Gene

Function for MIR620 Gene

Phenotypes From GWAS Catalog for MIR620 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR620 Gene

Localization for MIR620 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR620 Gene

Pathways & Interactions for MIR620 Gene

PathCards logo

SuperPathways for MIR620 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR620 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR620 Gene

Drugs & Compounds for MIR620 Gene

No Compound Related Data Available

Transcripts for MIR620 Gene

mRNA/cDNA for MIR620 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNACentral transcripts :
(2) miRBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR620 Gene

No ASD Table

Relevant External Links for MIR620 Gene

GeneLoc Exon Structure for
MIR620
ECgene alternative splicing isoforms for
MIR620

Expression for MIR620 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR620 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR620 Gene:

MIR620
genes like me logo Genes that share expression patterns with MIR620: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR620 Gene

Orthologs for MIR620 Gene

Evolution for MIR620 Gene

ENSEMBL:
Gene Tree for MIR620 (if available)
TreeFam:
Gene Tree for MIR620 (if available)

No data available for Orthologs for MIR620 Gene

Paralogs for MIR620 Gene

No data available for Paralogs for MIR620 Gene

Variants for MIR620 Gene

Sequence variations from dbSNP and Humsavar for MIR620 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1002942589 -- 116,148,129(-) T/C downstream_transcript_variant
rs1003719367 -- 116,149,806(-) T/C upstream_transcript_variant
rs1005059505 -- 116,148,262(-) G/A downstream_transcript_variant
rs1005379971 -- 116,150,020(-) G/A upstream_transcript_variant
rs1005459625 -- 116,148,607(-) A/G non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR620 Gene

Variant ID Type Subtype PubMed ID
nsv832522 CNV loss 17160897
nsv952488 CNV duplication 24416366

Additional Variant Information for MIR620 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR620

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR620 Gene

Disorders for MIR620 Gene

Additional Disease Information for MIR620

No disorders were found for MIR620 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR620 Gene

Publications for MIR620 Gene

  1. GPC5, a tumor suppressor, is regulated by miR-620 in lung adenocarcinoma. (PMID: 24682381) Zhao Z … Cheng L (Molecular medicine reports 2014) 3 56
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 56
  3. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 56

Products for MIR620 Gene

Sources for MIR620 Gene