microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR618 Gene

Subcategory (RNA class) for MIR618 Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR618 Gene

  • MicroRNA 618 2 3 5
  • Hsa-MiR-618 168 179
  • MIMAT0003287 53
  • Hsa-Mir-618 3
  • MI0003632 53
  • Mir-618 3
  • MIRN618 3
  • RF01034 174
  • MIR618 2

External Ids for MIR618 Gene

Previous HGNC Symbols for MIR618 Gene

  • MIRN618

Previous GeneCards Identifiers for MIR618 Gene

  • GC12M079854
  • GC12M081329

Summaries for MIR618 Gene

Entrez Gene Summary for MIR618 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR618 Gene

MIR618 (MicroRNA 618) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR618 Gene

Additional gene information for MIR618 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR618 Gene

Genomics for MIR618 Gene

GeneHancer (GH) Regulatory Elements for MIR618 Gene

Promoters and enhancers for MIR618 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J080936 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 0.6 -2.1 -2068 5 ZBTB6 MYC RAD21 ELF3 SP1 ZNF384 CEBPG TFE3 PRDM1 PPARG LIN7A ACSS3 LOC105369869 MIR618
GH12J080922 Enhancer 0.7 Ensembl ENCODE 0.4 +11.9 11887 3.1 NR2F6 HLF GATAD2A RXRB FOXA2 FOXA1 RARA HNF4A ACSS3 MIR618 LIN7A lnc-PPFIA2-4 ENSG00000258215
GH12J080893 Enhancer 0.7 Ensembl ENCODE 0.3 +42.4 42432 3.6 IKZF1 BACH1 IKZF2 DPF2 BCL11A RUNX3 NR2F1 JUNB BATF FOS LIN7A ENSG00000258215 lnc-PPFIA2-4 MIR618
GH12J080867 Enhancer 0.7 ENCODE 0.2 +67.4 67402 2.2 GATA3 TCF7L2 ZNF217 NCOA3 CREB1 GATAD2B TARDBP CTBP1 BMI1 ZNF592 LIN7A ENSG00000258215 lnc-PPFIA2-4 MIR618
GH12J080877 Enhancer 0.6 FANTOM5 Ensembl 0.2 +58.0 58032 0.4 SP1 YY1 NR2F2 RXRA LIN7A lnc-PPFIA2-4 ENSG00000258215 MIR618
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR618 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR618 Gene

Genomic Locations for MIR618 Gene
chr12:80,935,735-80,935,833
(GRCh38/hg38)
Size:
99 bases
Orientation:
Minus strand
chr12:81,329,515-81,329,612
(GRCh37/hg19)
Size:
98 bases
Orientation:
Minus strand

Genomic View for MIR618 Gene

Genes around MIR618 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR618 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR618 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR618 Gene

Proteins for MIR618 Gene

Post-translational modifications for MIR618 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR618 Gene

Domains & Families for MIR618 Gene

Gene Families for MIR618 Gene

HGNC:
genes like me logo Genes that share domains with MIR618: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR618 Gene

Function for MIR618 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR618 Gene

Localization for MIR618 Gene

Gene Ontology (GO) - Cellular Components for MIR618 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR618: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR618 Gene

Pathways & Interactions for MIR618 Gene

PathCards logo

SuperPathways for MIR618 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR618 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR618: view

No data available for Pathways by source and SIGNOR curated interactions for MIR618 Gene

Drugs & Compounds for MIR618 Gene

No Compound Related Data Available

Transcripts for MIR618 Gene

mRNA/cDNA for MIR618 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNACentral transcripts :
(2) miRBase transcripts :
(3) ENA transcripts :
(1) LncBase transcripts :
(1) TarBase transcripts :
(1) Rfam transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR618 Gene

No ASD Table

Relevant External Links for MIR618 Gene

GeneLoc Exon Structure for
MIR618
ECgene alternative splicing isoforms for
MIR618

Expression for MIR618 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR618 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR618 Gene:

MIR618
genes like me logo Genes that share expression patterns with MIR618: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR618 Gene

Orthologs for MIR618 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR618 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-618 33
  • 99 (a)
OneToOne
Species where no ortholog for MIR618 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR618 Gene

ENSEMBL:
Gene Tree for MIR618 (if available)
TreeFam:
Gene Tree for MIR618 (if available)

Paralogs for MIR618 Gene

No data available for Paralogs for MIR618 Gene

Variants for MIR618 Gene

Sequence variations from dbSNP and Humsavar for MIR618 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1002068716 -- 80,935,948(-) G/A upstream_transcript_variant
rs1002098422 -- 80,936,208(-) G/C upstream_transcript_variant
rs1003741723 -- 80,937,405(-) C/T upstream_transcript_variant
rs1004217207 -- 80,936,298(-) C/T upstream_transcript_variant
rs1004478224 -- 80,935,382(-) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR618 Gene

Variant ID Type Subtype PubMed ID
esv3580346 CNV loss 25503493
nsv789 CNV deletion 18451855

Additional Variant Information for MIR618 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR618

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR618 Gene

Disorders for MIR618 Gene

Additional Disease Information for MIR618

No disorders were found for MIR618 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR618 Gene

Publications for MIR618 Gene

  1. Increased Expression of Circular RNA circ_0005230 Indicates Dismal Prognosis in Breast Cancer and Regulates Cell Proliferation and Invasion via miR-618/ CBX8 Signal Pathway. (PMID: 30504704) Xu Y … Cui Y (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018) 3 56
  2. Polymorphism rs2682818 in miR-618 is associated with colorectal cancer susceptibility in a Han Chinese population. (PMID: 29533012) Chen Y … Chen J (Cancer medicine 2018) 3 56
  3. Association of MicroRNA-618 Expression With Altered Frequency and Activation of Plasmacytoid Dendritic Cells in Patients With Systemic Sclerosis. (PMID: 28556560) Rossato M … Radstake TRDJ (Arthritis & rheumatology (Hoboken, N.J.) 2017) 3 56
  4. MicroRNA-618 modulates cell growth via targeting PI3K/Akt pathway in human thyroid carcinomas. (PMID: 27453421) Yi L … Yuan Y (Indian journal of cancer 2015) 3 56
  5. Targetome profiling and functional genetics implicate miR-618 in lymphomagenesis. (PMID: 24503492) Fu A … Zhu Y (Epigenetics 2014) 3 56

Products for MIR618 Gene

Sources for MIR618 Gene