microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR616 Gene

Subcategory (RNA class) for MIR616 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR616 Gene

  • MIMAT0003284 50
  • MIMAT0004805 50
  • MI0003629 50
  • MIRN616 3
  • RF00995 168

External Ids for MIR616 Gene

Previous HGNC Symbols for MIR616 Gene

  • MIRN616

Previous GeneCards Identifiers for MIR616 Gene

  • GC12M056200
  • GC12M057912

Summaries for MIR616 Gene

Entrez Gene Summary for MIR616 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR616 Gene

MIR616 (MicroRNA 616) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR616 include Spinal Disease.

Rfam classification for MIR616 Gene

Additional gene information for MIR616 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR616 Gene

Genomics for MIR616 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR616 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR616 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR616 Gene

Genomic Locations for MIR616 Gene
chr12:57,519,163-57,519,259
(GRCh38/hg38)
Size:
97 bases
Orientation:
Minus strand
chr12:57,912,946-57,913,042
(GRCh37/hg19)
Size:
97 bases
Orientation:
Minus strand

Genomic View for MIR616 Gene

Genes around MIR616 on UCSC Golden Path with GeneCards custom track
MIR616 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR616 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR616 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR616 Gene

Proteins for MIR616 Gene

Post-translational modifications for MIR616 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR616 Gene

Domains & Families for MIR616 Gene

Gene Families for MIR616 Gene

HGNC:
genes like me logo Genes that share domains with MIR616: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR616 Gene

Function for MIR616 Gene

Phenotypes From GWAS Catalog for MIR616 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR616 Gene

Localization for MIR616 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR616 Gene

Pathways & Interactions for MIR616 Gene

PathCards logo

SuperPathways for MIR616 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR616 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR616: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR616 Gene

Drugs & Compounds for MIR616 Gene

No Compound Related Data Available

Transcripts for MIR616 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR616 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00006DC233_9606 precursor_RNA 97 6

HGNC: 32872,

RefSeq: NR_030346,

Ensembl: ENST00000385293 (view in UCSC) ,

miRBase: MI0003629,

Rfam: RF00995,

ENA: LM609574.1:1..97:precursor_RNA,

URS00005D986D_9606 miRNA 22 5

RefSeq: NR_030346,

LncBase: hsa-miR-616-5p,

miRBase: MIMAT0003284,

TarBase: hsa-miR-616-5p,

ENA: LM379874.1:1..22:ncRNA, LM609574.1:16..37:ncRNA,

URS00005E3F32_9606 miRNA 22 5

RefSeq: NR_030346,

LncBase: hsa-miR-616-3p,

miRBase: MIMAT0004805,

TarBase: hsa-miR-616-3p,

ENA: LM380414.1:1..22:ncRNA, LM609574.1:56..77:ncRNA,

URS0000EFBF25_9606 precursor_RNA 63 1

MirGeneDB: Hsa-Mir-616,

URS0000EFE401_9606 miRNA 24 1

MirGeneDB: Hsa-Mir-616_5p,

MIR616 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR616 Gene

No ASD Table

Relevant External Links for MIR616 Gene

GeneLoc Exon Structure for
MIR616

No data available for mRNA/cDNA for MIR616 Gene

Expression for MIR616 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR616 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR616

genes like me logo Genes that share expression patterns with MIR616: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR616 Gene

Orthologs for MIR616 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR616 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-616 31
  • 98 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
-- 31
  • 36 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 62 (a)
OneToOne
Species where no ortholog for MIR616 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR616 Gene

ENSEMBL:
Gene Tree for MIR616 (if available)
TreeFam:
Gene Tree for MIR616 (if available)

Paralogs for MIR616 Gene

No data available for Paralogs for MIR616 Gene

Variants for MIR616 Gene

Additional dbSNP identifiers (rs#s) for MIR616 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR616 Gene

Variant ID Type Subtype PubMed ID
dgv2651n54 CNV loss 21841781
esv2759901 CNV gain 17122850
nsv428283 CNV gain 18775914
nsv469411 CNV loss 19166990
nsv482992 CNV gain+loss 15286789
nsv559034 CNV loss 21841781
nsv559036 CNV loss 21841781

Additional Variant Information for MIR616 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR616

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR616 Gene

Disorders for MIR616 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR616 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spinal disease
  • spinal disorder
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR616: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR616 Gene

Publications for MIR616 Gene

  1. Computational identification and analysis of early diagnostic biomarkers for kidney cancer. (PMID: 31350524) Tang T … Tan J (Journal of human genetics 2019) 3
  2. Long noncoding RNA TUSC7 inhibits cell proliferation, migration and invasion by regulating SOCS4 (SOCS5) expression through targeting miR-616 in endometrial carcinoma. (PMID: 31200002) Wu X … Wan Q (Life sciences 2019) 3
  3. MicroRNA-616 promotes the progression of ovarian cancer by targeting TIMP2. (PMID: 29658596) Chen Z … Wang J (Oncology reports 2018) 3
  4. MiR-616-3p promotes angiogenesis and EMT in gastric cancer via the PTEN/AKT/mTOR pathway. (PMID: 29777710) Wu ZH … Guo WJ (Biochemical and biophysical research communications 2018) 3
  5. MiR-616-3p modulates cell proliferation and migration through targeting tissue factor pathway inhibitor 2 in preeclampsia. (PMID: 30028057) Xu Y … Sun L (Cell proliferation 2018) 3

Products for MIR616 Gene

Sources for MIR616 Gene