microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR615 Gene

Subcategory (RNA class) for MIR615 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR615 Gene

  • MIMAT0004804 50
  • MIMAT0003283 50
  • MI0003628 50
  • MIRN615 3
  • Mir-615 3
  • RF00879 168

External Ids for MIR615 Gene

Previous HGNC Symbols for MIR615 Gene

  • MIRN615

Previous GeneCards Identifiers for MIR615 Gene

  • GC12U901015
  • GC12P052716
  • GC12P054427

Summaries for MIR615 Gene

Entrez Gene Summary for MIR615 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR615 Gene

MIR615 (MicroRNA 615) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR615 include Mesothelioma, Malignant and Systemic Lupus Erythematosus. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR615 Gene

Additional gene information for MIR615 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR615 Gene

Genomics for MIR615 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR615 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J054037 Enhancer 0.7 Ensembl 600.7 +1.8 1751 0.6 ZNF629 ZIC2 PATZ1 EZH2 ZNF600 ZNF341 ZSCAN29 ZNF639 ZNF524 ZXDB MIR615 HOXC-AS1 piR-30124 HOXC4 HOXC5 FAM242C
GH12J054035 Promoter 0.4 EPDnew 600.7 +1.2 1194 0.1 EZH2 MIR615 HOXC5 piR-30124 ENSG00000273046 HOXC4 FAM242C
GH12J053971 Promoter/Enhancer 2.7 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.2 -30.6 -30638 63 ZNF221 RNF2 CREB1 GATAD2A CTCF ZBTB33 HNRNPL TEAD4 PRDM10 ZNF629 HOTAIR HOXC8 HOXC-AS1 HOXC11 HOXC4 HOXC9 HOXC6 HOXC10 HOXC5 HNRNPA1
GH12J054188 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 11.7 +154.9 154850 2.4 ZNF629 PRDM10 SIX5 IKZF1 JUND GABPA ZNF143 RBFOX2 PKNOX1 POLR2A LOC105369777 SMUG1 lnc-CBX5-2 lnc-HNRNPA1-3 FLJ12825 ENSG00000258344 PCBP2 SP1 HNRNPA1 AAAS
GH12J054130 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 +100.9 100858 8.4 GATAD2A CTCF ZBTB33 FOXA1 PRDM1 ZIC2 ZNF776 ZSCAN4 PATZ1 REST FLJ12825 TARBP2 ENSG00000248576 SMUG1 MIR615 HOXC4 HOXC5 HOXC6 ENSG00000260470 HOXC8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR615 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR615 Gene

Genomic Locations for MIR615 Gene
chr12:54,033,950-54,034,045
(GRCh38/hg38)
Size:
96 bases
Orientation:
Plus strand
chr12:54,427,734-54,427,829
(GRCh37/hg19)
Size:
96 bases
Orientation:
Plus strand

Genomic View for MIR615 Gene

Genes around MIR615 on UCSC Golden Path with GeneCards custom track
MIR615 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR615 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR615 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR615 Gene

Proteins for MIR615 Gene

Post-translational modifications for MIR615 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR615 Gene

Domains & Families for MIR615 Gene

Gene Families for MIR615 Gene

HGNC:
genes like me logo Genes that share domains with MIR615: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR615 Gene

Function for MIR615 Gene

Phenotypes From GWAS Catalog for MIR615 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR615 Gene

Localization for MIR615 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR615 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR615 Gene

Pathways & Interactions for MIR615 Gene

PathCards logo

SuperPathways for MIR615 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR615: view

Pathways by source for MIR615 Gene

1 KEGG pathway for MIR615 Gene

Gene Ontology (GO) - Biological Process for MIR615 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR615: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR615 Gene

Drugs & Compounds for MIR615 Gene

No Compound Related Data Available

Transcripts for MIR615 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR615 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000070789A_9606 precursor_RNA 96 6

HGNC: 32871,

RefSeq: NR_030753,

Ensembl: ENST00000384839 (view in UCSC) ,

miRBase: MI0003628,

Rfam: RF00879,

ENA: LM609573.1:1..96:precursor_RNA,

URS00004D8280_9606 miRNA 22 6

RefSeq: NR_030753,

LncBase: hsa-miR-615-5p,

miRBase: MIMAT0004804,

MirGeneDB: Hsa-Mir-615_5p,

TarBase: hsa-miR-615-5p,

ENA: LM380413.1:1..22:ncRNA, LM609573.1:18..39:ncRNA,

URS00003D5391_9606 miRNA 22 5

RefSeq: NR_030753,

LncBase: hsa-miR-615-3p,

miRBase: MIMAT0003283,

TarBase: hsa-miR-615-3p,

ENA: LM379873.1:1..22:ncRNA, LM609573.1:61..82:ncRNA,

URS0000EFBA76_9606 precursor_RNA 65 1

MirGeneDB: Hsa-Mir-615,

URS000075AA7E_9606 miRNA 21 1

MirGeneDB: Hsa-Mir-615_3p,

MIR615 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR615 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR615 Gene

No ASD Table

Relevant External Links for MIR615 Gene

GeneLoc Exon Structure for
MIR615

Expression for MIR615 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR615 Gene

genes like me logo Genes that share expression patterns with MIR615: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR615 Gene

Orthologs for MIR615 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR615 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-615 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-615 31
  • 99 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir615 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-615 31
  • 96 (a)
OneToOne
Species where no ortholog for MIR615 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR615 Gene

ENSEMBL:
Gene Tree for MIR615 (if available)
TreeFam:
Gene Tree for MIR615 (if available)

Paralogs for MIR615 Gene

No data available for Paralogs for MIR615 Gene

Variants for MIR615 Gene

Additional dbSNP identifiers (rs#s) for MIR615 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR615 Gene

Variant ID Type Subtype PubMed ID
esv2759900 CNV gain+loss 17122850
nsv428282 CNV gain 18775914
nsv558998 CNV loss 21841781
nsv826379 CNV gain 20364138
nsv832418 CNV loss 17160897

Additional Variant Information for MIR615 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR615

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR615 Gene

Disorders for MIR615 Gene

MalaCards: The human disease database

(11) MalaCards diseases for MIR615 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
mesothelioma, malignant
  • mesom
systemic lupus erythematosus
  • sle
corneal dystrophy, congenital stromal
  • cscd
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
pancreatic adenocarcinoma
  • adenocarcinoma of the pancreas
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR615

genes like me logo Genes that share disorders with MIR615: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR615 Gene

Publications for MIR615 Gene

  1. miR-615-5p is restrictedly expressed in cirrhotic and cancerous liver tissues and its overexpression alleviates the tumorigenic effects in hepatocellular carcinoma. (PMID: 22819824) El Tayebi HM … Abdelaziz AI (FEBS letters 2012) 2 3
  2. miR-615-3p promotes the phagocytic capacity of splenic macrophages by targeting ligand-dependent nuclear receptor corepressor in cirrhosis-related portal hypertension. (PMID: 21565892) Jiang A … Yang J (Experimental biology and medicine (Maywood, N.J.) 2011) 2 3
  3. miR-615 Inhibits Prostate Cancer Cell Proliferation and Invasion by Directly Targeting Cyclin D2. (PMID: 29471894) Huang F … Jiang H (Oncology research 2019) 3
  4. MicroRNA-615-5p Regulates Angiogenesis and Tissue Repair by Targeting AKT/eNOS (Protein Kinase B/Endothelial Nitric Oxide Synthase) Signaling in Endothelial Cells. (PMID: 31092013) Icli B … Feinberg MW (Arteriosclerosis, thrombosis, and vascular biology 2019) 3
  5. The novel circular RNA circ-CAMK2A enhances lung adenocarcinoma metastasis by regulating the miR-615-5p/fibronectin 1 pathway. (PMID: 31889960) Du J … Yuan W (Cellular & molecular biology letters 2019) 3

Products for MIR615 Gene

Sources for MIR615 Gene