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Aliases for MIR615 Gene

Subcategory (RNA class) for MIR615 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR615 Gene

  • MicroRNA 615 2 3 5
  • Hsa-Mir-615 3
  • Mir-615 3
  • MIRN615 3

External Ids for MIR615 Gene

ORGUL Members for MIR615 Gene

Previous HGNC Symbols for MIR615 Gene

  • MIRN615

Previous GeneCards Identifiers for MIR615 Gene

  • GC12U901015
  • GC12P052716
  • GC12P054427

Summaries for MIR615 Gene

Entrez Gene Summary for MIR615 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR615 Gene

MIR615 (MicroRNA 615) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR615 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR615 Gene

Genomics for MIR615 Gene

GeneHancer (GH) Regulatory Elements for MIR615 Gene

Promoters and enhancers for MIR615 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I053971 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.2 -43.7 -43707 36.8 FEZF1 DMAP1 IRF4 ZNF213 ZNF416 ZNF143 ZNF548 SP3 NFYC ZNF610 HOXC11 HOXC9 HOXC6 HOXC10 GC12P054010 GC12P054044 MIR196A2 HNRNPA1 ZNF740 ENSG00000258344
GH12I054188 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.7 +154.9 154863 1.6 PKNOX1 ARNT ARID4B SIN3A ETS1 ZNF766 GLIS2 ZNF213 E2F8 ELK1 SMUG1 LOC105369777 FLJ12825 HOXC8 HOXC-AS1 HOXC-AS2 HOXC9 HOXC6 ENSG00000257605 MIR615
GH12I054195 Enhancer 1.3 FANTOM5 Ensembl ENCODE 11.8 +162.7 162726 3.1 HDGF PKNOX1 KLF17 ZNF335 ZNF121 GLIS2 ZNF366 SMARCC2 KLF7 FOS HOXC8 HOXC-AS1 HOXC-AS2 HOXC9 HOXC6 MIR196A2 MIR615 HOXC4 HOXC5 LOC102724030
GH12I054079 Promoter/Enhancer 1.4 Ensembl ENCODE 10.7 +47.3 47339 4.6 HDGF PKNOX1 FEZF1 GLI4 ZNF2 ZNF121 GLIS2 ZNF213 KLF7 REST LOC100240735 LOC100240734 SMUG1 FLJ12825 CBX5 MIR615 HOXC4 HOXC5 HOXC6 HOXC8
GH12I054191 Enhancer 1.1 Ensembl ENCODE 11.7 +157.8 157788 0.9 ATF1 ARID4B SIN3A ZNF2 IRF4 ZNF143 KLF7 ATF7 KLF13 DEK HOXC8 HOXC-AS1 HOXC-AS2 HOXC9 HOXC6 MIR615 HOXC4 HOXC5 MAP3K12 LOC102724030
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR615 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR615 Gene

Genomic Locations for MIR615 Gene
chr12:54,033,950-54,034,045
(GRCh38/hg38)
Size:
96 bases
Orientation:
Plus strand
chr12:54,427,734-54,427,829
(GRCh37/hg19)

Genomic View for MIR615 Gene

Genes around MIR615 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR615 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR615 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR615 Gene

Proteins for MIR615 Gene

Post-translational modifications for MIR615 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR615 Gene

Domains & Families for MIR615 Gene

Gene Families for MIR615 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR615: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR615 Gene

Function for MIR615 Gene

Phenotypes From GWAS Catalog for MIR615 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR615 Gene

Localization for MIR615 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR615 Gene

Pathways & Interactions for MIR615 Gene

SuperPathways for MIR615 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR615: view

Pathways by source for MIR615 Gene

1 KEGG pathway for MIR615 Gene

Interacting Proteins for MIR615 Gene

Gene Ontology (GO) - Biological Process for MIR615 Gene

None

No data available for SIGNOR curated interactions for MIR615 Gene

Drugs & Compounds for MIR615 Gene

No Compound Related Data Available

Transcripts for MIR615 Gene

mRNA/cDNA for MIR615 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR615 Gene

No ASD Table

Relevant External Links for MIR615 Gene

GeneLoc Exon Structure for
MIR615
ECgene alternative splicing isoforms for
MIR615

Expression for MIR615 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR615 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR615 Gene:

MIR615
genes like me logo Genes that share expression patterns with MIR615: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR615 Gene

Orthologs for MIR615 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR615 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-615 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-615 34
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir615 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-615 34
  • 96 (a)
OneToOne
Species where no ortholog for MIR615 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR615 Gene

ENSEMBL:
Gene Tree for MIR615 (if available)
TreeFam:
Gene Tree for MIR615 (if available)

Paralogs for MIR615 Gene

No data available for Paralogs for MIR615 Gene

Variants for MIR615 Gene

Sequence variations from dbSNP and Humsavar for MIR615 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000396997 -- 54,033,853(+) G/C upstream_transcript_variant
rs1000873736 -- 54,034,219(+) C/T downstream_transcript_variant
rs1001439680 -- 54,034,180(+) C/T downstream_transcript_variant
rs1001521503 -- 54,033,461(+) G/A upstream_transcript_variant
rs1002445805 -- 54,032,701(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR615 Gene

Variant ID Type Subtype PubMed ID
esv2759900 CNV gain+loss 17122850
nsv428282 CNV gain 18775914
nsv558998 CNV loss 21841781
nsv826379 CNV gain 20364138
nsv832418 CNV loss 17160897

Additional Variant Information for MIR615 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR615

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR615 Gene

Disorders for MIR615 Gene

Additional Disease Information for MIR615

No disorders were found for MIR615 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR615 Gene

Publications for MIR615 Gene

  1. KDM4B-mediated epigenetic silencing of miRNA-615-5p augments RAB24 to facilitate malignancy of hepatoma cells. (PMID: 27487123) Chen Z … Tang H (Oncotarget 2017) 3 58
  2. MiR-615-3p inhibits the osteogenic differentiation of human lumbar ligamentum flavum cells via suppression of osteogenic regulators GDF5 and FOXO1. (PMID: 28460412) Yin J … Cao Y (Cell biology international 2017) 3 58
  3. CDX2 inhibits pancreatic adenocarcinoma cell proliferation via promoting tumor suppressor miR-615-5p. (PMID: 26269116) Jiang Y … Zhang J (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 58
  4. miR-615-5p prevents proliferation and migration through negatively regulating serine hydromethyltransferase 2 (SHMT2) in hepatocellular carcinoma. (PMID: 26662310) Wu X … Liang G (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 58
  5. miR-615-5p is epigenetically inactivated and functions as a tumor suppressor in pancreatic ductal adenocarcinoma. (PMID: 24769899) Gao W … Miao Y (Oncogene 2015) 3 58

Products for MIR615 Gene

Sources for MIR615 Gene

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