microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR614 Gene

Subcategory (RNA class) for MIR614 Gene

miRNA

Quality Score for this RNA gene is

15

Aliases for MIR614 Gene

  • MicroRNA 614 2 3 5
  • Hsa-MiR-614 168 179
  • MIMAT0003282 53
  • Hsa-Mir-614 3
  • MI0003627 53
  • MIRN614 3
  • MIR614 2

External Ids for MIR614 Gene

Previous HGNC Symbols for MIR614 Gene

  • MIRN614

Previous GeneCards Identifiers for MIR614 Gene

  • GC12P012961
  • GC12P013068
  • GC12P012918
  • GC12P012922
  • GC12P012921
  • GC12P012891
  • GC12P012916

Summaries for MIR614 Gene

Entrez Gene Summary for MIR614 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR614 Gene

MIR614 (MicroRNA 614) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR614 include Lymphoma, Hodgkin, Classic and Duodenum Adenocarcinoma. Among its related pathways are GPCRs, Class C Metabotropic glutamate, pheromone.

Additional gene information for MIR614 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR614 Gene

Genomics for MIR614 Gene

GeneHancer (GH) Regulatory Elements for MIR614 Gene

Promoters and enhancers for MIR614 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J012915 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 750.6 +0.6 631 2.8 CTCF POLR2A USF2 MIXL1 MYC CC2D1A L3MBTL2 MAX RAD21 ELF3 MIR614 lnc-DDX47-3 GPRC5D-AS1 lnc-GPRC5A-2 GPRC5A
GH12J013193 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.9 +287.3 287263 19.5 SIN3A CTCF POLR2A ZNF362 MYC HLF MAX RAD21 NFIB ZNF384 EMP1 HTR7P1 MIR614 GSG1 GPRC5D-AS1 ENSG00000255621 HEBP1 ENSG00000221611 ENSG00000256011 GPRC5D
GH12J013043 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10.2 +128.7 128672 3.4 CTCF SIX5 ZBTB6 RBPJ HCFC1 ZNF133 POLR2A GTF2F1 ZNF384 SP7 FAM234B RF00001-074 DDX47 HTR7P1 ENSG00000255621 HEBP1 EMP1 MIR614 PTMAP9 RPL13AP20
GH12J012869 Promoter/Enhancer 1.4 EPDnew ENCODE dbSUPER 11.1 -43.3 -43290 5.9 SIN3A GATA3 SREBF1 POLR2A TCF7L2 ZNF217 HLF MNT ZBTB33 ZNF384 lnc-GPRC5A-4 GPRC5A MIR614 RPL13AP20
GH12J013221 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +307.2 307198 3.7 TCF7L2 SREBF1 MNT ZBTB33 MAFK CEBPG KLF14 CREB1 CEBPA CTBP1 DDX47 MIR614 ENSG00000256011 GSG1 HEBP1 HSALNG0089444 piR-50357-033
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR614 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR614 Gene

Genomic Locations for MIR614 Gene
chr12:12,915,829-12,915,918
(GRCh38/hg38)
Size:
90 bases
Orientation:
Plus strand
chr12:13,068,763-13,068,852
(GRCh37/hg19)
Size:
90 bases
Orientation:
Plus strand

Genomic View for MIR614 Gene

Genes around MIR614 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR614 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR614 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR614 Gene

Proteins for MIR614 Gene

Post-translational modifications for MIR614 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR614 Gene

Domains & Families for MIR614 Gene

Gene Families for MIR614 Gene

HGNC:
genes like me logo Genes that share domains with MIR614: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR614 Gene

Function for MIR614 Gene

Phenotypes From GWAS Catalog for MIR614 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR614 Gene

Localization for MIR614 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR614 Gene

Pathways & Interactions for MIR614 Gene

PathCards logo

SuperPathways for MIR614 Gene

genes like me logo Genes that share pathways with MIR614: view

Pathways by source for MIR614 Gene

1 BioSystems pathway for MIR614 Gene

Gene Ontology (GO) - Biological Process for MIR614 Gene

None

No data available for SIGNOR curated interactions for MIR614 Gene

Drugs & Compounds for MIR614 Gene

No Compound Related Data Available

Transcripts for MIR614 Gene

mRNA/cDNA for MIR614 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNACentral transcripts :
(1) LncBase transcripts :
(2) miRBase transcripts :
(1) TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR614 Gene

No ASD Table

Relevant External Links for MIR614 Gene

GeneLoc Exon Structure for
MIR614
ECgene alternative splicing isoforms for
MIR614

Expression for MIR614 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR614 Gene

mRNA differential expression in normal tissues according to GTEx for MIR614 Gene

This gene is overexpressed in Lung (x12.5).

NURSA nuclear receptor signaling pathways regulating expression of MIR614 Gene:

MIR614
genes like me logo Genes that share expression patterns with MIR614: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR614 Gene

Orthologs for MIR614 Gene

Evolution for MIR614 Gene

ENSEMBL:
Gene Tree for MIR614 (if available)
TreeFam:
Gene Tree for MIR614 (if available)

No data available for Orthologs for MIR614 Gene

Paralogs for MIR614 Gene

No data available for Paralogs for MIR614 Gene

Variants for MIR614 Gene

Sequence variations from dbSNP and Humsavar for MIR614 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1002034384 -- 12,915,407(+) G/A upstream_transcript_variant
rs1002067326 -- 12,915,773(+) C/T upstream_transcript_variant
rs1005538346 -- 12,914,702(+) G/A/T upstream_transcript_variant
rs1005777285 -- 12,914,866(+) C/T upstream_transcript_variant
rs1005915684 -- 12,916,062(+) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR614 Gene

Variant ID Type Subtype PubMed ID
esv2745567 CNV deletion 23290073
esv3628627 CNV gain 21293372
nsv1159986 CNV deletion 26073780
nsv832333 CNV gain 17160897

Additional Variant Information for MIR614 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR614

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR614 Gene

Disorders for MIR614 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR614 Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
lymphoma, hodgkin, classic
  • chl
duodenum adenocarcinoma
  • duodenal adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR614

genes like me logo Genes that share disorders with MIR614: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR614 Gene

Publications for MIR614 Gene

  1. Upregulation of miR-614 promotes proliferation and inhibits apoptosis in ovarian cancer by suppressing PPP2R2A expression. (PMID: 29532877) Zhang J … Zhang H (Molecular medicine reports 2018) 3 56
  2. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 56
  3. [MiR-614 inhibited lung cancer cell invasion and proliferation via targeting PSA]. (PMID: 25342037) Lv F … Xue Q (Zhongguo fei ai za zhi = Chinese journal of lung cancer 2014) 3 56
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 56
  5. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 56

Products for MIR614 Gene

Sources for MIR614 Gene