microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6127 Gene

Subcategory (RNA class) for MIR6127 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR6127 Gene

  • MicroRNA 6127 2 3 5
  • Hsa-Mir-6127 2 3
  • MIR6127 2 5
  • MicroRNA Mir-6127 3
  • MIMAT0024610 50
  • MI0021271 50

External Ids for MIR6127 Gene

Previous GeneCards Identifiers for MIR6127 Gene

  • GC01U904100

Summaries for MIR6127 Gene

Entrez Gene Summary for MIR6127 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6127 Gene

MIR6127 (MicroRNA 6127) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR6127 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6127 Gene

Genomics for MIR6127 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR6127 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J022629 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.7 +2.9 2895 3.1 KDM1A FOXA1 RFX1 MNT BCOR GATA3 ADNP ZMYM3 TCF7L2 SMARCA5 MIR6127 C1QA EPHA8
GH01J022610 Enhancer 0.8 dbSUPER 0.4 +18.4 18434 9.4 REST TFE3 KDM1A MTA2 ZNF24 ZNF600 ZNF341 CBX3 ZNF766 CTBP1 MIR6127 C1QA EPHA8
GH01J022636 Promoter 0.4 EPDnew 0.7 -3.2 -3243 0.1 ZIC2 C1QA MN308914 MIR6127 EPHA8
GH01J022625 Enhancer 0.6 Ensembl dbSUPER 0.4 +6.8 6781 0.8 ESR1 USF1 NRF1 USF2 LUZP1 MIR6127 C1QA EPHA8
GH01J022563 Promoter 1.1 EPDnew Ensembl 0.2 +69.9 69865 0.6 ZIC2 ZSCAN4 EZH2 KLF9 ZBTB48 ZBTB26 ZNF423 ZFHX2 ZNF777 ZNF335 EPHA8 MIR6127 C1QA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6127 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR6127 Gene

Genomic Locations for MIR6127 Gene
chr1:22,633,258-22,633,366
(GRCh38/hg38)
Size:
109 bases
Orientation:
Minus strand

Genomic View for MIR6127 Gene

Genes around MIR6127 on UCSC Golden Path with GeneCards custom track
MIR6127 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR6127 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6127 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6127 Gene

Proteins for MIR6127 Gene

Post-translational modifications for MIR6127 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6127 Gene

Domains & Families for MIR6127 Gene

Gene Families for MIR6127 Gene

HGNC:
genes like me logo Genes that share domains with MIR6127: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6127 Gene

Function for MIR6127 Gene

Phenotypes From GWAS Catalog for MIR6127 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6127 Gene

Localization for MIR6127 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6127 Gene

Pathways & Interactions for MIR6127 Gene

PathCards logo

SuperPathways for MIR6127 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR6127 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR6127 Gene

Drugs & Compounds for MIR6127 Gene

No Compound Related Data Available

Transcripts for MIR6127 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR6127 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075F071_9606 precursor_RNA 109 4

HGNC: 50163,

RefSeq: NR_106742,

Ensembl: ENST00000614019 (view in UCSC) ,

miRBase: MI0021271,

URS000075F03F_9606 miRNA 19 2

RefSeq: NR_106742,

miRBase: MIMAT0024610,

MIR6127 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6127 Gene

No ASD Table

Relevant External Links for MIR6127 Gene

GeneLoc Exon Structure for
MIR6127

No data available for mRNA/cDNA for MIR6127 Gene

Expression for MIR6127 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6127 Gene

Orthologs for MIR6127 Gene

Evolution for MIR6127 Gene

ENSEMBL:
Gene Tree for MIR6127 (if available)
TreeFam:
Gene Tree for MIR6127 (if available)

No data available for Orthologs for MIR6127 Gene

Paralogs for MIR6127 Gene

No data available for Paralogs for MIR6127 Gene

Variants for MIR6127 Gene

Additional dbSNP identifiers (rs#s) for MIR6127 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR6127 Gene

Variant ID Type Subtype PubMed ID
esv34161 CNV loss 18971310

Additional Variant Information for MIR6127 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6127

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR6127 Gene

Disorders for MIR6127 Gene

Additional Disease Information for MIR6127

No disorders were found for MIR6127 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6127 Gene

Publications for MIR6127 Gene

  1. Transcription factors are targeted by differentially expressed miRNAs in primates. (PMID: 22454130) Dannemann M … Kelso J (Genome biology and evolution 2012) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR6127 Gene

Sources for MIR6127 Gene