microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6126 Gene

Subcategory (RNA class) for MIR6126 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR6126 Gene

  • MicroRNA 6126 2 3 5
  • Hsa-Mir-6126 2 3
  • MIR6126 2 5
  • MicroRNA Mir-6126 3
  • MIMAT0024599 50
  • MI0021260 50

External Ids for MIR6126 Gene

Previous GeneCards Identifiers for MIR6126 Gene

  • GC16U901756

Summaries for MIR6126 Gene

Entrez Gene Summary for MIR6126 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6126 Gene

MIR6126 (MicroRNA 6126) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR6126 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6126 Gene

Genomics for MIR6126 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR6126 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J003481 Enhancer 0.7 ENCODE 0.7 +4.0 3956 0.6 JUND ZIC2 RXRB PATZ1 USF1 ZFHX2 RCOR1 DNMT3B KLF17 FOSL2 ENSG00000262370 NAA60 RF00017-1935 MIR6126 C16orf90 ENSG00000263212
GH16J003491 Enhancer 0.6 Ensembl 0.4 -6.0 -6022 1.4 REST TCF12 ZNF341 CTBP1 NFIC ZFHX2 SAP130 POLR2A RAD21 NFIB NAA60 RPL18P12 C16orf90 MIR6126 ENSG00000263212
GH16J003478 Enhancer 0.3 Ensembl 0.4 +6.9 6903 0.7 ZNF341 KLF1 RF00017-1935 NAA60 MIR6126 C16orf90 ENSG00000263212 ENSG00000285329
GH16J003492 Enhancer 0.2 Ensembl 0.4 -8.1 -8132 0.8 C16orf90 RPL18P12 MIR6126 ENSG00000263212 NAA60
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6126 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR6126 Gene

Genomic Locations for MIR6126 Gene
chr16:3,485,381-3,485,469
(GRCh38/hg38)
Size:
89 bases
Orientation:
Minus strand

Genomic View for MIR6126 Gene

Genes around MIR6126 on UCSC Golden Path with GeneCards custom track
MIR6126 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR6126 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6126 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6126 Gene

Proteins for MIR6126 Gene

Post-translational modifications for MIR6126 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6126 Gene

Domains & Families for MIR6126 Gene

Gene Families for MIR6126 Gene

HGNC:
genes like me logo Genes that share domains with MIR6126: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6126 Gene

Function for MIR6126 Gene

Phenotypes From GWAS Catalog for MIR6126 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6126 Gene

Localization for MIR6126 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6126 Gene

Pathways & Interactions for MIR6126 Gene

PathCards logo

SuperPathways for MIR6126 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR6126 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR6126 Gene

Drugs & Compounds for MIR6126 Gene

No Compound Related Data Available

Transcripts for MIR6126 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR6126 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075DE21_9606 precursor_RNA 89 4

HGNC: 50099,

RefSeq: NR_106741,

Ensembl: ENST00000622849 (view in UCSC) ,

miRBase: MI0021260,

URS000075D118_9606 miRNA 18 2

RefSeq: NR_106741,

miRBase: MIMAT0024599,

MIR6126 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6126 Gene

No ASD Table

Relevant External Links for MIR6126 Gene

GeneLoc Exon Structure for
MIR6126

No data available for mRNA/cDNA for MIR6126 Gene

Expression for MIR6126 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6126 Gene

Orthologs for MIR6126 Gene

Evolution for MIR6126 Gene

ENSEMBL:
Gene Tree for MIR6126 (if available)
TreeFam:
Gene Tree for MIR6126 (if available)

No data available for Orthologs for MIR6126 Gene

Paralogs for MIR6126 Gene

No data available for Paralogs for MIR6126 Gene

Variants for MIR6126 Gene

Additional dbSNP identifiers (rs#s) for MIR6126 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR6126 Gene

Variant ID Type Subtype PubMed ID
nsv952908 CNV deletion 24416366

Additional Variant Information for MIR6126 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6126

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR6126 Gene

Disorders for MIR6126 Gene

Additional Disease Information for MIR6126

No disorders were found for MIR6126 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6126 Gene

Publications for MIR6126 Gene

  1. Serum miRNAs Predicting Sustained HBs Antigen Reduction 48 Weeks after Pegylated Interferon Therapy in HBe Antigen-Negative Patients. (PMID: 30004437) Fujita K … Masaki T (International journal of molecular sciences 2018) 3
  2. Ubiquitous Release of Exosomal Tumor Suppressor miR-6126 from Ovarian Cancer Cells. (PMID: 27742688) Kanlikilicer P … Lopez-Berestein G (Cancer research 2016) 3
  3. Induction of the cellular microRNA, Hs_154, by West Nile virus contributes to virus-mediated apoptosis through repression of antiapoptotic factors. (PMID: 22345437) Smith JL … Hirsch AJ (Journal of virology 2012) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR6126 Gene

Sources for MIR6126 Gene