microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6125 Gene

Data sources for MIR6125 Gene:

RNA type for MIR6125 Gene

miRNA

Aliases for MIR6125 Gene

External Ids for MIR6125 Gene

Previous GeneCards Identifiers for MIR6125 Gene

  • GC12U901936

Summaries for MIR6125 Gene

Entrez Gene Summary for MIR6125 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6125 Gene

MIR6125 (MicroRNA 6125) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Signaling by GPCR and Deubiquitination.

Additional gene information for MIR6125 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6125 Gene

Genomics for MIR6125 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR6125 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J062256 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +0.9 885 9.5 BCLAF1 SP1 ZNF207 NCOR1 IKZF1 MYC SIX5 JUND ZNF580 ZNF592 USP15 TAFA2 HSALNG0091839 MIR6125 MON2 MIRLET7IHG LINC01465 lnc-FAM19A2-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6125 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR6125 Gene

Latest Assembly
chr12:62,260,359-62,260,454
(GRCh38/hg38)
Size:
96 bases
Orientation:
Plus strand

Previous Assembly
chr12:62,654,140-62,654,235
(GRCh37/hg19 by Entrez Gene)
Size:
96 bases
Orientation:
Plus strand

Genomic View for MIR6125 Gene

Genes around MIR6125 on UCSC Golden Path with GeneCards custom track
MIR6125 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR6125 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6125 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6125 Gene

Proteins for MIR6125 Gene

Post-translational modifications for MIR6125 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6125 Gene

Domains & Families for MIR6125 Gene

Gene Families for MIR6125 Gene

HGNC:
genes like me logo Genes that share domains with MIR6125: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6125 Gene

Function for MIR6125 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6125 Gene

Localization for MIR6125 Gene

Gene Ontology (GO) - Cellular Components for MIR6125 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 31926946
genes like me logo Genes that share ontologies with MIR6125: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR6125 Gene

Pathways & Interactions for MIR6125 Gene

genes like me logo Genes that share pathways with MIR6125: view

Pathways by source for MIR6125 Gene

Gene Ontology (GO) - Biological Process for MIR6125 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR6125 Gene

Drugs & Compounds for MIR6125 Gene

No Compound Related Data Available

Transcripts for MIR6125 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR6125 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000075E538_9606 precursor_RNA 96 4

RefSeq: NR_106740,

Ensembl: ENST00000618986 (view in UCSC) ,

miRBase: MI0021259,

ENA: LM611678.1:1..96:precursor_RNA,

URS000075F0F0_9606 miRNA 20 3

RefSeq: NR_106740,

miRBase: MIMAT0024598,

ENA: LM383108.1:1..20:ncRNA, LM611678.1:60..79:ncRNA,

MIR6125 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR6125 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6125 Gene

No ASD Table

Relevant External Links for MIR6125 Gene

GeneLoc Exon Structure for
MIR6125

Expression for MIR6125 Gene

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6125 Gene

Orthologs for MIR6125 Gene

Evolution for MIR6125 Gene

ENSEMBL:
Gene Tree for MIR6125 (if available)
TreeFam:
Gene Tree for MIR6125 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR6125

No data available for Orthologs for MIR6125 Gene

Paralogs for MIR6125 Gene

No data available for Paralogs for MIR6125 Gene

Variants for MIR6125 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR6125 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR6125 Gene

Variant ID Type Subtype PubMed ID
nsv952195 CNV duplication 24416366

Additional Variant Information for MIR6125 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6125
Leiden Open Variation Database (LOVD)
MIR6125

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR6125 Gene

Disorders for MIR6125 Gene

Additional Disease Information for MIR6125

No disorders were found for MIR6125 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6125 Gene

Publications for MIR6125 Gene

  1. Exosomal miR-146a-5p from Treponema pallidum-stimulated macrophages reduces endothelial cells permeability and monocyte transendothelial migration by targeting JAM-C. (PMID: 31926946) Hu W … Zhang R (Experimental cell research 2020) 3
  2. Induction of the cellular microRNA, Hs_154, by West Nile virus contributes to virus-mediated apoptosis through repression of antiapoptotic factors. (PMID: 22345437) Smith JL … Hirsch AJ (Journal of virology 2012) 3
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR6125 Gene

Sources for MIR6125 Gene