microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR612 Gene

Data sources for MIR612 Gene:

Subcategory (RNA class) for MIR612 Gene

miRNA

Aliases for MIR612 Gene

External Ids for MIR612 Gene

Previous HGNC Symbols for MIR612 Gene

  • MIRN612

Previous GeneCards Identifiers for MIR612 Gene

  • GC11P064969
  • GC11P065211
  • GC11P065448
  • GC11P065459
  • GC11P065551
  • GC11P065558
  • GC11P065580
  • GC11P065619
  • GC11P065473
  • GC11P065481
  • GC11P065492
  • GC11P065507
  • GC11P065515
  • GC11P065524
  • GC11P065534
  • GC11P065541
  • GC11P065788

Summaries for MIR612 Gene

Entrez Gene Summary for MIR612 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR612 Gene

MIR612 (MicroRNA 612) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR612 include Systemic Lupus Erythematosus and Chromosome 5Q Deletion Syndrome.

Rfam classification for MIR612 Gene

Additional gene information for MIR612 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR612 Gene

Genomics for MIR612 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR612 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR612 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR612 Gene

Latest Assembly
chr11:65,444,458-65,444,557
(GRCh38/hg38)
Size:
100 bases
Orientation:
Plus strand

Previous Assembly
chr11:65,211,929-65,212,028
(GRCh37/hg19 by Entrez Gene)
Size:
100 bases
Orientation:
Plus strand

Genomic View for MIR612 Gene

Genes around MIR612 on UCSC Golden Path with GeneCards custom track
MIR612 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR612 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR612 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR612 Gene

Proteins for MIR612 Gene

Post-translational modifications for MIR612 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR612 Gene

Domains & Families for MIR612 Gene

Gene Families for MIR612 Gene

HGNC:
genes like me logo Genes that share domains with MIR612: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR612 Gene

Function for MIR612 Gene

Phenotypes From GWAS Catalog for MIR612 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR612 Gene

Localization for MIR612 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR612 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR612 Gene

Pathways & Interactions for MIR612 Gene

PathCards logo

SuperPathways for MIR612 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR612 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR612: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR612 Gene

Drugs & Compounds for MIR612 Gene

No Compound Related Data Available

Transcripts for MIR612 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR612 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00006E8395_9606 pre_miRNA 100 4

RefSeq: NR_030343,

Ensembl: ENST00000384994 (view in UCSC) ,

miRBase: MI0003625,

Rfam: RF00959,

URS0000759916_9606 miRNA 25 4

RefSeq: NR_030343,

LncBase: hsa-miR-612,

miRBase: MIMAT0003280,

TarBase: hsa-miR-612,

URS0001BC1DF2_9606 pre_miRNA 100 1

Rfam: RF00959,

MIR612 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR612 Gene

No ASD Table

Relevant External Links for MIR612 Gene

GeneLoc Exon Structure for
MIR612

No data available for mRNA/cDNA for MIR612 Gene

Expression for MIR612 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR612 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR612

genes like me logo Genes that share expression patterns with MIR612: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR612 Gene

Orthologs for MIR612 Gene

Evolution for MIR612 Gene

ENSEMBL:
Gene Tree for MIR612 (if available)
TreeFam:
Gene Tree for MIR612 (if available)

No data available for Orthologs for MIR612 Gene

Paralogs for MIR612 Gene

No data available for Paralogs for MIR612 Gene

Variants for MIR612 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR612 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR612 Gene

Variant ID Type Subtype PubMed ID
esv2422285 CNV deletion 17116639
nsv526181 CNV gain 19592680

Additional Variant Information for MIR612 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR612

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR612 Gene

Disorders for MIR612 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR612 Gene - From: MID and COP

Disorder Aliases PubMed IDs
systemic lupus erythematosus
  • sle
chromosome 5q deletion syndrome
  • 5q- syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR612

genes like me logo Genes that share disorders with MIR612: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR612 Gene

Publications for MIR612 Gene

  1. MiR-612 regulates invadopodia of hepatocellular carcinoma by HADHA-mediated lipid reprogramming. (PMID: 32033570) Liu Y … Wu WZ (Journal of hematology & oncology 2020) 3
  2. Downregulated long noncoding RNA LUCAT1 inhibited proliferation and promoted apoptosis of cardiomyocyte via miR-612/HOXA13 pathway in chronic heart failure. (PMID: 31957853) Li T … Lei Z (European review for medical and pharmacological sciences 2020) 3
  3. LncRNA LINC01061 sponges miR-612 to regulate the oncogenic role of SEMA4D in cholangiocarcinoma. (PMID: 30967271) Yu A … Zhang X (Biochemical and biophysical research communications 2019) 3
  4. NFKB1-miR-612-FAIM2 pathway regulates tumorigenesis in neurofibromatosis type 1. (PMID: 31197610) Wang M … Liu Z (In vitro cellular & developmental biology. Animal 2019) 3
  5. Implication of miR-612 and miR-1976 in the regulation of TP53 and CD40 and their relationship in the response to specific weight-loss diets. (PMID: 30089130) Garcia-Lacarte M … Milagro FI (PloS one 2018) 3

Products for MIR612 Gene

Sources for MIR612 Gene