microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6086 Gene

Data sources for MIR6086 Gene:

Subcategory (RNA class) for MIR6086 Gene

miRNA

Aliases for MIR6086 Gene

External Ids for MIR6086 Gene

Previous GeneCards Identifiers for MIR6086 Gene

  • GC0XU901953

Summaries for MIR6086 Gene

Entrez Gene Summary for MIR6086 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6086 Gene

MIR6086 (MicroRNA 6086) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR6086 include Anal Fistula and Hemorrhoid.

Additional gene information for MIR6086 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6086 Gene

Genomics for MIR6086 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR6086 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ013591 Enhancer 0.3 Ensembl 250.7 +0.9 909 0.8 ARNT EP300 MIR6086 lnc-TCEANC-2 EGFL6 TCEANC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6086 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR6086 Gene

Latest Assembly
chrX:13,590,292-13,590,346
(GRCh38/hg38)
Size:
55 bases
Orientation:
Plus strand

Previous Assembly
chrX:13,608,411-13,608,465
(GRCh37/hg19 by Entrez Gene)
Size:
55 bases
Orientation:
Plus strand

Genomic View for MIR6086 Gene

Genes around MIR6086 on UCSC Golden Path with GeneCards custom track
MIR6086 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR6086 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6086 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6086 Gene

Proteins for MIR6086 Gene

Post-translational modifications for MIR6086 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6086 Gene

Domains & Families for MIR6086 Gene

Gene Families for MIR6086 Gene

HGNC:
genes like me logo Genes that share domains with MIR6086: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6086 Gene

Function for MIR6086 Gene

Gene Ontology (GO) - Molecular Function for MIR6086 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 22142236
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22142236
genes like me logo Genes that share ontologies with MIR6086: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6086 Gene

Localization for MIR6086 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6086 Gene

Pathways & Interactions for MIR6086 Gene

PathCards logo

SuperPathways for MIR6086 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR6086 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035278 miRNA mediated inhibition of translation IDA 22142236
genes like me logo Genes that share ontologies with MIR6086: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR6086 Gene

Drugs & Compounds for MIR6086 Gene

No Compound Related Data Available

Transcripts for MIR6086 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR6086 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075EA84_9606 precursor_RNA 55 3

RefSeq: NR_106734,

Ensembl: ENST00000638065 (view in UCSC) ,

miRBase: MI0020363,

URS000075EDA9_9606 miRNA 20 2

RefSeq: NR_106734,

miRBase: MIMAT0023711,

MIR6086 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6086 Gene

No ASD Table

Relevant External Links for MIR6086 Gene

GeneLoc Exon Structure for
MIR6086

No data available for mRNA/cDNA for MIR6086 Gene

Expression for MIR6086 Gene

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6086 Gene

Orthologs for MIR6086 Gene

Evolution for MIR6086 Gene

ENSEMBL:
Gene Tree for MIR6086 (if available)
TreeFam:
Gene Tree for MIR6086 (if available)

No data available for Orthologs for MIR6086 Gene

Paralogs for MIR6086 Gene

No data available for Paralogs for MIR6086 Gene

Variants for MIR6086 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR6086 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR6086 Gene

Variant ID Type Subtype PubMed ID
esv3576773 CNV gain 25503493

Additional Variant Information for MIR6086 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6086

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR6086 Gene

Disorders for MIR6086 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR6086 Gene - From: COP

Disorder Aliases PubMed IDs
anal fistula
  • rectal fistula
hemorrhoid
  • hemorrhoidal disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR6086

genes like me logo Genes that share disorders with MIR6086: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR6086 Gene

Publications for MIR6086 Gene

  1. Inhibition of hsa-miR-6086 protects human umbilical vein endothelial cells against TNFα-induced proliferation inhibition and apoptosis via CDH5. (PMID: 29605606) Cai X … Huang Z (Gene 2018) 3
  2. Discovery and characterization of novel microRNAs during endothelial differentiation of human embryonic stem cells. (PMID: 22142236) Yoo JK … Kim JK (Stem cells and development 2012) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR6086 Gene

Sources for MIR6086 Gene