microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6073 Gene

Data sources for MIR6073 Gene:

RNA type for MIR6073 Gene

miRNA

Aliases for MIR6073 Gene

External Ids for MIR6073 Gene

Previous GeneCards Identifiers for MIR6073 Gene

  • GC11U902152

Summaries for MIR6073 Gene

Entrez Gene Summary for MIR6073 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6073 Gene

MIR6073 (MicroRNA 6073) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Signaling by GPCR and Endochondral Ossification.

Additional gene information for MIR6073 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6073 Gene

Genomics for MIR6073 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR6073 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J015965 Promoter/Enhancer 2.1 UCNEbase FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +1.3 1308 6.4 NCOR1 IKZF1 JUND ZNF592 ATF2 NFIC BCL11A SMAD5 BHLHE40 TBP MIR6073 lnc-PLEKHA7-8 ENSG00000254878 C11orf58 SOX6 INSC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6073 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR6073 Gene

Latest Assembly
chr11:15,969,533-15,969,621
(GRCh38/hg38)
Size:
89 bases
Orientation:
Minus strand

Previous Assembly
chr11:15,991,079-15,991,167
(GRCh37/hg19 by Entrez Gene)
Size:
89 bases
Orientation:
Minus strand

Genomic View for MIR6073 Gene

Genes around MIR6073 on UCSC Golden Path with GeneCards custom track
MIR6073 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR6073 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6073 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6073 Gene

Proteins for MIR6073 Gene

Post-translational modifications for MIR6073 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6073 Gene

Domains & Families for MIR6073 Gene

Gene Families for MIR6073 Gene

HGNC:
genes like me logo Genes that share domains with MIR6073: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6073 Gene

Function for MIR6073 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR6073 Gene

Localization for MIR6073 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6073 Gene

Pathways & Interactions for MIR6073 Gene

genes like me logo Genes that share pathways with MIR6073: view

Gene Ontology (GO) - Biological Process for MIR6073 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR6073 Gene

Drugs & Compounds for MIR6073 Gene

No Compound Related Data Available

Transcripts for MIR6073 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR6073 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000075BE97_9606 precursor_RNA 89 3

RefSeq: NR_106721,

Ensembl: ENST00000352083 (view in UCSC) ,

miRBase: MI0020350,

URS000075A441_9606 miRNA 20 2

RefSeq: NR_106721,

miRBase: MIMAT0023698,

MIR6073 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6073 Gene

No ASD Table

Relevant External Links for MIR6073 Gene

GeneLoc Exon Structure for
MIR6073

No data available for mRNA/cDNA for MIR6073 Gene

Expression for MIR6073 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6073 Gene

Orthologs for MIR6073 Gene

Evolution for MIR6073 Gene

ENSEMBL:
Gene Tree for MIR6073 (if available)
TreeFam:
Gene Tree for MIR6073 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR6073

No data available for Orthologs for MIR6073 Gene

Paralogs for MIR6073 Gene

No data available for Paralogs for MIR6073 Gene

Variants for MIR6073 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR6073 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR6073 Gene

Variant ID Type Subtype PubMed ID
nsv832074 CNV loss 17160897

Additional Variant Information for MIR6073 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6073
Leiden Open Variation Database (LOVD)
MIR6073

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR6073 Gene

Disorders for MIR6073 Gene

Additional Disease Information for MIR6073

No disorders were found for MIR6073 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6073 Gene

Publications for MIR6073 Gene

  1. Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs. (PMID: 22282338) Voellenkle C … Martelli F (RNA (New York, N.Y.) 2012) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR6073 Gene

Sources for MIR6073 Gene