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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR6073 (MicroRNA 6073) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Signaling by GPCR and Signaling by Wnt.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J015965 | Promoter/Enhancer | 2.1 | UCNEbase FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 600.7 | +1.3 | 1308 | 6.4 | ZNF629 ZNF512 RFX1 LEF1 IKZF1 BACH1 JUND PRDM1 ZNF24 TCF12 | MIR6073 lnc-PLEKHA7-8 ENSG00000254878 C11orf58 SOX6 LOC102724957 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by Wnt |
.71
|
|
2 | Deactivation of the beta-catenin transactivating complex | ||
3 | Signaling by GPCR | ||
4 | Endochondral Ossification | ||
5 | NOTCH1 regulation of human endothelial cell calcification |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075BE97_9606 | precursor_RNA | 89 | 4 |
HGNC: 50128, RefSeq: NR_106721, Ensembl: ENST00000352083 (view in UCSC) , miRBase: MI0020350, |
URS000075A441_9606 | miRNA | 20 | 2 |
RefSeq: NR_106721, miRBase: MIMAT0023698, |
No disorders were found for MIR6073 Gene.