microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR6070 Gene

Subcategory (RNA class) for MIR6070 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR6070 Gene

  • MicroRNA 6070 2 3 5
  • Hsa-Mir-6070 2 3
  • MIR6070 2 5
  • MicroRNA Mir-6070 3
  • MIMAT0023695 50
  • MI0020347 50

External Ids for MIR6070 Gene

Previous GeneCards Identifiers for MIR6070 Gene

  • GC21U900572

Summaries for MIR6070 Gene

Entrez Gene Summary for MIR6070 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6070 Gene

MIR6070 (MicroRNA 6070) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR6070 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR6070 Gene

Genomics for MIR6070 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR6070 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J043595 Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 +4.9 4879 20.2 ARHGAP35 HNRNPL CREB1 GATAD2A CTCF ZBTB33 YBX1 ZNF629 PRDM10 TFE3 RRP1B ENSG00000184441 WDR4 PWP2 HSF2BP U2AF1 ENSG00000233754 CFAP410 SIK1 PDXK
GH21J043585 Enhancer 1.3 ENCODE CraniofacialAtlas dbSUPER 0.4 +23.4 23405 3.1 CREB1 GATAD2A TEAD4 TFE3 SOX13 RCOR2 FOXA1 PRDM1 RXRB IRF2 PDXK FRGCA piR-60246-100 H2BS1 MIR6070 HSF2BP
GH21J043588 Enhancer 1.1 ENCODE dbSUPER 0.4 +19.5 19548 4 GATAD2A ATF7 TFE3 SOX13 RCOR2 JUND FOXA1 PKNOX1 RXRB IRF2 HSF2BP PDXK SIK1 FRGCA RRP1B piR-60246-100 MIR6070 H2BS1
GH21J043618 Enhancer 0.8 Ensembl ENCODE 0.4 -9.3 -9322 1.8 CTCF REST SCRT2 CBX3 TRIM28 ZC3H8 KLF8 RAD21 ZNF610 SKIL HSF2BP RRP1B PDXK SIK1 FRGCA MIR6070 RF00017-3724 H2BS1
GH21J043578 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.3 +30.6 30616 1.7 FOXA1 CTBP1 CUX1 GATA3 DPF2 JUND HLF SMARCE1 piR-60246-100 HSF2BP PDXK FRGCA AGPAT3 SIK1 H2BS1 MIR6070
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR6070 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR6070 Gene

Genomic Locations for MIR6070 Gene
chr21:43,609,887-43,609,989
(GRCh38/hg38)
Size:
103 bases
Orientation:
Minus strand

Genomic View for MIR6070 Gene

Genes around MIR6070 on UCSC Golden Path with GeneCards custom track
MIR6070 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR6070 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6070 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6070 Gene

Proteins for MIR6070 Gene

Post-translational modifications for MIR6070 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6070 Gene

Domains & Families for MIR6070 Gene

Gene Families for MIR6070 Gene

HGNC:
genes like me logo Genes that share domains with MIR6070: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR6070 Gene

Function for MIR6070 Gene

Phenotypes From GWAS Catalog for MIR6070 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6070 Gene

Localization for MIR6070 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR6070 Gene

Pathways & Interactions for MIR6070 Gene

PathCards logo

SuperPathways for MIR6070 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR6070 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR6070 Gene

Drugs & Compounds for MIR6070 Gene

No Compound Related Data Available

Transcripts for MIR6070 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR6070 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075A145_9606 precursor_RNA 103 4

HGNC: 49950,

RefSeq: NR_106718,

Ensembl: ENST00000613967 (view in UCSC) ,

miRBase: MI0020347,

URS000075EFDD_9606 miRNA 19 2

RefSeq: NR_106718,

miRBase: MIMAT0023695,

MIR6070 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6070 Gene

No ASD Table

Relevant External Links for MIR6070 Gene

GeneLoc Exon Structure for
MIR6070

No data available for mRNA/cDNA for MIR6070 Gene

Expression for MIR6070 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6070 Gene

Orthologs for MIR6070 Gene

Evolution for MIR6070 Gene

ENSEMBL:
Gene Tree for MIR6070 (if available)
TreeFam:
Gene Tree for MIR6070 (if available)

No data available for Orthologs for MIR6070 Gene

Paralogs for MIR6070 Gene

No data available for Paralogs for MIR6070 Gene

Variants for MIR6070 Gene

Additional dbSNP identifiers (rs#s) for MIR6070 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR6070 Gene

Variant ID Type Subtype PubMed ID
nsv1061539 CNV loss 25217958
nsv1065359 CNV gain 25217958
nsv459289 CNV loss 19166990
nsv470903 CNV loss 18288195
nsv521700 CNV loss 19592680
nsv587690 CNV loss 21841781
nsv587700 CNV loss 21841781
nsv834106 CNV loss 17160897

Additional Variant Information for MIR6070 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6070

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR6070 Gene

Disorders for MIR6070 Gene

Additional Disease Information for MIR6070

No disorders were found for MIR6070 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6070 Gene

Publications for MIR6070 Gene

  1. Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs. (PMID: 22282338) Voellenkle C … Martelli F (RNA (New York, N.Y.) 2012) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR6070 Gene

Sources for MIR6070 Gene