microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR607 Gene

Data sources for MIR607 Gene:

Subcategory (RNA class) for MIR607 Gene

miRNA

Aliases for MIR607 Gene

External Ids for MIR607 Gene

Previous HGNC Symbols for MIR607 Gene

  • MIRN607

Previous GeneCards Identifiers for MIR607 Gene

  • GC10M098579

Summaries for MIR607 Gene

Entrez Gene Summary for MIR607 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR607 Gene

MIR607 (MicroRNA 607) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR607 Gene

Additional gene information for MIR607 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR607 Gene

Genomics for MIR607 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR607 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J096586 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 +242.1 242100 5.3 ZBTB10 MXD4 NR2C1 DEK SMAD5 ETS1 POLR2A BHLHE40 ELF1 THAP11 LOC105378443 TM9SF3 lnc-LCOR-4 lnc-PIK3AP1-1 NPM1P26 MIR607 LCOR HSALNG0079886 piR-34822-047 TLL2
GH10J096579 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 10.6 +247.8 247767 2.7 ZBTB10 FEZF1 IKZF1 ZEB1 ZIC2 ZNF610 ZNF513 ZNF623 ZNF639 KLF7 piR-34822-047 ZNF518A MMS19 TCTN3 CCNJ LCOR NPM1P26 EXOSC1 TM9SF3 MIR607
GH10J096699 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 11.5 +126.9 126869 5.4 BCL11A POLR2A IRF4 TRIM22 EBF1 MAX TAF1 SPI1 BHLHE40 BATF RNU6-1274P MIR607 LCOR RF00017-758 piR-36245-001 PIK3AP1 MN309109 TM9SF3
GH10J096640 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.9 +187.6 187573 0.8 MNT ZNF217 POLR2A CTCF BHLHE40 MCM3 REST TRIM22 RXRA SMC3 TCTN3 ZNF518A CCNJ LCOR EXOSC1 NPM1P26 PIK3AP1 MIR607 MMS19 TM9SF3
GH10J096863 Enhancer 1.1 Ensembl ENCODE 12.3 -36.1 -36118 3.4 MXD4 CEBPA ZNF217 FOXA1 HOMEZ KDM6A ZNF610 THAP11 CUX1 NFATC3 LCOR MIR607 FRAT1 RF00017-759 HSALNG0079910 lnc-FRAT1-7 SLIT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR607 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR607 Gene

Latest Assembly
chr10:96,828,669-96,828,764
(GRCh38/hg38)
Size:
96 bases
Orientation:
Minus strand

Previous Assembly
chr10:98,588,426-98,588,521
(GRCh37/hg19 by Entrez Gene)
Size:
96 bases
Orientation:
Minus strand

chr10:98,588,426-98,588,521
(GRCh37/hg19 by Ensembl)
Size:
96 bases
Orientation:
Minus strand

Genomic View for MIR607 Gene

Genes around MIR607 on UCSC Golden Path with GeneCards custom track
MIR607 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR607 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR607 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR607 Gene

Proteins for MIR607 Gene

Post-translational modifications for MIR607 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR607 Gene

Domains & Families for MIR607 Gene

Gene Families for MIR607 Gene

HGNC:
genes like me logo Genes that share domains with MIR607: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR607 Gene

Function for MIR607 Gene

Phenotypes From GWAS Catalog for MIR607 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR607 Gene

Localization for MIR607 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR607 gene
Compartment Confidence
plasma membrane 1
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR607 Gene

Pathways & Interactions for MIR607 Gene

PathCards logo

SuperPathways for MIR607 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR607 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR607: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR607 Gene

Drugs & Compounds for MIR607 Gene

No Compound Related Data Available

Transcripts for MIR607 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR607 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000722917_9606 pre_miRNA 96 4

RefSeq: NR_030338,

Ensembl: ENST00000385241 (view in UCSC) ,

miRBase: MI0003620,

Rfam: RF00974,

URS0000759A61_9606 miRNA 21 4

RefSeq: NR_030338,

LncBase: hsa-miR-607,

miRBase: MIMAT0003275,

TarBase: hsa-miR-607,

URS0001BC1EDD_9606 pre_miRNA 96 1

Rfam: RF00974,

URS0001BC409D_9606 pre_miRNA 96 1

Rfam: RF00974,

MIR607 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR607 Gene

No ASD Table

Relevant External Links for MIR607 Gene

GeneLoc Exon Structure for
MIR607

No data available for mRNA/cDNA for MIR607 Gene

Expression for MIR607 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR607

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR607 Gene

Orthologs for MIR607 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR607 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 99 (a)
OneToOne
Species where no ortholog for MIR607 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR607 Gene

ENSEMBL:
Gene Tree for MIR607 (if available)
TreeFam:
Gene Tree for MIR607 (if available)

Paralogs for MIR607 Gene

No data available for Paralogs for MIR607 Gene

Variants for MIR607 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR607 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR607 Gene

Variant ID Type Subtype PubMed ID
esv3577638 CNV gain 25503493
nsv1053801 CNV gain 25217958
nsv1110852 OTHER inversion 24896259
nsv825532 CNV gain 20364138

Additional Variant Information for MIR607 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR607

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR607 Gene

Disorders for MIR607 Gene

Additional Disease Information for MIR607

No disorders were found for MIR607 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR607 Gene

Publications for MIR607 Gene

  1. LINC01559 accelerates pancreatic cancer cell proliferation and migration through YAP-mediated pathway. (PMID: 31608998) Lou C … Zhang Y (Journal of cellular physiology 2020) 3
  2. Long non‑coding RNA TP73 antisense RNA 1 facilitates the proliferation and migration of cervical cancer cells via regulating microRNA‑607/cyclin D2. (PMID: 31432138) Zhang H … Fan T (Molecular medicine reports 2019) 3
  3. Circular RNA circ-CBFB promotes proliferation and inhibits apoptosis in chronic lymphocytic leukemia through regulating miR-607/FZD3/Wnt/β-catenin pathway. (PMID: 29902450) Xia L … Xia R (Biochemical and biophysical research communications 2018) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3
  5. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 3

Products for MIR607 Gene

Sources for MIR607 Gene