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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR6068 (MicroRNA 6068) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01J063327 | Enhancer | 0.8 | ENCODE | 250.7 | -0.8 | -801 | 0.3 | CTCF BHLHE40 SIN3A REST MAX TRIM22 ZNF341 RAD21 RFX5 YY1 | HSALNG0004111 MIR6068 ENSG00000236674 ALG6 FOXD3 | |
GH01J063319 | Promoter/Enhancer | 1.8 | EPDnew FANTOM5 Ensembl ENCODE | 0.7 | +3.5 | 3465 | 7.8 | ZBTB10 FEZF1 MNT ETS1 BHLHE40 ZIC2 ZNF610 ZNF623 REST FOXA2 | FOXD3 FOXD3-AS1 NONHSAG001697.2 lnc-FOXD3-4 ENSG00000236674 ALG6 HSALNG0004108 MIR6068 | |
GH01J063329 | Enhancer | 0.3 | Ensembl | 0.7 | -2.5 | -2517 | 0.2 | EZH2 | HSALNG0004111 ENSG00000236674 ALG6 MIR6068 FOXD3 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075CF78_9606 | pre_miRNA | 60 | 3 |
RefSeq: NR_106716, Ensembl: ENST00000615405 (view in UCSC) , miRBase: MI0020345, |
URS000075E142_9606 | miRNA | 21 | 2 |
RefSeq: NR_106716, miRBase: MIMAT0023693, |
No disorders were found for MIR6068 Gene.