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Aliases for MIR605 Gene

Subcategory (RNA class) for MIR605 Gene


Quality Score for this RNA gene is


Aliases for MIR605 Gene

  • MicroRNA 605 2 3 5
  • Hsa-Mir-605 3
  • Mir-605 3
  • MIRN605 3

External Ids for MIR605 Gene

ORGUL Members for MIR605 Gene

Previous HGNC Symbols for MIR605 Gene

  • MIRN605

Previous GeneCards Identifiers for MIR605 Gene

  • GC10P052730
  • GC10P053059

Summaries for MIR605 Gene

Entrez Gene Summary for MIR605 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR605 Gene

MIR605 (MicroRNA 605) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR605 include Ovarian Cancer and Li-Fraumeni Syndrome.

Additional gene information for MIR605 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR605 Gene

Genomics for MIR605 Gene

GeneHancer (GH) Regulatory Elements for MIR605 Gene

Promoters and enhancers for MIR605 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J051300 Enhancer 0.7 Ensembl ENCODE 600.7 +1.6 1577 2.3 SCRT2 ATF2 NR2F2 PRDM4 ENSG00000235279 GC10P051300 GC10P051301 MIR605 ENSG00000231132 PRKG1
GH10J051322 Enhancer 0.5 ENCODE 11.7 +22.7 22663 0.2 PRDM1 CEBPG CEBPA CEBPB YY2 MIR605 ENSG00000231132 RSU1P3 GC10P051555 PRKG1
GH10J051365 Enhancer 0.3 Ensembl 10.5 +65.6 65628 0.4 ZNF513 MIR605 ENSG00000231132 RSU1P3 GC10P051555 PRKG1
GH10J051323 Enhancer 0.2 Ensembl 11.7 +22.9 22928 0.2 MIR605 ENSG00000231132 RSU1P3 GC10P051555 PRKG1
GH10J051257 Enhancer 0.2 Ensembl 10.9 -41.6 -41573 1.6 MIR605 LOC102724719 GC10P051268 ENSG00000231132 PRKG1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR605 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR605 Gene

Genomic Locations for MIR605 Gene
83 bases
Plus strand
83 bases
Plus strand

Genomic View for MIR605 Gene

Genes around MIR605 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR605 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR605 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR605 Gene

Proteins for MIR605 Gene

Post-translational modifications for MIR605 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR605 Gene

Domains & Families for MIR605 Gene

Gene Families for MIR605 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR605: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR605 Gene

Function for MIR605 Gene

Phenotypes From GWAS Catalog for MIR605 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR605 Gene

Localization for MIR605 Gene

Gene Ontology (GO) - Cellular Components for MIR605 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035068 micro-ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with MIR605: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR605 Gene

Pathways & Interactions for MIR605 Gene

PathCards logo

SuperPathways for MIR605 Gene

No Data Available

Interacting Proteins for MIR605 Gene

Gene Ontology (GO) - Biological Process for MIR605 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR605: view

No data available for Pathways by source and SIGNOR curated interactions for MIR605 Gene

Drugs & Compounds for MIR605 Gene

No Compound Related Data Available

Transcripts for MIR605 Gene

mRNA/cDNA for MIR605 Gene

(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNA Central transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR605 Gene

No ASD Table

Relevant External Links for MIR605 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR605 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR605 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR605 Gene:

genes like me logo Genes that share expression patterns with MIR605: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR605 Gene

Orthologs for MIR605 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR605 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-605 35
  • 98 (a)
Species where no ortholog for MIR605 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR605 Gene

Gene Tree for MIR605 (if available)
Gene Tree for MIR605 (if available)

Paralogs for MIR605 Gene

No data available for Paralogs for MIR605 Gene

Variants for MIR605 Gene

Sequence variations from dbSNP and Humsavar for MIR605 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1001737386 -- 51,299,687(+) T/C downstream_transcript_variant
rs1001760782 -- 51,298,026(+) C/T upstream_transcript_variant
rs1006323749 -- 51,297,684(+) T/C upstream_transcript_variant
rs1007541785 -- 51,298,216(+) A/T upstream_transcript_variant
rs1007950700 -- 51,298,689(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR605 Gene

Variant ID Type Subtype PubMed ID
nsv1036645 CNV gain 25217958
nsv831874 CNV gain 17160897

Additional Variant Information for MIR605 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR605 Gene

Disorders for MIR605 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR605 Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • ovarian cancer, somatic
li-fraumeni syndrome
  • lfs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR605

genes like me logo Genes that share disorders with MIR605: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR605 Gene

Publications for MIR605 Gene

  1. Lack of Association between miR-605 rs2043556 Polymorphism and Overall Cancer Risk: A Meta-analysis of Case-control Studies. (PMID: 30514199) Moazeni-Roodi A … Hashemi M (MicroRNA (Shariqah, United Arab Emirates) 2019) 3 58
  2. MicroRNA-605 functions as a tumor suppressor by targeting INPP4B in melanoma. (PMID: 28656250) Chen L … Cao Y (Oncology reports 2017) 3 58
  3. Down-regulation of miR-605 promotes the proliferation and invasion of prostate cancer cells by up-regulating EN2. (PMID: 28943214) Zhou YJ … He XZ (Life sciences 2017) 3 58
  4. Association of microRNA polymorphisms with the risk of head and neck squamous cell carcinoma in a Chinese population: a case-control study. (PMID: 27515039) Miao L … Ma H (Chinese journal of cancer 2016) 3 58
  5. A functional variant in miR-605 modifies the age of onset in Li-Fraumeni syndrome. (PMID: 25683625) Id Said B … Malkin D (Cancer genetics 2015) 3 58

Products for MIR605 Gene

Sources for MIR605 Gene

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