microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR605 Gene

Subcategory (RNA class) for MIR605 Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR605 Gene

  • MicroRNA 605 2 3 5
  • Hsa-Mir-605 2 3
  • MIR605 2 5
  • Hsa-MiR-605-5p 173
  • Hsa-Mir-605-V2 178
  • Hsa-Mir-605-V1 178
  • MIMAT0003273 50
  • MIMAT0026621 50
  • MI0003618 50
  • MIRN605 3
  • Mir-605 3
  • RF01011 168

External Ids for MIR605 Gene

Previous HGNC Symbols for MIR605 Gene

  • MIRN605

Previous GeneCards Identifiers for MIR605 Gene

  • GC10P052730
  • GC10P053059

Summaries for MIR605 Gene

Entrez Gene Summary for MIR605 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR605 Gene

MIR605 (MicroRNA 605) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR605 include Ovarian Cancer and Li-Fraumeni Syndrome.

Rfam classification for MIR605 Gene

Additional gene information for MIR605 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR605 Gene

Genomics for MIR605 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR605 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J051300 Enhancer 0.8 Ensembl ENCODE CraniofacialAtlas 600.7 +1.8 1829 2.8 SCRT2 JUND CEBPB ATF2 NR2F2 PRDM4 GATA2 ENSG00000235279 MIR605 ENSG00000231132 PRKG1 CSTF2T
GH10J051299 Enhancer 0.3 Ensembl 600.7 +0.0 29 0.4 JUND MIR605 ENSG00000235279 PRKG1 CSTF2T
GH10J051297 Enhancer 0.2 Ensembl 600.7 -1.7 -1672 0.2 MIR605 piR-39858-060 PRKG1 CSTF2T
GH10J051322 Enhancer 0.5 ENCODE 11.7 +22.7 22664 0.2 CEBPG PRDM1 CEBPA CEBPB YY2 GATA2 MIR605 ENSG00000231132 RSU1P3 lnc-ASAH2B-6 piR-56759-047 PRKG1 CSTF2T
GH10J051257 Enhancer 0.2 Ensembl 10.9 -41.9 -41871 1 MIR605 LOC102724719 ENSG00000231132 piR-44110-007 PRKG1 CSTF2T
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR605 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR605 Gene

Genomic Locations for MIR605 Gene
chr10:51,299,572-51,299,655
(GRCh38/hg38)
Size:
84 bases
Orientation:
Plus strand
chr10:53,059,333-53,059,415
(GRCh37/hg19)
Size:
83 bases
Orientation:
Plus strand

Genomic View for MIR605 Gene

Genes around MIR605 on UCSC Golden Path with GeneCards custom track
MIR605 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR605 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR605 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR605 Gene

Proteins for MIR605 Gene

Post-translational modifications for MIR605 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR605 Gene

Domains & Families for MIR605 Gene

Gene Families for MIR605 Gene

HGNC:
genes like me logo Genes that share domains with MIR605: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR605 Gene

Function for MIR605 Gene

Phenotypes From GWAS Catalog for MIR605 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR605 Gene

Localization for MIR605 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR605 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR605 Gene

Pathways & Interactions for MIR605 Gene

PathCards logo

SuperPathways for MIR605 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR605 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR605: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR605 Gene

Drugs & Compounds for MIR605 Gene

No Compound Related Data Available

Transcripts for MIR605 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR605 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075ABF4_9606 precursor_RNA 83 5

HGNC: 32861,

RefSeq: NR_030336,

Ensembl: ENST00000385078 (view in UCSC) ,

miRBase: MI0003618,

ENA: LM609572.1:1..83:precursor_RNA,

URS000075CCFA_9606 miRNA 23 4

RefSeq: NR_030336,

miRBase: MIMAT0003273,

TarBase: hsa-miR-605-5p,

ENA: LM609572.1:16..38:ncRNA,

URS0000785093_9606 miRNA 22 4

RefSeq: NR_030336,

miRBase: MIMAT0026621,

MirGeneDB: Hsa-Mir-605-v1_3p,

ENA: LM383182.1:1..22:ncRNA, LM609572.1:51..72:ncRNA,

URS000070DB87_9606 precursor_RNA 84 1

Rfam: RF01011,

URS0000EFC47D_9606 precursor_RNA 60 1

MirGeneDB: Hsa-Mir-605-v2,

MIR605 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR605 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR605 Gene

No ASD Table

Relevant External Links for MIR605 Gene

GeneLoc Exon Structure for
MIR605

Expression for MIR605 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR605 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR605

genes like me logo Genes that share expression patterns with MIR605: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR605 Gene

Orthologs for MIR605 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR605 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-605 31
  • 98 (a)
OneToOne
Species where no ortholog for MIR605 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR605 Gene

ENSEMBL:
Gene Tree for MIR605 (if available)
TreeFam:
Gene Tree for MIR605 (if available)

Paralogs for MIR605 Gene

No data available for Paralogs for MIR605 Gene

Variants for MIR605 Gene

Additional dbSNP identifiers (rs#s) for MIR605 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR605 Gene

Variant ID Type Subtype PubMed ID
nsv1036645 CNV gain 25217958
nsv831874 CNV gain 17160897

Additional Variant Information for MIR605 Gene

Human Gene Mutation Database (HGMD)
MIR605
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR605

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR605 Gene

Disorders for MIR605 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR605 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • ovarian cancer, somatic
li-fraumeni syndrome
  • lfs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR605

genes like me logo Genes that share disorders with MIR605: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR605 Gene

Publications for MIR605 Gene

  1. LncRNA BLACAT1 regulates VASP expression via binding to miR-605-3p and promotes giloma development. (PMID: 31093978) Liu N … Guo Z (Journal of cellular physiology 2019) 3
  2. Lack of Association between miR-605 rs2043556 Polymorphism and Overall Cancer Risk: A Meta-analysis of Case-control Studies. (PMID: 30514199) Moazeni-Roodi A … Hashemi M (MicroRNA (Shariqah, United Arab Emirates) 2019) 3
  3. Circular RNA circ-VANGL1 as a competing endogenous RNA contributes to bladder cancer progression by regulating miR-605-3p/VANGL1 pathway. (PMID: 30146736) Zeng Z … Yu Y (Journal of cellular physiology 2019) 3
  4. Association Between the Polymorphism in miR-605 and Cancer Susceptibility: a PRISMA-Compliant Meta-Analysis. (PMID: 30549993) Hu M … Chen R (Clinical laboratory 2018) 3
  5. Down-regulation of miR-605 promotes the proliferation and invasion of prostate cancer cells by up-regulating EN2. (PMID: 28943214) Zhou YJ … He XZ (Life sciences 2017) 3

Products for MIR605 Gene

Sources for MIR605 Gene