microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR604 Gene

Subcategory (RNA class) for MIR604 Gene

miRNA

Quality Score for this RNA gene is

16

Aliases for MIR604 Gene

  • MicroRNA 604 2 3 5
  • Hsa-MiR-604 168 179
  • MIMAT0003272 53
  • Hsa-Mir-604 3
  • MI0003617 53
  • MIRN604 3
  • RF01041 174
  • MIR604 2

External Ids for MIR604 Gene

Previous HGNC Symbols for MIR604 Gene

  • MIRN604

Previous GeneCards Identifiers for MIR604 Gene

  • GC10M029874
  • GC10M029852

Summaries for MIR604 Gene

Entrez Gene Summary for MIR604 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR604 Gene

MIR604 (MicroRNA 604) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR604 Gene

Additional gene information for MIR604 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR604 Gene

Genomics for MIR604 Gene

GeneHancer (GH) Regulatory Elements for MIR604 Gene

Promoters and enhancers for MIR604 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J029543 Enhancer 0.6 Ensembl dbSUPER 750.6 +1.4 1396 0.2 IKZF2 ELF1 IKZF1 NR2F1 ZNF398 MIR604 lnc-JCAD-11 SVIL
GH10J029542 Enhancer 0.4 Ensembl dbSUPER 750.6 +2.0 1996 0.6 MAFK MIR604 SVIL lnc-JCAD-11
GH10J029628 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 -87.9 -87866 8.8 GATA3 NR2F6 ZNF217 CREB1 MIXL1 ZNF362 ZNF121 MNT NCOA3 CEBPG SVIL RNU6-908P MIR604 lnc-JCAD-8 piR-31534-061 lnc-JCAD-7
GH10J029408 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas 10.3 +135.0 134996 2.6 ZNF785 ZBTB40 POLR2A ZNF362 L3MBTL2 ZFP41 DACH1 ZNF121 MNT ZNF280D SVIL-AS1 ENSG00000287402 LOC105376474 WAC MIR604 MTPAP piR-43458
GH10J029582 Enhancer 1.5 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.1 -41.2 -41195 10.2 CTCF SREBF1 TCF7L2 RAD21 MNT ZNF280D ZNF384 NCOA3 ZSCAN21 ZNF687 SVIL MIR604 CKS1BP2 RNU6-908P SVIL-AS1 ENSG00000212411 MIR938 lnc-JCAD-7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR604 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR604 Gene

Genomic Locations for MIR604 Gene
chr10:29,545,004-29,545,097
(GRCh38/hg38)
Size:
94 bases
Orientation:
Minus strand
chr10:29,833,933-29,834,026
(GRCh37/hg19)
Size:
94 bases
Orientation:
Minus strand

Genomic View for MIR604 Gene

Genes around MIR604 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR604 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR604 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR604 Gene

Proteins for MIR604 Gene

Post-translational modifications for MIR604 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR604 Gene

Domains & Families for MIR604 Gene

Gene Families for MIR604 Gene

HGNC:
genes like me logo Genes that share domains with MIR604: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR604 Gene

Function for MIR604 Gene

Phenotypes From GWAS Catalog for MIR604 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR604 Gene

Localization for MIR604 Gene

Gene Ontology (GO) - Cellular Components for MIR604 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR604: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR604 Gene

Pathways & Interactions for MIR604 Gene

PathCards logo

SuperPathways for MIR604 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR604 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR604: view

No data available for Pathways by source and SIGNOR curated interactions for MIR604 Gene

Drugs & Compounds for MIR604 Gene

No Compound Related Data Available

Transcripts for MIR604 Gene

mRNA/cDNA for MIR604 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNACentral transcripts :
(1) TarBase transcripts :
(2) miRBase transcripts :
(1) LncBase transcripts :
(1) Rfam transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR604 Gene

No ASD Table

Relevant External Links for MIR604 Gene

GeneLoc Exon Structure for
MIR604
ECgene alternative splicing isoforms for
MIR604

Expression for MIR604 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR604 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR604 Gene:

MIR604
genes like me logo Genes that share expression patterns with MIR604: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR604 Gene

Orthologs for MIR604 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR604 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-604 33
  • 97 (a)
OneToOne
Species where no ortholog for MIR604 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR604 Gene

ENSEMBL:
Gene Tree for MIR604 (if available)
TreeFam:
Gene Tree for MIR604 (if available)

Paralogs for MIR604 Gene

No data available for Paralogs for MIR604 Gene

Variants for MIR604 Gene

Sequence variations from dbSNP and Humsavar for MIR604 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000780628 -- 29,546,803(-) A/C upstream_transcript_variant
rs1001944972 -- 29,546,744(-) G/A upstream_transcript_variant
rs1002285213 -- 29,545,872(-) A/G upstream_transcript_variant
rs1002577088 -- 29,544,892(-) T/C/G downstream_transcript_variant
rs1002731038 -- 29,546,693(-) C/G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR604 Gene

Variant ID Type Subtype PubMed ID
nsv1038080 CNV gain 25217958
nsv1129323 OTHER inversion 24896259
nsv831819 CNV loss 17160897

Additional Variant Information for MIR604 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR604

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR604 Gene

Disorders for MIR604 Gene

Additional Disease Information for MIR604

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR604 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR604 Gene

Publications for MIR604 Gene

  1. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J … Wu X (Molecular carcinogenesis 2010) 3 43 56
  2. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J … Wu X (Carcinogenesis 2010) 3 43 56
  3. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y … Wu X (Cancer prevention research (Philadelphia, Pa.) 2008) 3 43 56
  4. Association of polymorphism in microRNA 604 with susceptibility to persistent hepatitis B virus infection and development of hepatocellular carcinoma. (PMID: 25408584) Cheong JY … Kim YJ (Journal of Korean medical science 2014) 3 56
  5. Role of primary miRNA polymorphic variants in metastatic colon cancer patients treated with 5-fluorouracil and irinotecan. (PMID: 20585341) Boni V … Aranda E (The pharmacogenomics journal 2011) 3 56

Products for MIR604 Gene

Sources for MIR604 Gene