microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR602 Gene

Subcategory (RNA class) for MIR602 Gene

miRNA

Number of RNA Genes sources:

3 / 17

Aliases for MIR602 Gene

  • MicroRNA 602 2 3 5
  • Hsa-Mir-602 2 3
  • Hsa-MiR-602 163 173
  • MIR602 2 5
  • MIMAT0003270 50
  • MI0003615 50
  • MIRN602 3

External Ids for MIR602 Gene

Previous HGNC Symbols for MIR602 Gene

  • MIRN602

Previous GeneCards Identifiers for MIR602 Gene

  • GC09P139853
  • GC09P140732

Summaries for MIR602 Gene

Entrez Gene Summary for MIR602 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR602 Gene

MIR602 (MicroRNA 602) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR602 include Systemic Lupus Erythematosus and Deafness, Autosomal Dominant 47. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR602 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR602 Gene

Genomics for MIR602 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR602 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J137845 Enhancer 0.2 Ensembl 0.4 +7.3 7288 1.4 EHMT1 piR-53338-137 MIR602 CACNA1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR602 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR602 Gene

Genomic Locations for MIR602 Gene
chr9:137,838,419-137,838,516
(GRCh38/hg38)
Size:
98 bases
Orientation:
Plus strand
chr9:140,732,871-140,732,968
(GRCh37/hg19)
Size:
98 bases
Orientation:
Plus strand

Genomic View for MIR602 Gene

Genes around MIR602 on UCSC Golden Path with GeneCards custom track
MIR602 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR602 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR602 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR602 Gene

Proteins for MIR602 Gene

Post-translational modifications for MIR602 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR602 Gene

Domains & Families for MIR602 Gene

Gene Families for MIR602 Gene

HGNC:
genes like me logo Genes that share domains with MIR602: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR602 Gene

Function for MIR602 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR602 Gene

Localization for MIR602 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR602 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR602 Gene

Pathways & Interactions for MIR602 Gene

PathCards logo

SuperPathways for MIR602 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR602: view

Pathways by source for MIR602 Gene

1 KEGG pathway for MIR602 Gene

Gene Ontology (GO) - Biological Process for MIR602 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR602 Gene

Drugs & Compounds for MIR602 Gene

No Compound Related Data Available

Transcripts for MIR602 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR602 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075B5BC_9606 precursor_RNA 98 4

HGNC: 32858,

RefSeq: NR_030333,

Ensembl: ENST00000384960 (view in UCSC) ,

miRBase: MI0003615,

URS000075BFCD_9606 miRNA 23 4

RefSeq: NR_030333,

LncBase: hsa-miR-602,

miRBase: MIMAT0003270,

TarBase: hsa-miR-602,

MIR602 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR602 Gene

No ASD Table

Relevant External Links for MIR602 Gene

GeneLoc Exon Structure for
MIR602

No data available for mRNA/cDNA for MIR602 Gene

Expression for MIR602 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR602 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR602

genes like me logo Genes that share expression patterns with MIR602: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR602 Gene

Orthologs for MIR602 Gene

Evolution for MIR602 Gene

ENSEMBL:
Gene Tree for MIR602 (if available)
TreeFam:
Gene Tree for MIR602 (if available)

No data available for Orthologs for MIR602 Gene

Paralogs for MIR602 Gene

No data available for Paralogs for MIR602 Gene

Variants for MIR602 Gene

Additional dbSNP identifiers (rs#s) for MIR602 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR602 Gene

Variant ID Type Subtype PubMed ID
nsv825197 CNV gain 20364138
nsv951213 CNV deletion 24416366

Additional Variant Information for MIR602 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR602

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR602 Gene

Disorders for MIR602 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR602 Gene - From: miR2Disease and DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR602

genes like me logo Genes that share disorders with MIR602: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR602 Gene

Publications for MIR602 Gene

  1. Epigenetically Upregulated MicroRNA-602 Is Involved in a Negative Feedback Loop with FOXK2 in Esophageal Squamous Cell Carcinoma. (PMID: 31401147) Liu M … Sun G (Molecular therapy : the journal of the American Society of Gene Therapy 2019) 3
  2. MicroRNA-602 and microRNA-608 regulate sonic hedgehog expression via target sites in the coding region in human chondrocytes. (PMID: 25385442) Akhtar N … Haqqi TM (Arthritis & rheumatology (Hoboken, N.J.) 2015) 3
  3. MicroRNA-602 regulating tumor suppressive gene RASSF1A is overexpressed in hepatitis B virus-infected liver and hepatocellular carcinoma. (PMID: 20364114) Yang L … Wang G (Cancer biology & therapy 2010) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3
  5. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 3

Products for MIR602 Gene

Sources for MIR602 Gene