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Aliases for MIR597 Gene

Subcategory (RNA class) for MIR597 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR597 Gene

  • MicroRNA 597 2 3 5
  • Hsa-Mir-597 3
  • Mir-597 3
  • MIRN597 3

External Ids for MIR597 Gene

ORGUL Members for MIR597 Gene

Previous HGNC Symbols for MIR597 Gene

  • MIRN597

Previous GeneCards Identifiers for MIR597 Gene

  • GC08P009637

Summaries for MIR597 Gene

Entrez Gene Summary for MIR597 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR597 Gene

MIR597 (MicroRNA 597) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR597 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR597 Gene

Genomics for MIR597 Gene

GeneHancer (GH) Regulatory Elements for MIR597 Gene

Promoters and enhancers for MIR597 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I009781 Enhancer 1 ENCODE 9.8 +40.5 40459 2.1 FOXA2 MLX ARID4B DMAP1 IRF4 ZNF48 YY1 SLC30A9 ATF7 RUNX3 MIR597 ERI1 GC08P009742 PIR58717 TNKS
GH08I009830 Enhancer 0.8 ENCODE 10.1 +89.4 89404 0.2 CTCF LEF1 CEBPG ZSCAN9 RAD21 RFX5 NCOA2 GATA3 SCRT2 SMC3 MIR597 PIR58717 GC08M009858
GH08I009719 Enhancer 0.6 ENCODE 10.8 -21.3 -21319 0.9 SRF ZBTB6 ZIC2 ATF2 RELA POLR2A GLIS1 ZNF143 RUNX3 BCLAF1 MIR597 RPL10P19 TNKS ENSG00000272267 GC08P009743 ENSG00000253697
GH08I009775 Enhancer 0.5 ENCODE 10.6 +34.6 34565 1.1 ATF4 JUND PKNOX1 FOS MIR597 GC08P009742 PIR58717 TNKS
GH08I009829 Enhancer 0.5 ENCODE 10.1 +87.9 87934 0.2 CTCF PKNOX1 ZNF654 TRIM22 SMC3 REST RAD21 MIR597 PIR58717 GC08M009858
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR597 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR597 Gene

Genomic Locations for MIR597 Gene
chr8:9,741,672-9,741,768
(GRCh38/hg38)
Size:
97 bases
Orientation:
Plus strand
chr8:9,599,182-9,599,278
(GRCh37/hg19)

Genomic View for MIR597 Gene

Genes around MIR597 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR597 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR597 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR597 Gene

Proteins for MIR597 Gene

Post-translational modifications for MIR597 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR597 Gene

Domains & Families for MIR597 Gene

Gene Families for MIR597 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR597: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR597 Gene

Function for MIR597 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR597 Gene

Localization for MIR597 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR597 Gene

Pathways & Interactions for MIR597 Gene

SuperPathways for MIR597 Gene

No Data Available

Interacting Proteins for MIR597 Gene

Gene Ontology (GO) - Biological Process for MIR597 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR597 Gene

Drugs & Compounds for MIR597 Gene

No Compound Related Data Available

Transcripts for MIR597 Gene

mRNA/cDNA for MIR597 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR597 Gene

No ASD Table

Relevant External Links for MIR597 Gene

GeneLoc Exon Structure for
MIR597
ECgene alternative splicing isoforms for
MIR597

Expression for MIR597 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR597 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR597 Gene:

MIR597
genes like me logo Genes that share expression patterns with MIR597: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR597 Gene

Orthologs for MIR597 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR597 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-597 34
  • 100 (a)
OneToOne
Species where no ortholog for MIR597 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR597 Gene

ENSEMBL:
Gene Tree for MIR597 (if available)
TreeFam:
Gene Tree for MIR597 (if available)

Paralogs for MIR597 Gene

No data available for Paralogs for MIR597 Gene

Variants for MIR597 Gene

Sequence variations from dbSNP and Humsavar for MIR597 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000278249 -- 9,740,961(+) C/G upstream_transcript_variant
rs1001728573 -- 9,740,082(+) A/C upstream_transcript_variant
rs1002888916 -- 9,740,923(+) C/T upstream_transcript_variant
rs1002921604 -- 9,741,053(+) C/T upstream_transcript_variant
rs1003202158 -- 9,742,120(+) A/G downstream_transcript_variant

Additional Variant Information for MIR597 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR597

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR597 Gene

Disorders for MIR597 Gene

Additional Disease Information for MIR597

No disorders were found for MIR597 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR597 Gene

Publications for MIR597 Gene

  1. miR-597 inhibits breast cancer cell proliferation, migration and invasion through FOSL2. (PMID: 28393251) He J … Pan Q (Oncology reports 2017) 3 58
  2. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini AA … Barker JN (Nature communications 2014) 3 58
  3. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J … Kaessmann H (Genome research 2013) 3 58
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  5. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3 58

Products for MIR597 Gene

Sources for MIR597 Gene

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