Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR595 Gene

Subcategory (RNA class) for MIR595 Gene


Quality Score for this RNA gene is


Aliases for MIR595 Gene

  • MicroRNA 595 2 3 5
  • Hsa-Mir-595 3
  • MIRN595 3

External Ids for MIR595 Gene

Previous HGNC Symbols for MIR595 Gene

  • MIRN595

Previous GeneCards Identifiers for MIR595 Gene

  • GC07M158019
  • GC07M158325

Summaries for MIR595 Gene

Entrez Gene Summary for MIR595 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR595 Gene

MIR595 (MicroRNA 595) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR595 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR595

Additional gene information for MIR595 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR595 Gene

Genomics for MIR595 Gene

GeneHancer (GH) Regulatory Elements for MIR595 Gene

Promoters and enhancers for MIR595 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I158534 Enhancer 0.5 dbSUPER 550.8 -1.9 -1894 0.7 ZFHX2 POLR2A SETDB1 EGR2 MIR595 ENSG00000225365 PTPRN2
GH07I158530 Enhancer 0.5 dbSUPER 550.8 +1.4 1369 2.2 MITF ZNF316 POLR2A BHLHE40 MAX MNT EMSY MIR595 ENSG00000225365 PIR47665 PTPRN2
GH07I158532 Enhancer 0.2 dbSUPER 550.8 -0.1 -61 0.4 MIR595 ENSG00000225365 PTPRN2
GH07I158579 Enhancer 1.1 ENCODE dbSUPER 11.4 -48.8 -48786 3.5 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 SLC30A9 TCF12 MIER2 PPARG ENSG00000225365 MIR595 PIR53228 PTPRN2
GH07I158498 Enhancer 0.8 ENCODE 12 +33.8 33826 0.7 ELF3 FOXA2 MLX ARID4B DMAP1 RARA CREM THAP11 MIXL1 MXD4 MIR595 ENSG00000225365 PTPRN2 LINC01022 PIR47665 GC07P158470
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR595 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR595 Gene

Genomic Locations for MIR595 Gene
96 bases
Minus strand

Genomic View for MIR595 Gene

Genes around MIR595 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR595 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR595 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR595 Gene

ORGUL Member Location for MIR595 Gene

ORGUL Member Location for MIR595 gene

Proteins for MIR595 Gene

Post-translational modifications for MIR595 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR595 Gene

Domains & Families for MIR595 Gene

Gene Families for MIR595 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR595: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR595 Gene

Function for MIR595 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR595 Gene

Localization for MIR595 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR595 Gene

Pathways & Interactions for MIR595 Gene

SuperPathways for MIR595 Gene

No Data Available

Interacting Proteins for MIR595 Gene

Gene Ontology (GO) - Biological Process for MIR595 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR595 Gene

Drugs & Compounds for MIR595 Gene

No Compound Related Data Available

Transcripts for MIR595 Gene

fRNAdb Secondary structures for MIR595 Gene

  • hsa-mir-595_MI0003607_Homo_sapiens_miR-595_stem-loop_hairpin

mRNA/cDNA for MIR595 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR595 Gene

No ASD Table

Relevant External Links for MIR595 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR595 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR595 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR595 Gene:

genes like me logo Genes that share expression patterns with MIR595: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR595 Gene

Orthologs for MIR595 Gene

Evolution for MIR595 Gene

Gene Tree for MIR595 (if available)
Gene Tree for MIR595 (if available)

No data available for Orthologs for MIR595 Gene

Paralogs for MIR595 Gene

No data available for Paralogs for MIR595 Gene

Variants for MIR595 Gene

Sequence variations from dbSNP and Humsavar for MIR595 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1001964647 -- 158,534,040(-) G/T upstream_transcript_variant
rs1002312349 -- 158,533,829(-) A/C upstream_transcript_variant
rs1003138815 -- 158,534,073(-) C/A/T upstream_transcript_variant
rs1003504055 -- 158,534,416(-) T/C upstream_transcript_variant
rs1006083466 -- 158,532,536(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR595 Gene

Variant ID Type Subtype PubMed ID
esv2761162 CNV loss 21179565
esv2764036 CNV gain+loss 21179565
esv3615727 CNV loss 21293372
esv3615729 CNV gain 21293372
esv3615730 CNV loss 21293372
esv3615731 CNV gain 21293372
nsv1020518 CNV gain 25217958
nsv1029709 CNV gain 25217958
nsv609359 CNV loss 21841781

Additional Variant Information for MIR595 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR595 Gene

Disorders for MIR595 Gene

Additional Disease Information for MIR595

No disorders were found for MIR595 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR595 Gene

Publications for MIR595 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 58
  2. MiR-595 targeting regulation of SOX7 expression promoted cell proliferation of human glioblastoma. (PMID: 27133048) Hao Y … Xiao Y (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016) 3 58
  3. Overexpression of miR-595 and miR-1246 in the sera of patients with active forms of inflammatory bowel disease. (PMID: 25628040) Krissansen GW … Fraser AG (Inflammatory bowel diseases 2015) 3 58
  4. Identification of ULK1 as a novel biomarker involved in miR-4487 and miR-595 regulation in neuroblastoma SH-SY5Y cell autophagy. (PMID: 26183158) Chen Y … Liu B (Scientific reports 2015) 3 58
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR595 Gene

Sources for MIR595 Gene

Loading form....