Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR593 Gene

Subcategory (RNA class) for MIR593 Gene


Quality Score for this RNA gene is


Aliases for MIR593 Gene

  • MicroRNA 593 2 3 5
  • Hsa-Mir-593 3
  • MIRN593 3

External Ids for MIR593 Gene

ORGUL Members for MIR593 Gene

Previous HGNC Symbols for MIR593 Gene

  • MIRN593

Previous GeneCards Identifiers for MIR593 Gene

  • GC07P127510
  • GC07P127721

Summaries for MIR593 Gene

Entrez Gene Summary for MIR593 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR593 Gene

MIR593 (MicroRNA 593) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR593 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR593 Gene

Genomics for MIR593 Gene

Genomic Locations for MIR593 Gene

Genomic Locations for MIR593 Gene
100 bases
Plus strand

Genomic View for MIR593 Gene

Genes around MIR593 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR593 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR593 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR593 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR593 Gene

Proteins for MIR593 Gene

Post-translational modifications for MIR593 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR593 Gene

Domains & Families for MIR593 Gene

Gene Families for MIR593 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR593: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR593 Gene

Function for MIR593 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR593 Gene

Localization for MIR593 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR593 Gene

Pathways & Interactions for MIR593 Gene

SuperPathways for MIR593 Gene

No Data Available

Interacting Proteins for MIR593 Gene

Gene Ontology (GO) - Biological Process for MIR593 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR593 Gene

Drugs & Compounds for MIR593 Gene

No Compound Related Data Available

Transcripts for MIR593 Gene

mRNA/cDNA for MIR593 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR593 Gene

No ASD Table

Relevant External Links for MIR593 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR593 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR593 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR593 Gene:

genes like me logo Genes that share expression patterns with MIR593: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR593 Gene

Orthologs for MIR593 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR593 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-593 34
  • 99 (a)
Species where no ortholog for MIR593 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR593 Gene

Gene Tree for MIR593 (if available)
Gene Tree for MIR593 (if available)

Paralogs for MIR593 Gene

No data available for Paralogs for MIR593 Gene

Variants for MIR593 Gene

Sequence variations from dbSNP and Humsavar for MIR593 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000340025 -- 128,081,243(+) G/A upstream_transcript_variant
rs1001816361 -- 128,082,327(+) G/A downstream_transcript_variant
rs1001952863 -- 128,080,009(+) C/T upstream_transcript_variant
rs1001980539 -- 128,080,327(+) G/A upstream_transcript_variant
rs1006125103 -- 128,080,408(+) G/A upstream_transcript_variant

Additional Variant Information for MIR593 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR593 Gene

Disorders for MIR593 Gene

Additional Disease Information for MIR593

No disorders were found for MIR593 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR593 Gene

Publications for MIR593 Gene

  1. MicroRNA-593-3p regulates insulin-promoted glucose consumption by targeting Slc38a1 and CLIP3. (PMID: 27613819) Yang X … Fan H (Journal of molecular endocrinology 2016) 3 58
  2. Mitochondrial fission determines cisplatin sensitivity in tongue squamous cell carcinoma through the BRCA1-miR-593-5p-MFF axis. (PMID: 25912308) Fan S … Li J (Oncotarget 2015) 3 58
  3. Profiling peripheral microRNAs in obesity and type 2 diabetes mellitus. (PMID: 25912229) Wu L … Xi W (APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2015) 3 58
  4. Circulating microRNA profiles and the identification of miR-593 and miR-511 which directly target the PROP1 gene in children with combined pituitary hormone deficiency. (PMID: 25434367) Hu Y … Li G (International journal of molecular medicine 2015) 3 58
  5. Polo-like kinase 1 regulates cell proliferation and is targeted by miR-593* in esophageal cancer. (PMID: 21170987) Ito T … Meltzer SJ (International journal of cancer 2011) 3 58

Products for MIR593 Gene

Sources for MIR593 Gene

Loading form....