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Aliases for MIR592 Gene

Subcategory (RNA class) for MIR592 Gene


Quality Score for this RNA gene is


Aliases for MIR592 Gene

  • MicroRNA 592 2 3 5
  • Hsa-Mir-592 3
  • Mir-592 3
  • MIRN592 3

External Ids for MIR592 Gene

Previous HGNC Symbols for MIR592 Gene

  • MIRN592

Previous GeneCards Identifiers for MIR592 Gene

  • GC07M126486
  • GC07M126698

Summaries for MIR592 Gene

Entrez Gene Summary for MIR592 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR592 Gene

MIR592 (MicroRNA 592) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR592 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR592

Additional gene information for MIR592 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR592 Gene

Genomics for MIR592 Gene

GeneHancer (GH) Regulatory Elements for MIR592 Gene

Promoters and enhancers for MIR592 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I127018 Enhancer 0.3 FANTOM5 0.3 +39.9 39891 0.3 GRM8 ENSG00000230820 MIR592
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR592 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR592 Gene

Genomic Locations for MIR592 Gene
97 bases
Minus strand

Genomic View for MIR592 Gene

Genes around MIR592 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR592 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR592 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR592 Gene

ORGUL Member Location for MIR592 Gene

ORGUL Member Location for MIR592 gene

Proteins for MIR592 Gene

Post-translational modifications for MIR592 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR592 Gene

Domains & Families for MIR592 Gene

Gene Families for MIR592 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR592: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR592 Gene

Function for MIR592 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR592 Gene

Localization for MIR592 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR592 Gene

Pathways & Interactions for MIR592 Gene

SuperPathways for MIR592 Gene

No Data Available

Interacting Proteins for MIR592 Gene

Gene Ontology (GO) - Biological Process for MIR592 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR592 Gene

Drugs & Compounds for MIR592 Gene

No Compound Related Data Available

Transcripts for MIR592 Gene

fRNAdb Secondary structures for MIR592 Gene

  • FR005308

mRNA/cDNA for MIR592 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR592 Gene

No ASD Table

Relevant External Links for MIR592 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR592 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR592 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR592 Gene:

genes like me logo Genes that share expression patterns with MIR592: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR592 Gene

Orthologs for MIR592 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR592 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-592 34
  • 100 (a)
(Pan troglodytes)
Mammalia ptr-mir-592 34
  • 100 (a)
(Canis familiaris)
Mammalia cfa-mir-592 34
  • 96 (a)
(Mus musculus)
Mammalia Mir592 34
  • 96 (a)
Species where no ortholog for MIR592 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR592 Gene

Gene Tree for MIR592 (if available)
Gene Tree for MIR592 (if available)

Paralogs for MIR592 Gene

No data available for Paralogs for MIR592 Gene

Variants for MIR592 Gene

Sequence variations from dbSNP and Humsavar for MIR592 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1001504552 -- 127,059,535(-) C/T upstream_transcript_variant
rs1002299914 -- 127,059,285(-) A/T upstream_transcript_variant
rs1002517148 -- 127,058,068(-) G/A downstream_transcript_variant
rs1004193820 -- 127,058,924(-) C/T upstream_transcript_variant
rs1004269576 -- 127,058,431(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR592 Gene

Variant ID Type Subtype PubMed ID
nsv831121 CNV gain 17160897

Additional Variant Information for MIR592 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR592 Gene

Disorders for MIR592 Gene

Additional Disease Information for MIR592

No disorders were found for MIR592 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR592 Gene

Publications for MIR592 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 58
  2. MiR-592 functions as a tumor suppressor in glioma by targeting IGFBP2. (PMID: 28718372) Peng T … Zuo L (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  3. miR-592 functions as a tumor suppressor in human non-small cell lung cancer by targeting SOX9. (PMID: 28004116) Li Z … Ge L (Oncology reports 2017) 3 58
  4. An oncogenic role of miR-592 in tumorigenesis of human colorectal cancer by targeting Forkhead Box O3A (FoxO3A). (PMID: 27167185) Fu Q … Yang Y (Expert opinion on therapeutic targets 2016) 3 58
  5. Prognostic value of 5-microRNA based signature in T2-T3N0 colon cancer. (PMID: 27485175) Bobowicz M … Jassem J (Clinical & experimental metastasis 2016) 3 58

Products for MIR592 Gene

Sources for MIR592 Gene

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