microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR590 Gene

Subcategory (RNA class) for MIR590 Gene

miRNA

Aliases for MIR590 Gene

External Ids for MIR590 Gene

Previous HGNC Symbols for MIR590 Gene

  • MIRN590

Previous GeneCards Identifiers for MIR590 Gene

  • GC07P073244
  • GC07P073605

Summaries for MIR590 Gene

Entrez Gene Summary for MIR590 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR590 Gene

MIR590 (MicroRNA 590) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR590 include Asymptomatic Dengue and Arteries, Anomalies Of.

Rfam classification for MIR590 Gene

Additional gene information for MIR590 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR590 Gene

Genomics for MIR590 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR590 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR590 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR590 Gene

Latest Assembly
chr7:74,191,198-74,191,294
(GRCh38/hg38)
Size:
97 bases
Orientation:
Plus strand

Previous Assembly
chr7:73,605,528-73,605,624
(GRCh37/hg19 by Entrez Gene)
Size:
97 bases
Orientation:
Plus strand

chr7:73,605,528-73,605,624
(GRCh37/hg19 by Ensembl)
Size:
97 bases
Orientation:
Plus strand

Genomic View for MIR590 Gene

Genes around MIR590 on UCSC Golden Path with GeneCards custom track
MIR590 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR590 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR590 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR590 Gene

Proteins for MIR590 Gene

Post-translational modifications for MIR590 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR590 Gene

Domains & Families for MIR590 Gene

Gene Families for MIR590 Gene

HGNC:
genes like me logo Genes that share domains with MIR590: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR590 Gene

Function for MIR590 Gene

Phenotypes From GWAS Catalog for MIR590 Gene

Gene Ontology (GO) - Molecular Function for MIR590 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 19398468
genes like me logo Genes that share ontologies with MIR590: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR590 Gene

Localization for MIR590 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR590 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR590 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR590: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR590 Gene

Pathways & Interactions for MIR590 Gene

PathCards logo

SuperPathways for MIR590 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR590 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IDA 24288179
GO:0010667 negative regulation of cardiac muscle cell apoptotic process ISS --
GO:0010719 negative regulation of epithelial to mesenchymal transition IDA 26459119
GO:0030335 positive regulation of cell migration IDA 24288179
GO:0032682 negative regulation of chemokine production IDA 25149060
genes like me logo Genes that share ontologies with MIR590: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR590 Gene

Drugs & Compounds for MIR590 Gene

No Compound Related Data Available

Transcripts for MIR590 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR590 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00005CACA0_9606 miRNA 22 6

RefSeq: NR_030321,

LncBase: hsa-miR-590-5p,

miRBase: MIMAT0003258,

MirGeneDB: Hsa-Mir-590_5p,

TarBase: hsa-miR-590-5p,

ENA: LM379870.1:1..22:ncRNA, LM609567.1:16..37:ncRNA,

URS0000272039_9606 miRNA 21 6

RefSeq: NR_030321,

LncBase: hsa-miR-590-3p,

miRBase: MIMAT0004801,

MirGeneDB: Hsa-Mir-590_3p,

TarBase: hsa-miR-590-3p,

ENA: LM380412.1:1..21:ncRNA, LM609567.1:56..76:ncRNA,

URS00004AE041_9606 precursor_RNA 97 5

RefSeq: NR_030321,

Ensembl: ENST00000385008 (view in UCSC) ,

miRBase: MI0003602,

Rfam: RF00928,

ENA: HI397479.1:1..97:misc_RNA, LM609567.1:1..97:precursor_RNA,

URS0000EFF570_9606 precursor_RNA 62 1

MirGeneDB: Hsa-Mir-590,

MIR590 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR590 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR590 Gene

No ASD Table

Relevant External Links for MIR590 Gene

GeneLoc Exon Structure for
MIR590

Expression for MIR590 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR590 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR590

genes like me logo Genes that share expression patterns with MIR590: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR590 Gene

Orthologs for MIR590 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR590 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-590 31
  • 100 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-590 31
  • 69 (a)
OneToOne
Species where no ortholog for MIR590 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR590 Gene

ENSEMBL:
Gene Tree for MIR590 (if available)
TreeFam:
Gene Tree for MIR590 (if available)

Paralogs for MIR590 Gene

No data available for Paralogs for MIR590 Gene

Variants for MIR590 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR590 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR590 Gene

Variant ID Type Subtype PubMed ID
esv3613698 CNV loss 21293372
nsv464563 CNV gain 19166990
nsv607480 CNV gain 21841781
nsv831030 CNV gain 17160897

Additional Variant Information for MIR590 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR590

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR590 Gene

Disorders for MIR590 Gene

MalaCards: The human disease database

(52) MalaCards diseases for MIR590 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
asymptomatic dengue
arteries, anomalies of
  • artery disease
myocarditis
  • myocardial inflammation
extrinsic cardiomyopathy
vulva cancer
  • ca vulva
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR590

genes like me logo Genes that share disorders with MIR590: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR590 Gene

Publications for MIR590 Gene

  1. Long noncoding RNA DUXAP8 regulates proliferation and apoptosis of ovarian cancer cells via targeting miR-590-5p. (PMID: 32749665) Meng Q … Sun X (Human cell 2020) 3
  2. MiR-590 Suppresses Proliferation and Induces Apoptosis in Pancreatic Cancer by Targeting High Mobility Group A2. (PMID: 32588766) Wang YD … Xu MQ (Technology in cancer research & treatment 2020) 3
  3. LncRNA MALAT1 Promotes STAT3-Mediated Endothelial Inflammation by Counteracting the Function of miR-590. (PMID: 33022677) Zhou Q … Wu XL (Cytogenetic and genome research 2020) 3
  4. CFIm25-regulated lncRNA acv3UTR promotes gastric tumorigenesis via miR-590-5p/YAP1 axis. (PMID: 32066878) Liu K … Song X (Oncogene 2020) 3
  5. Circulating microRNA-590-5p functions as a liquid biopsy marker in non-small cell lung cancer. (PMID: 31520555) Khandelwal A … Jain A (Cancer science 2020) 3

Products for MIR590 Gene

Sources for MIR590 Gene