microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR589 Gene

RNA type for MIR589 Gene

miRNA

Aliases for MIR589 Gene

External Ids for MIR589 Gene

Previous HGNC Symbols for MIR589 Gene

  • MIRN589

Previous GeneCards Identifiers for MIR589 Gene

  • GC07M005502
  • GC07M005535

Summaries for MIR589 Gene

Entrez Gene Summary for MIR589 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR589 Gene

MIR589 (MicroRNA 589) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR589 include Brain Glioma. Among its related pathways are miRNA targets in ECM and membrane receptors.

Rfam classification for MIR589 Gene

Additional gene information for MIR589 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR589 Gene

Genomics for MIR589 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR589 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR589 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR589 Gene

Latest Assembly
chr7:5,495,819-5,495,917
(GRCh38/hg38)
Size:
99 bases
Orientation:
Minus strand

Previous Assembly
chr7:5,535,450-5,535,548
(GRCh37/hg19 by Entrez Gene)
Size:
99 bases
Orientation:
Minus strand

chr7:5,535,450-5,535,548
(GRCh37/hg19 by Ensembl)
Size:
99 bases
Orientation:
Minus strand

Genomic View for MIR589 Gene

Genes around MIR589 on UCSC Golden Path with GeneCards custom track
MIR589 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR589 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR589 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR589 Gene

Proteins for MIR589 Gene

Post-translational modifications for MIR589 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR589 Gene

Domains & Families for MIR589 Gene

Gene Families for MIR589 Gene

HGNC:
genes like me logo Genes that share domains with MIR589: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR589 Gene

Function for MIR589 Gene

Phenotypes From GWAS Catalog for MIR589 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR589 Gene

Localization for MIR589 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR589 gene
Compartment Confidence
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MIR589 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR589: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR589 Gene

Pathways & Interactions for MIR589 Gene

PathCards logo

SuperPathways for MIR589 Gene

genes like me logo Genes that share pathways with MIR589: view

Pathways by source for MIR589 Gene

1 BioSystems pathway for MIR589 Gene

Gene Ontology (GO) - Biological Process for MIR589 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR589: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR589 Gene

Drugs & Compounds for MIR589 Gene

No Compound Related Data Available

Transcripts for MIR589 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR589 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00005F9DAE_9606 miRNA 24 6

RefSeq: NR_030318,

LncBase: hsa-miR-589-3p,

miRBase: MIMAT0003256,

MirGeneDB: Hsa-Mir-589_3p,

TarBase: hsa-miR-589-3p,

ENA: LM379868.1:1..24:ncRNA, LM609564.1:61..84:ncRNA,

URS000064C5B0_9606 pre_miRNA 99 5

RefSeq: NR_030318,

Ensembl: ENST00000385238 (view in UCSC) ,

miRBase: MI0003599,

Rfam: RF00987,

ENA: LM609564.1:1..99:precursor_RNA,

URS00004214BB_9606 miRNA 22 5

RefSeq: NR_030318,

LncBase: hsa-miR-589-5p,

miRBase: MIMAT0004799,

TarBase: hsa-miR-589-5p,

ENA: AY940879.1:1..22:ncRNA, LM380410.1:1..22:ncRNA, LM609564.1:24..45:ncRNA,

URS0001BC63B8_9606 pre_miRNA 99 1

Rfam: RF00987,

URS0000EFBC81_9606 pre_miRNA 62 1

MirGeneDB: Hsa-Mir-589,

MIR589 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR589 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR589 Gene

No ASD Table

Relevant External Links for MIR589 Gene

GeneLoc Exon Structure for
MIR589

Expression for MIR589 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR589 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR589

genes like me logo Genes that share expression patterns with MIR589: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR589 Gene

Orthologs for MIR589 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR589 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-589 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-589 30
  • 79 (a)
OneToOne
Species where no ortholog for MIR589 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR589 Gene

ENSEMBL:
Gene Tree for MIR589 (if available)
TreeFam:
Gene Tree for MIR589 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR589

Paralogs for MIR589 Gene

No data available for Paralogs for MIR589 Gene

Variants for MIR589 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR589 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR589 Gene

Variant ID Type Subtype PubMed ID
dgv3482n106 OTHER inversion 24896259
nsv436904 CNV insertion 17901297
nsv471304 CNV loss 18288195
nsv517558 CNV loss 19592680
nsv526194 CNV gain 19592680
nsv830890 CNV loss 17160897

Additional Variant Information for MIR589 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR589
Leiden Open Variation Database (LOVD)
MIR589

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR589 Gene

Disorders for MIR589 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR589 Gene - From: COP

Disorder Aliases PubMed IDs
brain glioma
  • lower grade glioma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR589

genes like me logo Genes that share disorders with MIR589: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR589 Gene

Publications for MIR589 Gene

  1. miRNA589 regulates epithelial-mesenchymal transition in human peritoneal mesothelial cells. (PMID: 23118514) Zhang K … Liu FY (Journal of biomedicine & biotechnology 2012) 2 3
  2. Cyclic RNA hsa_circ_0091017 inhibits proliferation, migration and invasiveness of bladder cancer cells by binding to microRNA-589-5p. (PMID: 31957821) Zhang L … Ren XL (European review for medical and pharmacological sciences 2020) 3
  3. miR‑589‑5p is downregulated in prostate cancer and regulates tumor cell viability and metastasis by targeting CCL‑5. (PMID: 31173214) Ji L … Zhong B (Molecular medicine reports 2019) 3
  4. CircPRKCI-miR-545/589-E2F7 axis dysregulation mediates hydrogen peroxide-induced neuronal cell injury. (PMID: 31053300) Cheng Q … Xu Y (Biochemical and biophysical research communications 2019) 3
  5. Targeting Thyroid Receptor Interacting Protein 6 by MicroRNA-589-5p Inhibits Cell Proliferation, Migration, and Invasion in Endometrial Carcinoma. (PMID: 31424277) Wang Y … Liu Y (Cancer biotherapy & radiopharmaceuticals 2019) 3

Products for MIR589 Gene

Sources for MIR589 Gene