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Aliases for MIR589 Gene

Subcategory (RNA class) for MIR589 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR589 Gene

  • MicroRNA 589 2 3 5
  • Hsa-Mir-589 3
  • Mir-589 3
  • MIRN589 3

External Ids for MIR589 Gene

Previous HGNC Symbols for MIR589 Gene

  • MIRN589

Previous GeneCards Identifiers for MIR589 Gene

  • GC07M005502
  • GC07M005535

Summaries for MIR589 Gene

Entrez Gene Summary for MIR589 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR589 Gene

MIR589 (MicroRNA 589) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNA targets in ECM and membrane receptors.

fRNAdb sequence ontologies for MIR589 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR589

Additional gene information for MIR589 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR589 Gene

Genomics for MIR589 Gene

GeneHancer (GH) Regulatory Elements for MIR589 Gene

Promoters and enhancers for MIR589 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I005494 Enhancer 1.1 Ensembl ENCODE 550.8 +0.5 506 2.4 CLOCK ATF1 ARID4B SIN3A ZNF2 ZNF48 ZNF213 ARID2 ZNF207 ZNF143 MIR589 TNRC18 ACTB AP5Z1 LOC100129484 FBXL18 GC07M005483 GC07P005444
GH07I005496 Enhancer 0.8 ENCODE 550.8 -1.6 -1593 1.1 HDAC1 PKNOX1 ZBTB40 TCF12 ZBTB2 ZBTB11 NCOA1 ZEB2 ZNF592 SMARCA4 MIR589 FBXL18 GC07P005444
GH07I005561 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 12.5 -66.9 -66931 2.6 ARNT ARID4B SIN3A ZNF2 CBX5 ZNF207 ZNF143 FOS SP3 SP5 ACTB FBXL18 MIR589 FSCN1 LOC100288712
GH07I005687 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.4 -198.8 -198809 15 HDGF PKNOX1 FOXA2 SMAD1 SIN3A FEZF1 IRF4 YY1 TCF12 ELK1 USP42 RNF216P1 C7orf26 ACTB ZNF316 RBAK FBXL18 MIR589 FSCN1 ENSG00000188365
GH07I005632 Enhancer 1.6 VISTA Ensembl ENCODE dbSUPER 11.9 -140.4 -140385 8 PKNOX1 FOXA2 ETS1 SCRT2 RCOR1 FOS EGR2 ZNF362 REST NR2F2 ACTB FBXL18 MIR589 C7orf26 USP42 ANKRD61 ZNF815P EIF2AK1 RNF216-IT1 FSCN1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR589 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR589 Gene

Genomic Locations for MIR589 Gene
chr7:5,495,819-5,495,917
(GRCh38/hg38)
Size:
99 bases
Orientation:
Minus strand
chr7:5,535,450-5,535,548
(GRCh37/hg19)

Genomic View for MIR589 Gene

Genes around MIR589 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR589 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR589 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR589 Gene

ORGUL Member Location for MIR589 Gene

ORGUL Member Location for MIR589 gene

Proteins for MIR589 Gene

Post-translational modifications for MIR589 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR589 Gene

Domains & Families for MIR589 Gene

Gene Families for MIR589 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR589: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR589 Gene

Function for MIR589 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR589 Gene

Localization for MIR589 Gene

Gene Ontology (GO) - Cellular Components for MIR589 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR589: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR589 Gene

Pathways & Interactions for MIR589 Gene

genes like me logo Genes that share pathways with MIR589: view

Pathways by source for MIR589 Gene

1 BioSystems pathway for MIR589 Gene

Interacting Proteins for MIR589 Gene

Gene Ontology (GO) - Biological Process for MIR589 Gene

None

No data available for SIGNOR curated interactions for MIR589 Gene

Drugs & Compounds for MIR589 Gene

No Compound Related Data Available

Transcripts for MIR589 Gene

fRNAdb Secondary structures for MIR589 Gene

  • hsa-miR-589-3p_MIMAT0003256_Homo_sapiens_miR-589-3p_mature

mRNA/cDNA for MIR589 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR589 Gene

No ASD Table

Relevant External Links for MIR589 Gene

GeneLoc Exon Structure for
MIR589
ECgene alternative splicing isoforms for
MIR589

Expression for MIR589 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR589 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR589 Gene:

MIR589
genes like me logo Genes that share expression patterns with MIR589: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR589 Gene

Orthologs for MIR589 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR589 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-589 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-589 34
  • 79 (a)
OneToOne
Species where no ortholog for MIR589 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR589 Gene

ENSEMBL:
Gene Tree for MIR589 (if available)
TreeFam:
Gene Tree for MIR589 (if available)

Paralogs for MIR589 Gene

No data available for Paralogs for MIR589 Gene

Variants for MIR589 Gene

Sequence variations from dbSNP and Humsavar for MIR589 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000178261 -- 5,497,452(-) T/C upstream_transcript_variant
rs1001533077 -- 5,495,606(-) G/A downstream_transcript_variant
rs1001690206 -- 5,495,787(-) T/C/G downstream_transcript_variant
rs1001854466 -- 5,496,518(-) C/G upstream_transcript_variant
rs1002537555 -- 5,496,367(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR589 Gene

Variant ID Type Subtype PubMed ID
nsv830890 CNV loss 17160897
nsv526194 CNV gain 19592680
nsv517558 CNV loss 19592680
nsv471304 CNV loss 18288195
nsv436904 CNV insertion 17901297
dgv3482n106 OTHER inversion 24896259

Additional Variant Information for MIR589 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR589

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR589 Gene

Disorders for MIR589 Gene

Additional Disease Information for MIR589

No disorders were found for MIR589 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR589 Gene

Publications for MIR589 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 58
  2. Peritoneal dialysis effluent miR-21 and miR-589 levels correlate with longitudinal change in peritoneal transport characteristics. (PMID: 27867039) Szeto CC … Li PK (Clinica chimica acta; international journal of clinical chemistry 2017) 3 58
  3. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  4. miR-589-5p inhibits MAP3K8 and suppresses CD90+ cancer stem cells in hepatocellular carcinoma. (PMID: 27835990) Zhang X … Li X (Journal of experimental & clinical cancer research : CR 2016) 3 58
  5. Microarray based analysis of gene regulation by microRNA in intervertebral disc degeneration. (PMID: 26134418) Hu P … Jia T (Molecular medicine reports 2015) 3 58

Products for MIR589 Gene

Sources for MIR589 Gene

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