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Aliases for MIR587 Gene

Subcategory (RNA class) for MIR587 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR587 Gene

  • MicroRNA 587 2 3 5
  • Hsa-Mir-587 3
  • MIRN587 3

External Ids for MIR587 Gene

ORGUL Members for MIR587 Gene

Previous HGNC Symbols for MIR587 Gene

  • MIRN587

Previous GeneCards Identifiers for MIR587 Gene

  • GC06P107339
  • GC06P107232

Summaries for MIR587 Gene

Entrez Gene Summary for MIR587 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR587 Gene

MIR587 (MicroRNA 587) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR587 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR587 Gene

Genomics for MIR587 Gene

GeneHancer (GH) Regulatory Elements for MIR587 Gene

Promoters and enhancers for MIR587 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I106781 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 550.8 -1.0 -978 3.6 NCOA3 SOX13 ESRRA FOXA2 NFIB JUN NEUROD1 MAX SIN3A RAD21 GC06P106785 GC06P106787 MIR587 QRSL1 LINC02532 GC06M106747 RNU6-117P
GH06I106785 Enhancer 0.4 dbSUPER 550.8 +1.4 1427 0.4 FOXA2 FOXA3 GC06P106785 GC06P106787 LINC02532 MIR587 GC06M106747
GH06I106729 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -52.9 -52941 3 ELF3 FOXA2 MLX DMAP1 ZNF48 RAD21 RARA YY1 CREM THAP11 MIR587 LINC02532 QRSL1 BEND3 GC06M106741 LOC105377927
GH06I106744 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.4 -38.1 -38050 4 PKNOX1 NEUROD1 SIN3A MZF1 RAD21 BRCA1 RFX5 SMARCC2 RCOR1 FOS MIR587 LINC02532 QRSL1 RNU6-117P GC06P106787 GC06M106747
GH06I106748 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.5 -33.8 -33816 4.4 NCOA3 CTCF PKNOX1 NFIB NEUROD1 BMI1 CTBP1 GATA3 ZNF143 FOSL2 LINC02532 MIR587 QRSL1 CRYBG1 RNU6-117P GC06P106787 GC06M106747
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR587 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR587 Gene

Genomic Locations for MIR587 Gene
chr6:106,784,125-106,784,220
(GRCh38/hg38)
Size:
96 bases
Orientation:
Plus strand
chr6:107,232,000-107,232,095
(GRCh37/hg19)

Genomic View for MIR587 Gene

Genes around MIR587 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR587 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR587 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR587 Gene

Proteins for MIR587 Gene

Post-translational modifications for MIR587 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR587 Gene

Domains & Families for MIR587 Gene

Gene Families for MIR587 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR587: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR587 Gene

Function for MIR587 Gene

Phenotypes From GWAS Catalog for MIR587 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR587 Gene

Localization for MIR587 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR587 Gene

Pathways & Interactions for MIR587 Gene

SuperPathways for MIR587 Gene

No Data Available

Interacting Proteins for MIR587 Gene

Gene Ontology (GO) - Biological Process for MIR587 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR587 Gene

Drugs & Compounds for MIR587 Gene

No Compound Related Data Available

Transcripts for MIR587 Gene

mRNA/cDNA for MIR587 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR587 Gene

No ASD Table

Relevant External Links for MIR587 Gene

GeneLoc Exon Structure for
MIR587
ECgene alternative splicing isoforms for
MIR587

Expression for MIR587 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR587 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR587 Gene:

MIR587
genes like me logo Genes that share expression patterns with MIR587: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR587 Gene

Orthologs for MIR587 Gene

Evolution for MIR587 Gene

ENSEMBL:
Gene Tree for MIR587 (if available)
TreeFam:
Gene Tree for MIR587 (if available)

No data available for Orthologs for MIR587 Gene

Paralogs for MIR587 Gene

No data available for Paralogs for MIR587 Gene

Variants for MIR587 Gene

Sequence variations from dbSNP and Humsavar for MIR587 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000540313 -- 106,782,222(+) A/C upstream_transcript_variant
rs1003410263 -- 106,783,966(+) C/A upstream_transcript_variant
rs1004823753 -- 106,782,561(+) T/G upstream_transcript_variant
rs1007624822 -- 106,784,502(+) C/T downstream_transcript_variant
rs1008209174 -- 106,783,197(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR587 Gene

Variant ID Type Subtype PubMed ID
nsv830756 CNV loss 17160897

Additional Variant Information for MIR587 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR587

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR587 Gene

Disorders for MIR587 Gene

Additional Disease Information for MIR587

No disorders were found for MIR587 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR587 Gene

Publications for MIR587 Gene

  1. MicroRNA-587 antagonizes 5-FU-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer. (PMID: 26247730) Zhang Y … Wang J (Cell death & disease 2015) 3 58
  2. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 58
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR587 Gene

Sources for MIR587 Gene

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