microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR586 Gene

Data sources for MIR586 Gene:

RNA type for MIR586 Gene

miRNA

Aliases for MIR586 Gene

External Ids for MIR586 Gene

Previous HGNC Symbols for MIR586 Gene

  • MIRN586

Previous GeneCards Identifiers for MIR586 Gene

  • GC06M045274
  • GC06M045165

Summaries for MIR586 Gene

Entrez Gene Summary for MIR586 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR586 Gene

MIR586 (MicroRNA 586) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR586 Gene

Additional gene information for MIR586 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR586 Gene

Genomics for MIR586 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR586 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J045196 Enhancer 0.6 UCNEbase 250.7 +1.4 1423 0.3 MAFF ZNF316 MAFK HLF YY1 EMSY MIR586 piR-41525-590 RUNX2 SUPT3H CDC5L
GH06J045164 Enhancer 0.6 Ensembl 12.3 +33.4 33369 0.8 JUND BATF IKZF1 NR2F1 JUNB FOS IKZF2 MTA2 EED DPF2 MIR586 ENSG00000219384 lnc-AARS2-3 RUNX2 SUPT3H CDC5L
GH06J045170 Enhancer 0.4 Ensembl 12.1 +27.3 27269 1 ZIC2 PRDM6 GLIS1 MZF1 MIR586 lnc-AARS2-3 ENSG00000219384 RUNX2 SUPT3H CDC5L
GH06J045200 Enhancer 0.8 Ensembl 0.7 -2.1 -2131 0.2 SSRP1 KLF9 CEBPA MXD4 HOMEZ KDM6A ZNF511 SAP130 MIER3 RARA MIR586 RF00994-900 RUNX2 SUPT3H CDC5L
GH06J045185 Enhancer 0.8 Ensembl ENCODE 0.4 +12.2 12169 1.2 NCOR1 CEBPA SMAD4 RFX5 RUNX1 TAL1 STAT5A TEAD4 CEBPG MEIS2 SUPT3H piR-41525-590 MIR586 RUNX2 CDC5L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR586 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR586 Gene

Latest Assembly
chr6:45,197,674-45,197,770
(GRCh38/hg38)
Size:
97 bases
Orientation:
Minus strand

Previous Assembly
chr6:45,165,411-45,165,507
(GRCh37/hg19 by Entrez Gene)
Size:
97 bases
Orientation:
Minus strand

chr6:45,165,411-45,165,507
(GRCh37/hg19 by Ensembl)
Size:
97 bases
Orientation:
Minus strand

Genomic View for MIR586 Gene

Genes around MIR586 on UCSC Golden Path with GeneCards custom track
MIR586 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR586 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR586 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR586 Gene

Proteins for MIR586 Gene

Post-translational modifications for MIR586 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR586 Gene

Domains & Families for MIR586 Gene

Gene Families for MIR586 Gene

HGNC:
genes like me logo Genes that share domains with MIR586: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR586 Gene

Function for MIR586 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR586 Gene

Localization for MIR586 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR586 Gene

Pathways & Interactions for MIR586 Gene

PathCards logo

SuperPathways for MIR586 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR586 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR586: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR586 Gene

Drugs & Compounds for MIR586 Gene

No Compound Related Data Available

Transcripts for MIR586 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR586 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS0000652679_9606 pre_miRNA 97 4

RefSeq: NR_030313,

Ensembl: ENST00000385035 (view in UCSC) ,

miRBase: MI0003594,

Rfam: RF00962,

URS000075D29B_9606 miRNA 22 2

RefSeq: NR_030313,

miRBase: MIMAT0003252,

URS0001BC8490_9606 pre_miRNA 97 1

Rfam: RF00962,

MIR586 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR586 Gene

No ASD Table

Relevant External Links for MIR586 Gene

GeneLoc Exon Structure for
MIR586

No data available for mRNA/cDNA for MIR586 Gene

Expression for MIR586 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR586 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR586

genes like me logo Genes that share expression patterns with MIR586: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR586 Gene

Orthologs for MIR586 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR586 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-586 30
  • 98 (a)
OneToOne
Species where no ortholog for MIR586 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR586 Gene

ENSEMBL:
Gene Tree for MIR586 (if available)
TreeFam:
Gene Tree for MIR586 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR586

Paralogs for MIR586 Gene

No data available for Paralogs for MIR586 Gene

Variants for MIR586 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR586 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR586 Gene

Variant ID Type Subtype PubMed ID
nsv1024370 CNV loss 25217958
nsv1032906 CNV loss 25217958

Additional Variant Information for MIR586 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR586
Leiden Open Variation Database (LOVD)
MIR586

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR586 Gene

Disorders for MIR586 Gene

Additional Disease Information for MIR586

No disorders were found for MIR586 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR586 Gene

Publications for MIR586 Gene

  1. Assessment of transmission distortion on chromosome 6p in healthy individuals using tagSNPs. (PMID: 19259136) Santos PS … Ziegler A (European journal of human genetics : EJHG 2009) 3 40
  2. Targeting of SGK1 by miR-576-3p Inhibits Lung Adenocarcinoma Migration and Invasion. (PMID: 30257988) Greenawalt EJ … Eischen CM (Molecular cancer research : MCR 2019) 3
  3. Plasma microRNA-586 is a new biomarker for acute graft-versus-host disease. (PMID: 26051902) Wang Y … Wan J (Annals of hematology 2015) 3
  4. Downregulation of microRNA-586 Inhibits Proliferation, Invasion and Metastasis and Promotes Apoptosis in Human Osteosarcoma U2-OS Cell Line. (PMID: 26580004) Yang L … Jia XJ (Cytogenetic and genome research 2015) 3
  5. miRNA expression profiling identifies DSPP regulators in cultured dental pulp cells. (PMID: 21687927) Huang X … Wu B (International journal of molecular medicine 2011) 3

Products for MIR586 Gene

Sources for MIR586 Gene