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Aliases for MIR586 Gene

Subcategory (RNA class) for MIR586 Gene


Quality Score for this RNA gene is


Aliases for MIR586 Gene

  • MicroRNA 586 2 3 5
  • Hsa-Mir-586 3
  • MIRN586 3

External Ids for MIR586 Gene

Previous HGNC Symbols for MIR586 Gene

  • MIRN586

Previous GeneCards Identifiers for MIR586 Gene

  • GC06M045274

Summaries for MIR586 Gene

Entrez Gene Summary for MIR586 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR586 Gene

MIR586 (MicroRNA 586) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR586 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

Additional gene information for MIR586 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR586 Gene

Genomics for MIR586 Gene

GeneHancer (GH) Regulatory Elements for MIR586 Gene

Promoters and enhancers for MIR586 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I045196 Enhancer 0.7 UCNEbase 550.8 +1.4 1423 0.3 MAFF ZNF316 HLF FOXP2 MAFK EMSY YY1 MIR586 GC06P045158 SUPT3H
GH06I045185 Enhancer 0.7 ENCODE 0.4 +12.2 12171 1.1 MEIS2 PKNOX1 ATF1 TEAD4 CEBPG RFX5 CHAMP1 FOXK2 NCOR1 NFE2 SUPT3H MIR586 GC06P045158
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR586 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR586 Gene

Genomic Locations for MIR586 Gene
97 bases
Minus strand

Genomic View for MIR586 Gene

Genes around MIR586 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR586 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR586 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR586 Gene

ORGUL Member Location for MIR586 Gene

ORGUL Member Location for MIR586 gene

Proteins for MIR586 Gene

Post-translational modifications for MIR586 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR586 Gene

Domains & Families for MIR586 Gene

Gene Families for MIR586 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR586: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR586 Gene

Function for MIR586 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR586 Gene

Localization for MIR586 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR586 Gene

Pathways & Interactions for MIR586 Gene

SuperPathways for MIR586 Gene

No Data Available

Interacting Proteins for MIR586 Gene

Gene Ontology (GO) - Biological Process for MIR586 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR586 Gene

Drugs & Compounds for MIR586 Gene

No Compound Related Data Available

Transcripts for MIR586 Gene

mRNA/cDNA for MIR586 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR586 Gene

No ASD Table

Relevant External Links for MIR586 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR586 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR586 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR586 Gene:

genes like me logo Genes that share expression patterns with MIR586: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR586 Gene

Orthologs for MIR586 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR586 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-586 34
  • 98 (a)
Species where no ortholog for MIR586 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR586 Gene

Gene Tree for MIR586 (if available)
Gene Tree for MIR586 (if available)

Paralogs for MIR586 Gene

No data available for Paralogs for MIR586 Gene

Variants for MIR586 Gene

Sequence variations from dbSNP and Humsavar for MIR586 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000930892 -- 45,197,437(-) T/C downstream_transcript_variant
rs1002532291 -- 45,199,120(-) C/A upstream_transcript_variant
rs1003242876 -- 45,199,443(-) A/C upstream_transcript_variant
rs1003525654 -- 45,197,688(-) A/G non_coding_transcript_variant
rs1003560563 -- 45,199,073(-) /GA upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR586 Gene

Variant ID Type Subtype PubMed ID
nsv1024370 CNV loss 25217958
nsv1032906 CNV loss 25217958

Additional Variant Information for MIR586 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR586 Gene

Disorders for MIR586 Gene

Additional Disease Information for MIR586

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR586 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR586 Gene

Publications for MIR586 Gene

  1. Assessment of transmission distortion on chromosome 6p in healthy individuals using tagSNPs. (PMID: 19259136) Santos PS … Ziegler A (European journal of human genetics : EJHG 2009) 3 44 58
  2. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 58
  3. Downregulation of microRNA-586 Inhibits Proliferation, Invasion and Metastasis and Promotes Apoptosis in Human Osteosarcoma U2-OS Cell Line. (PMID: 26580004) Yang L … Jia XJ (Cytogenetic and genome research 2015) 3 58
  4. Plasma microRNA-586 is a new biomarker for acute graft-versus-host disease. (PMID: 26051902) Wang Y … Wan J (Annals of hematology 2015) 3 58
  5. miRNA expression profiling identifies DSPP regulators in cultured dental pulp cells. (PMID: 21687927) Huang X … Wu B (International journal of molecular medicine 2011) 3 58

Products for MIR586 Gene

Sources for MIR586 Gene

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