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Aliases for MIR584 Gene

Subcategory (RNA class) for MIR584 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR584 Gene

  • MicroRNA 584 2 3 5
  • Hsa-Mir-584 3
  • MIRN584 3

External Ids for MIR584 Gene

Previous HGNC Symbols for MIR584 Gene

  • MIRN584

Previous GeneCards Identifiers for MIR584 Gene

  • GC05M148423
  • GC05M148441

Summaries for MIR584 Gene

Entrez Gene Summary for MIR584 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR584 Gene

MIR584 (MicroRNA 584) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR584 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR584

Additional gene information for MIR584 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR584 Gene

Genomics for MIR584 Gene

GeneHancer (GH) Regulatory Elements for MIR584 Gene

Promoters and enhancers for MIR584 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I149060 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.1 62 4.6 ATF1 PKNOX1 NFIB ARID4B SIN3A RCOR1 FOS SP5 CEBPB MIER2 SH3TC2 SH3TC2-DT MIR584 ABLIM3 GC05M149060 RNU6-732P GC05M149047
GH05I149133 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -73.0 -72985 3.6 FOXA2 RAD21 ZBTB40 RFX5 YY1 EGR1 FOS EGR2 SMARCC1 RXRA SH3TC2 AFAP1L1 MIR584 SH3TC2-DT RNU6-732P ENSG00000248647 ENSG00000253406 ABLIM3 GC05M149047 RN7SKP145
GH05I149001 Enhancer 1.2 Ensembl ENCODE dbSUPER 11 +59.6 59582 2.3 FOXA2 FEZF1 RAD21 ETS1 ZNF366 FOS ZNF398 SP1 NFIL3 GLIS1 SH3TC2 RNU6-732P MIR584 SH3TC2-DT ADRB2 ENSG00000248647 ENSG00000253406 GC05M149010 GC05M148982
GH05I149124 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.8 -65.5 -65474 6.2 NFIB ZSCAN4 NEUROD1 ZNF2 RAD21 ZNF143 FOS RCOR1 SMARCA5 ZNF654 SH3TC2 SH3TC2-DT MIR584 RNU6-732P AFAP1L1 ENSG00000253406 ENSG00000248647 ABLIM3 RN7SKP145 GC05M149117
GH05I149035 Enhancer 0.9 Ensembl dbSUPER 12.8 +26.7 26709 0.2 CTCF PKNOX1 ZBTB21 MAX CEBPG ZNF2 RAD21 ZNF335 ZBTB48 ZNF143 SH3TC2 RNU6-732P MIR584 SH3TC2-DT AFAP1L1 GC05M149060 GC05M149010
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR584 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR584 Gene

Genomic Locations for MIR584 Gene
chr5:149,062,313-149,062,409
(GRCh38/hg38)
Size:
97 bases
Orientation:
Minus strand
chr5:148,441,876-148,441,972
(GRCh37/hg19)

Genomic View for MIR584 Gene

Genes around MIR584 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR584 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR584 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR584 Gene

ORGUL Member Location for MIR584 Gene

ORGUL Member Location for MIR584 gene

Proteins for MIR584 Gene

Post-translational modifications for MIR584 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR584 Gene

Domains & Families for MIR584 Gene

Gene Families for MIR584 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR584: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR584 Gene

Function for MIR584 Gene

Gene Ontology (GO) - Molecular Function for MIR584 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II core binding IDA 25336585
genes like me logo Genes that share ontologies with MIR584: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR584 Gene

Localization for MIR584 Gene

Gene Ontology (GO) - Cellular Components for MIR584 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR584: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR584 Gene

Pathways & Interactions for MIR584 Gene

SuperPathways for MIR584 Gene

No Data Available

Interacting Proteins for MIR584 Gene

Gene Ontology (GO) - Biological Process for MIR584 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR584 Gene

Drugs & Compounds for MIR584 Gene

No Compound Related Data Available

Transcripts for MIR584 Gene

fRNAdb Secondary structures for MIR584 Gene

  • FR340342
  • hsa-miR-584-3p_MIMAT0022708_Homo_sapiens_miR-584-3p_mature

mRNA/cDNA for MIR584 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR584 Gene

No ASD Table

Relevant External Links for MIR584 Gene

GeneLoc Exon Structure for
MIR584
ECgene alternative splicing isoforms for
MIR584

Expression for MIR584 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR584 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR584 Gene:

MIR584
genes like me logo Genes that share expression patterns with MIR584: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR584 Gene

Orthologs for MIR584 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR584 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-584 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-584-3 34
  • 68 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 61 (a)
ManyToMany
Species where no ortholog for MIR584 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR584 Gene

ENSEMBL:
Gene Tree for MIR584 (if available)
TreeFam:
Gene Tree for MIR584 (if available)

Paralogs for MIR584 Gene

No data available for Paralogs for MIR584 Gene

Variants for MIR584 Gene

Sequence variations from dbSNP and Humsavar for MIR584 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs149762843 uncertain-significance, Charcot-Marie-Tooth disease, type IV, Mononeuropathy of the Median Nerve, not specified, Charcot-Marie-Tooth, Type 4 149,062,992(-) G/A/T upstream_transcript_variant
rs80338918 pathogenic, Charcot-Marie-Tooth disease, type 4C 149,062,995(-) CCC/CC upstream_transcript_variant
rs864309709 likely-pathogenic, Charcot-Marie-Tooth disease, type 4C 149,063,022(-) T/C/G upstream_transcript_variant
rs886060200 uncertain-significance, Charcot-Marie-Tooth, Type 4, Mononeuropathy of the Median Nerve 149,063,114(-) G/A upstream_transcript_variant
rs879254057 likely-pathogenic, not provided 149,062,966(-) CTC/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR584 Gene

Variant ID Type Subtype PubMed ID
nsv830517 CNV gain 17160897

Additional Variant Information for MIR584 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR584

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR584 Gene

Disorders for MIR584 Gene

Additional Disease Information for MIR584

No disorders were found for MIR584 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR584 Gene

Publications for MIR584 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 58
  2. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  3. MicroRNA-584-3p, a novel tumor suppressor and prognostic marker, reduces the migration and invasion of human glioma cells by targeting hypoxia-induced ROCK1. (PMID: 26715733) Xue H … Li G (Oncotarget 2016) 3 58
  4. A 3'UTR polymorphism marks differential KLRG1 mRNA levels through disruption of a miR-584-5p binding site and associates with pemphigus foliaceus susceptibility. (PMID: 27424220) Cipolla GA … Petzl-Erler ML (Biochimica et biophysica acta 2016) 3 58
  5. Upregulation of microRNA‑335 and microRNA‑584 contributes to the pathogenesis of severe preeclampsia through downregulation of endothelial nitric oxide synthase. (PMID: 26133786) Jiang F … Wang X (Molecular medicine reports 2015) 3 58

Products for MIR584 Gene

Sources for MIR584 Gene

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