microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR582 Gene

RNA type for MIR582 Gene

miRNA

Aliases for MIR582 Gene

External Ids for MIR582 Gene

Previous HGNC Symbols for MIR582 Gene

  • MIRN582

Previous GeneCards Identifiers for MIR582 Gene

  • GC05M059036
  • GC05M058999

Summaries for MIR582 Gene

Entrez Gene Summary for MIR582 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR582 Gene

MIR582 (MicroRNA 582) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR582 include Mesothelioma, Malignant and Leiomyoma, Uterine.

Rfam classification for MIR582 Gene

Additional gene information for MIR582 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR582 Gene

Genomics for MIR582 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR582 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J059704 Enhancer 0.2 Ensembl 250.7 -1.8 -1798 1 MIR582 NONHSAG040470.2 LOC105378988 lnc-DEPDC1B-5 PDE4D
GH05J059763 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 -63.2 -63156 6.6 ZNF600 ATF2 ZNF10 ZSCAN16 BRCA1 ZIC2 YY1 CEBPB DEK FEZF1 PDE4D MIR582 LOC105378988 NONHSAG040470.2 lnc-DEPDC1B-5
GH05J059743 Enhancer 1.4 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 12.1 -41.6 -41574 4 ZNF600 ZNF580 ATF2 ZSCAN16 BRCA1 ZIC2 CEBPB FEZF1 ZNF639 ZNF341 MIR582 PDE4D LOC105378988 NONHSAG040470.2 lnc-DEPDC1B-5
GH05J059756 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 10.9 -55.4 -55406 6 ZNF600 ZNF580 ATF3 YY1 CEBPB FEZF1 ZNF341 EP300 FOXA2 ZNF610 MIR582 LOC105378988 NONHSAG040470.2 lnc-DEPDC1B-5 PDE4D
GH05J059559 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas 10.2 +140.8 140802 7 CEBPA ZNF10 ZIC2 YY1 CEBPB ELK1 FEZF1 SIX4 MAX ZNF217 LOC107986347 MIR582 piR-43103-047 HSALNG0042082 lnc-DEPDC1B-5 RAB3C PDE4D
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR582 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR582 Gene

Latest Assembly
chr5:59,703,606-59,703,703
(GRCh38/hg38)
Size:
98 bases
Orientation:
Minus strand

Previous Assembly
chr5:58,999,432-58,999,529
(GRCh37/hg19 by Entrez Gene)
Size:
98 bases
Orientation:
Minus strand

chr5:58,999,432-58,999,529
(GRCh37/hg19 by Ensembl)
Size:
98 bases
Orientation:
Minus strand

Genomic View for MIR582 Gene

Genes around MIR582 on UCSC Golden Path with GeneCards custom track
MIR582 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR582 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR582 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR582 Gene

Proteins for MIR582 Gene

Post-translational modifications for MIR582 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR582 Gene

Domains & Families for MIR582 Gene

Gene Families for MIR582 Gene

HGNC:
genes like me logo Genes that share domains with MIR582: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR582 Gene

Function for MIR582 Gene

Phenotypes From GWAS Catalog for MIR582 Gene

Gene Ontology (GO) - Molecular Function for MIR582 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20829195
genes like me logo Genes that share ontologies with MIR582: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR582 Gene

Localization for MIR582 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR582 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR582 Gene

Pathways & Interactions for MIR582 Gene

PathCards logo

SuperPathways for MIR582 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR582 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
genes like me logo Genes that share ontologies with MIR582: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR582 Gene

Drugs & Compounds for MIR582 Gene

(1) Drugs for MIR582 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Quetiapine Approved Pharma 0
genes like me logo Genes that share compounds with MIR582: view

Transcripts for MIR582 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR582 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00000B0E50_9606 miRNA 23 6

RefSeq: NR_030308,

LncBase: hsa-miR-582-5p,

miRBase: MIMAT0003247,

MirGeneDB: Hsa-Mir-582_5p,

TarBase: hsa-miR-582-5p,

ENA: LM379863.1:1..23:ncRNA, LM609558.1:16..38:ncRNA,

URS000068CA2F_9606 pre_miRNA 98 5

RefSeq: NR_030308,

Ensembl: ENST00000365731 (view in UCSC) ,

miRBase: MI0003589,

Rfam: RF00927,

ENA: LM609558.1:1..98:precursor_RNA,

URS00002573C3_9606 miRNA 22 5

RefSeq: NR_030308,

LncBase: hsa-miR-582-3p,

miRBase: MIMAT0004797,

TarBase: hsa-miR-582-3p,

ENA: LM380408.1:1..22:ncRNA, LM609558.1:53..74:ncRNA,

URS0001BC9475_9606 pre_miRNA 98 1

Rfam: RF00927,

URS0000EFD200_9606 pre_miRNA 61 1

MirGeneDB: Hsa-Mir-582,

MIR582 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR582 Gene

No ASD Table

Relevant External Links for MIR582 Gene

GeneLoc Exon Structure for
MIR582

No data available for mRNA/cDNA for MIR582 Gene

Expression for MIR582 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR582 Gene

genes like me logo Genes that share expression patterns with MIR582: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR582 Gene

Orthologs for MIR582 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR582 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-582 30
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir582 30
  • 94 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-582 30
  • 94 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-582 30
  • 93 (a)
OneToOne
Species where no ortholog for MIR582 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR582 Gene

ENSEMBL:
Gene Tree for MIR582 (if available)
TreeFam:
Gene Tree for MIR582 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR582

Paralogs for MIR582 Gene

No data available for Paralogs for MIR582 Gene

Variants for MIR582 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR582 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR582 Gene

Variant ID Type Subtype PubMed ID
nsv462190 CNV gain 19166990
nsv462191 CNV loss 19166990
nsv598258 CNV gain 21841781
nsv598259 CNV loss 21841781

Additional Variant Information for MIR582 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR582
Leiden Open Variation Database (LOVD)
MIR582

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR582 Gene

Disorders for MIR582 Gene

MalaCards: The human disease database

(13) MalaCards diseases for MIR582 Gene - From: MID and COP

Disorder Aliases PubMed IDs
mesothelioma, malignant
  • mesom
leiomyoma, uterine
  • ul
functioning pituitary adenoma
  • secretory adenoma of the pituitary gland
pituitary gland disease
  • pituitary disease
bladder disease
  • urinary bladder disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR582

genes like me logo Genes that share disorders with MIR582: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR582 Gene

Publications for MIR582 Gene

  1. Therapeutic effects of microRNA-582-5p and -3p on the inhibition of bladder cancer progression. (PMID: 23295946) Uchino K … Ochiya T (Molecular therapy : the journal of the American Society of Gene Therapy 2013) 2 3
  2. The miR-582/CD1B Axis Is Involved in Regulation of Dendritic Cells and Is Associated with Clinical Outcomes in Advanced Lung Adenocarcinoma. (PMID: 32258122) Guo J … Jiang D (BioMed research international 2020) 3
  3. Knockdown of circ_HIPK3 inhibits tumorigenesis of hepatocellular carcinoma via the miR-582-3p/DLX2 axis. (PMID: 32977948) Zhang H … Deng J (Biochemical and biophysical research communications 2020) 3
  4. Long non-coding RNA NNT-AS1 regulates proliferation, apoptosis, inflammation and airway remodeling of chronic obstructive pulmonary disease via targeting miR-582-5p/FBXO11 axis. (PMID: 32768929) Mei J … Wang J (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020) 3
  5. LINC00641/miR-582-5p mediate oxaliplatin resistance by activating autophagy in gastric adenocarcinoma. (PMID: 32917936) Hu Y … Zhang X (Scientific reports 2020) 3

Products for MIR582 Gene

Sources for MIR582 Gene