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Aliases for MIR581 Gene

Subcategory (RNA class) for MIR581 Gene


Quality Score for this RNA gene is


Aliases for MIR581 Gene

  • MicroRNA 581 2 3 5
  • Hsa-Mir-581 3
  • MIRN581 3

External Ids for MIR581 Gene

Previous HGNC Symbols for MIR581 Gene

  • MIRN581

Previous GeneCards Identifiers for MIR581 Gene

  • GC05M053284

Summaries for MIR581 Gene

Entrez Gene Summary for MIR581 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR581 Gene

MIR581 (MicroRNA 581) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR581 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

Additional gene information for MIR581 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR581 Gene

Genomics for MIR581 Gene

GeneHancer (GH) Regulatory Elements for MIR581 Gene

Promoters and enhancers for MIR581 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I053942 Enhancer 0.7 ENCODE 0.4 +8.6 8633 0.2 PKNOX1 JUN TAL1 CEBPG FOSL1 TCF12 ZFHX2 EGR1 CBFA2T2 TRIM24 MIR581 PIR41245 ARL15
GH05I054021 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 0.2 -70.6 -70605 1.1 HDAC1 MEIS2 LEF1 PKNOX1 ETV1 CEBPG E4F1 IRF9 VEZF1 ATF7 RN7SL801P MIR581 ARL15
GH05I054013 Enhancer 1.2 FANTOM5 Ensembl ENCODE 0.2 -62.1 -62137 1.1 PKNOX1 CHAMP1 ZNF280A CBX5 RCOR1 FOS CEBPB ZNF398 ATF4 MAFF ARL15 RN7SL801P MIR581
GH05I054016 Enhancer 1 UCNEbase ENCODE dbSUPER 0.2 -66.8 -66802 4.2 SP1 POU5F1 RN7SL801P MIR581 ARL15
GH05I054007 Enhancer 1 ENCODE dbSUPER 0.2 -56.8 -56783 1 ELF3 FOXA2 RAD21 RARA YY1 FOS CREM MIXL1 RXRA CEBPB RN7SL801P MIR581 ARL15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR581 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR581 Gene

Genomic Locations for MIR581 Gene
96 bases
Minus strand

Genomic View for MIR581 Gene

Genes around MIR581 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR581 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR581 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR581 Gene

ORGUL Member Location for MIR581 Gene

ORGUL Member Location for MIR581 gene

Proteins for MIR581 Gene

Post-translational modifications for MIR581 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR581 Gene

Domains & Families for MIR581 Gene

Gene Families for MIR581 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR581: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR581 Gene

Function for MIR581 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR581 Gene

Localization for MIR581 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR581 Gene

Pathways & Interactions for MIR581 Gene

SuperPathways for MIR581 Gene

No Data Available

Interacting Proteins for MIR581 Gene

Gene Ontology (GO) - Biological Process for MIR581 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR581 Gene

Drugs & Compounds for MIR581 Gene

No Compound Related Data Available

Transcripts for MIR581 Gene

mRNA/cDNA for MIR581 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR581 Gene

No ASD Table

Relevant External Links for MIR581 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR581 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR581 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR581 Gene:

genes like me logo Genes that share expression patterns with MIR581: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR581 Gene

Orthologs for MIR581 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR581 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-581 34
  • 99 (a)
Species where no ortholog for MIR581 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR581 Gene

Gene Tree for MIR581 (if available)
Gene Tree for MIR581 (if available)

Paralogs for MIR581 Gene

No data available for Paralogs for MIR581 Gene

Variants for MIR581 Gene

Sequence variations from dbSNP and Humsavar for MIR581 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1001329501 -- 53,953,155(-) A/G upstream_transcript_variant
rs1002466483 -- 53,951,271(-) G/A downstream_transcript_variant
rs1003618811 -- 53,952,127(-) G/A upstream_transcript_variant
rs1004785907 -- 53,952,355(-) T/A upstream_transcript_variant
rs10052240 -- 53,951,160(-) T/A/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR581 Gene

Variant ID Type Subtype PubMed ID
nsv830299 CNV gain 17160897
dgv5666n100 CNV gain 25217958

Additional Variant Information for MIR581 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR581 Gene

Disorders for MIR581 Gene

Additional Disease Information for MIR581

No disorders were found for MIR581 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR581 Gene

Publications for MIR581 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 58
  2. MicroRNA-581 promotes hepatitis B virus surface antigen expression by targeting Dicer and EDEM1. (PMID: 24913918) Wang YQ … Tang KF (Carcinogenesis 2014) 3 58
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR581 Gene

Sources for MIR581 Gene

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