microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR580 Gene

Subcategory (RNA class) for MIR580 Gene

miRNA

Number of RNA Genes sources:

4 / 17

Aliases for MIR580 Gene

  • MicroRNA 580 2 3 5
  • Hsa-Mir-580 2 3 178
  • MIR580 2 5
  • Hsa-MiR-580-3p 173
  • MIMAT0003245 50
  • MIMAT0026617 50
  • MI0003587 50
  • MIRN580 3
  • RF01000 168

External Ids for MIR580 Gene

Previous HGNC Symbols for MIR580 Gene

  • MIRN580

Summaries for MIR580 Gene

Entrez Gene Summary for MIR580 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR580 Gene

MIR580 (MicroRNA 580) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR580 Gene

Additional gene information for MIR580 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR580 Gene

Genomics for MIR580 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR580 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J036146 Enhancer 0.5 Ensembl 600.7 +1.2 1188 0.4 ZSCAN4 ZNF335 ATF4 ZMYM3 ZNF121 MIR580 UGT3A2 lnc-NADK2-1 LMBRD2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR580 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR580 Gene

Genomic Locations for MIR580 Gene
chr5:36,147,892-36,147,988
(GRCh38/hg38)
Size:
97 bases
Orientation:
Minus strand
chr5:36,147,994-36,148,090
(GRCh37/hg19)
Size:
97 bases
Orientation:
Minus strand

Genomic View for MIR580 Gene

Genes around MIR580 on UCSC Golden Path with GeneCards custom track
MIR580 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR580 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR580 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR580 Gene

Proteins for MIR580 Gene

Post-translational modifications for MIR580 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR580 Gene

Domains & Families for MIR580 Gene

Gene Families for MIR580 Gene

HGNC:
genes like me logo Genes that share domains with MIR580: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR580 Gene

Function for MIR580 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR580 Gene

Localization for MIR580 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR580 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR580 Gene

Pathways & Interactions for MIR580 Gene

PathCards logo

SuperPathways for MIR580 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR580 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR580: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR580 Gene

Drugs & Compounds for MIR580 Gene

No Compound Related Data Available

Transcripts for MIR580 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR580 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00006315BE_9606 precursor_RNA 97 5

HGNC: 32836,

RefSeq: NR_030306,

Ensembl: ENST00000385023 (view in UCSC) ,

miRBase: MI0003587,

Rfam: RF01000,

URS000075D9A5_9606 miRNA 22 4

RefSeq: NR_030306,

miRBase: MIMAT0003245,

MirGeneDB: Hsa-Mir-580_3p,

TarBase: hsa-miR-580-3p,

URS00008E39A0_9606 miRNA 22 3

RefSeq: NR_030306,

miRBase: MIMAT0026617,

MirGeneDB: Hsa-Mir-580_5p,

URS0000EFE322_9606 precursor_RNA 62 1

MirGeneDB: Hsa-Mir-580,

MIR580 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR580 Gene

No ASD Table

Relevant External Links for MIR580 Gene

GeneLoc Exon Structure for
MIR580

No data available for mRNA/cDNA for MIR580 Gene

Expression for MIR580 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR580 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR580

genes like me logo Genes that share expression patterns with MIR580: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR580 Gene

Orthologs for MIR580 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR580 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-580 31
  • 99 (a)
OneToOne
Species where no ortholog for MIR580 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR580 Gene

ENSEMBL:
Gene Tree for MIR580 (if available)
TreeFam:
Gene Tree for MIR580 (if available)

Paralogs for MIR580 Gene

No data available for Paralogs for MIR580 Gene

Variants for MIR580 Gene

Additional dbSNP identifiers (rs#s) for MIR580 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR580 Gene

Variant ID Type Subtype PubMed ID
esv3604707 CNV gain 21293372
nsv4795 CNV deletion 18451855
nsv830262 CNV gain 17160897

Additional Variant Information for MIR580 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR580

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR580 Gene

Disorders for MIR580 Gene

No disorders were found for MIR580 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR580 Gene

Publications for MIR580 Gene

  1. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J … Kaessmann H (Genome research 2013) 3
  2. Translational control of TWIST1 expression in MCF-10A cell lines recapitulating breast cancer progression. (PMID: 22266852) Nairismägi ML … Groisman I (Oncogene 2012) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3
  4. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 3

Products for MIR580 Gene

Sources for MIR580 Gene