microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR578 Gene

Subcategory (RNA class) for MIR578 Gene

miRNA

Number of RNA Genes sources:

2 / 17

Aliases for MIR578 Gene

  • MicroRNA 578 2 3 5
  • Hsa-Mir-578 2 3
  • MIR578 2 5
  • MIMAT0003243 50
  • MI0003585 50
  • MIRN578 3
  • RF00971 168

External Ids for MIR578 Gene

Previous HGNC Symbols for MIR578 Gene

  • MIRN578

Previous GeneCards Identifiers for MIR578 Gene

  • GC04P166527
  • GC04P166307

Summaries for MIR578 Gene

Entrez Gene Summary for MIR578 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR578 Gene

MIR578 (MicroRNA 578) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR578 include Neovascular Glaucoma.

Rfam classification for MIR578 Gene

Additional gene information for MIR578 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR578 Gene

Genomics for MIR578 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR578 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J165383 Enhancer 0.9 Ensembl ENCODE CraniofacialAtlas 600.7 -1.9 -1941 2.2 CTCF RAD21 FOXA2 OSR2 MEF2D NFIC PRDM6 NFIA SMARCA4 CHD2 MIR578 CPE TLL1
GH04J165386 Enhancer 0.2 CraniofacialAtlas 600.7 +0.6 607 0.4 MIR578 KY994054-047 CPE TLL1
GH04J165385 Enhancer 0.2 Ensembl 600.7 -0.3 -341 0.2 MIR578 CPE TLL1
GH04J165323 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.3 -58.1 -58102 10.1 BRCA1 SP1 CREB1 GATAD2A HNRNPL REST TFE3 RFX1 SOX13 IKZF1 MSMO1 lnc-GK3P-6 KLHL2 TMEM192 NACA3P MIR578 RPL21P51 CPE LOC105377519
GH04J165439 Enhancer 1.2 FANTOM5 Ensembl ENCODE 10.8 +54.0 53959 2.8 CREB1 PRDM10 ZNF629 ZNF692 ZIC2 ZSCAN4 PATZ1 ZNF341 ATF7 ZNF561 CPE MIR578 HADHAP1 FAM218A RF00017-4449 TLL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR578 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR578 Gene

Genomic Locations for MIR578 Gene
chr4:165,386,242-165,386,337
(GRCh38/hg38)
Size:
96 bases
Orientation:
Plus strand
chr4:166,307,394-166,307,489
(GRCh37/hg19)
Size:
96 bases
Orientation:
Plus strand

Genomic View for MIR578 Gene

Genes around MIR578 on UCSC Golden Path with GeneCards custom track
MIR578 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR578 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR578 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR578 Gene

Proteins for MIR578 Gene

Post-translational modifications for MIR578 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR578 Gene

Domains & Families for MIR578 Gene

Gene Families for MIR578 Gene

HGNC:
genes like me logo Genes that share domains with MIR578: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR578 Gene

Function for MIR578 Gene

Phenotypes From GWAS Catalog for MIR578 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR578 Gene

Localization for MIR578 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR578 Gene

Pathways & Interactions for MIR578 Gene

PathCards logo

SuperPathways for MIR578 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR578 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR578: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR578 Gene

Drugs & Compounds for MIR578 Gene

No Compound Related Data Available

Transcripts for MIR578 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR578 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000064EB09_9606 precursor_RNA 96 5

HGNC: 32834,

RefSeq: NR_030304,

Ensembl: ENST00000384828 (view in UCSC) ,

miRBase: MI0003585,

Rfam: RF00971,

URS000075B968_9606 miRNA 21 2

RefSeq: NR_030304,

miRBase: MIMAT0003243,

MIR578 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR578 Gene

No ASD Table

Relevant External Links for MIR578 Gene

GeneLoc Exon Structure for
MIR578

No data available for mRNA/cDNA for MIR578 Gene

Expression for MIR578 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR578 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR578

genes like me logo Genes that share expression patterns with MIR578: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR578 Gene

Orthologs for MIR578 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR578 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia cfa-mir-578 31
  • 32 (a)
OneToOne
Species where no ortholog for MIR578 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR578 Gene

ENSEMBL:
Gene Tree for MIR578 (if available)
TreeFam:
Gene Tree for MIR578 (if available)

Paralogs for MIR578 Gene

No data available for Paralogs for MIR578 Gene

Variants for MIR578 Gene

Additional dbSNP identifiers (rs#s) for MIR578 Gene

Additional Variant Information for MIR578 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR578

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR578 Gene

Disorders for MIR578 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR578 Gene - From: DISEASES

Disorder Aliases PubMed IDs
neovascular glaucoma
  • secondary angle-closure glaucoma with rubeosis
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR578: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR578 Gene

Publications for MIR578 Gene

  1. MiR-578 and miR-573 as potential players in BRCA-related breast cancer angiogenesis. (PMID: 25333258) Danza K … Tommasi S (Oncotarget 2015) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3
  3. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 3

Products for MIR578 Gene

Sources for MIR578 Gene