microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR575 Gene

Subcategory (RNA class) for MIR575 Gene

miRNA

Number of RNA Genes sources:

4 / 17

Aliases for MIR575 Gene

  • MicroRNA 575 2 3 5
  • Hsa-Mir-575 2 3
  • Hsa-MiR-575 163 173
  • MIR575 2 5
  • MIMAT0003240 50
  • MI0003582 50
  • MIRN575 3
  • RF02011 168

External Ids for MIR575 Gene

Previous HGNC Symbols for MIR575 Gene

  • MIRN575

Previous GeneCards Identifiers for MIR575 Gene

  • GC04M083896
  • GC04M083674

Summaries for MIR575 Gene

Entrez Gene Summary for MIR575 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR575 Gene

MIR575 (MicroRNA 575) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR575 include Systemic Lupus Erythematosus.

Rfam classification for MIR575 Gene

Additional gene information for MIR575 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR575 Gene

Genomics for MIR575 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR575 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J082811 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.9 -58.7 -58671 1.4 TEAD4 ZNF629 ZIC2 PATZ1 SP1 ZNF341 CEBPA EZH2 FOXA2 TSHZ1 THAP9-AS1 MIR575 THAP9 lnc-THAP9-1 RF00017-4347 SCD5
GH04J082710 Enhancer 1 Ensembl ENCODE dbSUPER 11.4 +43.1 43129 2.2 GATAD2A SOX13 ZNF341 TCF7 FOXP1 CTCF SMAD4 TFAP4 SREBF1 JUN TMEM150C MIR575 GPAT3 piR-53610 SCD5
GH04J082715 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.2 +37.2 37243 2 CREB1 GABPA CEBPA SCRT2 SOX13 SCRT1 BCL6 NFIL3 CEBPG CEBPB TMEM150C MIR575 piR-53610 SCD5
GH04J082704 Enhancer 0.7 Ensembl ENCODE dbSUPER 11.4 +47.1 47129 2.2 FEZF1 KAT2B SMARCA4 TMEM150C MIR575 PQLC1P2 piR-53610 SCD5
GH04J082686 Enhancer 0.7 Ensembl ENCODE dbSUPER 11.8 +65.6 65647 1.8 NR2F1 EBF1 MIR575 PQLC1P2 TMEM150C GPAT3 lnc-TMEM150C-6 SCD5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR575 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR575 Gene

Genomic Locations for MIR575 Gene
chr4:82,753,337-82,753,430
(GRCh38/hg38)
Size:
94 bases
Orientation:
Minus strand
chr4:83,674,490-83,674,583
(GRCh37/hg19)
Size:
94 bases
Orientation:
Minus strand

Genomic View for MIR575 Gene

Genes around MIR575 on UCSC Golden Path with GeneCards custom track
MIR575 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR575 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR575 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR575 Gene

Proteins for MIR575 Gene

Post-translational modifications for MIR575 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR575 Gene

Domains & Families for MIR575 Gene

Gene Families for MIR575 Gene

HGNC:
genes like me logo Genes that share domains with MIR575: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR575 Gene

Function for MIR575 Gene

Phenotypes From GWAS Catalog for MIR575 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR575 Gene

Localization for MIR575 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR575 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR575 Gene

Pathways & Interactions for MIR575 Gene

PathCards logo

SuperPathways for MIR575 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR575 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR575: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR575 Gene

Drugs & Compounds for MIR575 Gene

No Compound Related Data Available

Transcripts for MIR575 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR575 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000064FA6C_9606 precursor_RNA 94 5

HGNC: 32831,

RefSeq: NR_030301,

Ensembl: ENST00000385013 (view in UCSC) ,

miRBase: MI0003582,

Rfam: RF02011,

URS000075C5FB_9606 miRNA 19 4

RefSeq: NR_030301,

LncBase: hsa-miR-575,

miRBase: MIMAT0003240,

TarBase: hsa-miR-575,

MIR575 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR575 Gene

No ASD Table

Relevant External Links for MIR575 Gene

GeneLoc Exon Structure for
MIR575

No data available for mRNA/cDNA for MIR575 Gene

Expression for MIR575 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR575 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR575

genes like me logo Genes that share expression patterns with MIR575: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR575 Gene

Orthologs for MIR575 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR575 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-575 31
  • 100 (a)
OneToOne
Species where no ortholog for MIR575 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR575 Gene

ENSEMBL:
Gene Tree for MIR575 (if available)
TreeFam:
Gene Tree for MIR575 (if available)

Paralogs for MIR575 Gene

No data available for Paralogs for MIR575 Gene

Variants for MIR575 Gene

Additional dbSNP identifiers (rs#s) for MIR575 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR575 Gene

Variant ID Type Subtype PubMed ID
nsv1006474 CNV gain 25217958
nsv594744 CNV gain 21841781

Additional Variant Information for MIR575 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR575

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR575 Gene

Disorders for MIR575 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR575 Gene - From: miR2Disease

Disorder Aliases PubMed IDs
systemic lupus erythematosus
  • sle
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR575

genes like me logo Genes that share disorders with MIR575: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR575 Gene

Publications for MIR575 Gene

  1. MiRNA-575 suppresses angiogenesis by targeting Rab5-MEK-ERK pathway in endothelial cells. (PMID: 30333257) Zhao X … Fang N (Bioscience reports 2019) 3
  2. MicroRNA-575 regulates development of gastric cancer by targeting PTEN. (PMID: 30844657) Wang YN … Cheng SJ (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3
  3. Long noncoding RNA MIR31HG inhibits hepatocellular carcinoma proliferation and metastasis by sponging microRNA-575 to modulate ST7L expression. (PMID: 30176933) Yan S … Tang H (Journal of experimental & clinical cancer research : CR 2018) 3
  4. MicroRNA-575 targets BLID to promote growth and invasion of non-small cell lung cancer cells. (PMID: 25728273) Wang H … Shao Y (FEBS letters 2015) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR575 Gene

Sources for MIR575 Gene