microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR574 Gene

Subcategory (RNA class) for MIR574 Gene

miRNA

Aliases for MIR574 Gene

External Ids for MIR574 Gene

Previous HGNC Symbols for MIR574 Gene

  • MIRN574

Previous GeneCards Identifiers for MIR574 Gene

  • GC04U900958
  • GC04P038554
  • GC04P038869

Summaries for MIR574 Gene

Entrez Gene Summary for MIR574 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR574 Gene

MIR574 (MicroRNA 574) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR574 include Spinal Chordoma and Fragile X-Associated Tremor/Ataxia Syndrome.

Rfam classification for MIR574 Gene

Additional gene information for MIR574 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR574 Gene

Genomics for MIR574 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR574 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR574 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR574 Gene

Latest Assembly
chr4:38,868,032-38,868,127
(GRCh38/hg38)
Size:
96 bases
Orientation:
Plus strand

Previous Assembly
chr4:38,869,653-38,869,748
(GRCh37/hg19 by Entrez Gene)
Size:
96 bases
Orientation:
Plus strand

chr4:38,869,653-38,869,748
(GRCh37/hg19 by Ensembl)
Size:
96 bases
Orientation:
Plus strand

Genomic View for MIR574 Gene

Genes around MIR574 on UCSC Golden Path with GeneCards custom track
MIR574 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR574 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR574 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR574 Gene

Proteins for MIR574 Gene

Post-translational modifications for MIR574 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR574 Gene

Domains & Families for MIR574 Gene

Gene Families for MIR574 Gene

HGNC:
genes like me logo Genes that share domains with MIR574: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR574 Gene

Function for MIR574 Gene

Phenotypes From GWAS Catalog for MIR574 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR574 Gene

Localization for MIR574 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR574 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR574 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR574: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR574 Gene

Pathways & Interactions for MIR574 Gene

PathCards logo

SuperPathways for MIR574 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR574 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR574: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR574 Gene

Drugs & Compounds for MIR574 Gene

No Compound Related Data Available

Transcripts for MIR574 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR574 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00001CF056_9606 miRNA 22 6

RefSeq: NR_030300,

LncBase: hsa-miR-574-3p,

miRBase: MIMAT0003239,

MirGeneDB: Hsa-Mir-574_3p,

TarBase: hsa-miR-574-3p,

ENA: LM379859.1:1..22:ncRNA, LM609554.1:61..82:ncRNA,

URS000057466C_9606 miRNA 23 5

RefSeq: NR_030300,

LncBase: hsa-miR-574-5p,

miRBase: MIMAT0004795,

TarBase: hsa-miR-574-5p,

ENA: LM380406.1:1..23:ncRNA, LM609554.1:25..47:ncRNA,

URS000075BE91_9606 precursor_RNA 96 4

RefSeq: NR_030300,

Ensembl: ENST00000385209 (view in UCSC) ,

miRBase: MI0003581,

ENA: LM609554.1:1..96:precursor_RNA,

URS0000632BB1_9606 precursor_RNA 78 1

Rfam: RF00929,

URS0001BC45FE_9606 pre_miRNA 78 1

Rfam: RF00929,

MIR574 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR574 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR574 Gene

No ASD Table

Relevant External Links for MIR574 Gene

GeneLoc Exon Structure for
MIR574

Expression for MIR574 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR574 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR574

genes like me logo Genes that share expression patterns with MIR574: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR574 Gene

Orthologs for MIR574 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR574 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia cfa-mir-574 31
  • 98 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir574 31
  • 95 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 69 (a)
OneToMany
-- 31
  • 58 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 65 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 56 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 54 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 54 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii CU459159.1 31
  • 51 (a)
ManyToMany
Species where no ortholog for MIR574 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR574 Gene

ENSEMBL:
Gene Tree for MIR574 (if available)
TreeFam:
Gene Tree for MIR574 (if available)

Paralogs for MIR574 Gene

No data available for Paralogs for MIR574 Gene

Variants for MIR574 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR574 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR574 Gene

Variant ID Type Subtype PubMed ID
nsv594010 CNV loss 21841781

Additional Variant Information for MIR574 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR574

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR574 Gene

Disorders for MIR574 Gene

MalaCards: The human disease database

(44) MalaCards diseases for MIR574 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
spinal chordoma
  • chordoma of spine
fragile x-associated tremor/ataxia syndrome
  • fxtas syndrome
maxillary sinus cancer
  • malignant neoplasm of antrum
cerebral arterial disease
  • cerebral arterial diseases
chordoma
  • chordoma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR574

genes like me logo Genes that share disorders with MIR574: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR574 Gene

Publications for MIR574 Gene

  1. MiR-574-5p promotes the differentiation of human cardiac fibroblasts via regulating ARID3A. (PMID: 31672272) Cui J … Xue S (Biochemical and biophysical research communications 2020) 3
  2. miRNA-574-5p downregulates ZNF70 and influences the progression of human esophageal squamous cell carcinoma through reactive oxygen species generation and MAPK pathway activation. (PMID: 32053575) Han GL … Jiang T (Anti-cancer drugs 2020) 3
  3. MicroRNA-574-5p in gastric cancer cells promotes angiogenesis by targeting protein tyrosine phosphatase non-receptor type 3 (PTPN3). (PMID: 31972307) Zhang S … Yang Q (Gene 2020) 3
  4. PSMB8-AS1 activated by ELK1 promotes cell proliferation in glioma via regulating miR-574-5p/RAB10. (PMID: 31812014) Shen G … Xu F (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020) 3
  5. Long noncoding RNA LINC00052 inhibits colorectal cancer metastasis by sponging microRNA-574-5p to modulate CALCOCO1 expression. (PMID: 31104316) Yu G … Tang H (Journal of cellular biochemistry 2019) 3

Products for MIR574 Gene

Sources for MIR574 Gene