microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR5739 Gene

Subcategory (RNA class) for MIR5739 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR5739 Gene

  • MicroRNA 5739 2 3 5
  • Hsa-Mir-5739 2 3
  • MIR5739 2 5
  • MicroRNA Mir-5739 3
  • MIMAT0023116 50
  • MI0019412 50

External Ids for MIR5739 Gene

Previous GeneCards Identifiers for MIR5739 Gene

  • GC22U901038

Summaries for MIR5739 Gene

Entrez Gene Summary for MIR5739 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5739 Gene

MIR5739 (MicroRNA 5739) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR5739 include Adhesions Of Uterus.

Additional gene information for MIR5739 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR5739 Gene

Genomics for MIR5739 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR5739 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J028441 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas 0.4 -17.2 -17206 2.7 CTCF PRDM10 REST IKZF1 PRDM1 ZNF143 ZIC2 RBFOX2 POLR2A RXRB CHEK2 TTC28-AS1 TTC28 HE856189 MIR5739 PITPNB
GH22J028438 Enhancer 0.8 Ensembl 0.4 -21.3 -21268 0.8 ZNF629 PATZ1 ZBTB44 FOXA1 ZNF639 ZXDB ZEB1 TSHZ1 ZSCAN5C FOXA2 EWSR1 TTC28 TTC28-AS1 ENSG00000272858 HE856189 MIR5739 PITPNB
GH22J028448 Enhancer 0.6 Ensembl 0.4 -10.7 -10668 1.2 NR2C1 NR2C2 NR2F1 TAL1 NR2F6 DPF2 TCF12 CBFA2T2 CBFA2T3 ARID1B TTC28 MIR5739 HE856189 PITPNB
GH22J028435 Enhancer 0.6 Ensembl 0.4 -24.0 -23968 1.4 FOXA1 SP1 FOXA2 ZNF316 OSR2 MAFF ATF3 YY1 MAFK JUND EWSR1 ENSG00000272858 HE856189 MIR5739 TTC28 PITPNB
GH22J028464 Enhancer 0.3 Ensembl 0.7 +4.3 4332 0.4 ZNF652 TTC28 MIR5739 piR-61514-108 PITPNB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR5739 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR5739 Gene

Genomic Locations for MIR5739 Gene
chr22:28,459,869-28,459,948
(GRCh38/hg38)
Size:
80 bases
Orientation:
Plus strand

Genomic View for MIR5739 Gene

Genes around MIR5739 on UCSC Golden Path with GeneCards custom track
MIR5739 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR5739 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5739 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5739 Gene

Proteins for MIR5739 Gene

Post-translational modifications for MIR5739 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR5739 Gene

Domains & Families for MIR5739 Gene

Gene Families for MIR5739 Gene

HGNC:
genes like me logo Genes that share domains with MIR5739: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR5739 Gene

Function for MIR5739 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5739 Gene

Localization for MIR5739 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR5739 Gene

Pathways & Interactions for MIR5739 Gene

PathCards logo

SuperPathways for MIR5739 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR5739 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR5739 Gene

Drugs & Compounds for MIR5739 Gene

No Compound Related Data Available

Transcripts for MIR5739 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR5739 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075C41D_9606 precursor_RNA 80 4

HGNC: 49977,

RefSeq: NR_106713,

Ensembl: ENST00000619803 (view in UCSC) ,

miRBase: MI0019412,

URS0000759A14_9606 miRNA 20 2

RefSeq: NR_106713,

miRBase: MIMAT0023116,

MIR5739 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5739 Gene

No ASD Table

Relevant External Links for MIR5739 Gene

GeneLoc Exon Structure for
MIR5739

No data available for mRNA/cDNA for MIR5739 Gene

Expression for MIR5739 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR5739 Gene

Orthologs for MIR5739 Gene

Evolution for MIR5739 Gene

ENSEMBL:
Gene Tree for MIR5739 (if available)
TreeFam:
Gene Tree for MIR5739 (if available)

No data available for Orthologs for MIR5739 Gene

Paralogs for MIR5739 Gene

No data available for Paralogs for MIR5739 Gene

Variants for MIR5739 Gene

Additional dbSNP identifiers (rs#s) for MIR5739 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR5739 Gene

Variant ID Type Subtype PubMed ID
nsv588880 CNV loss 21841781

Additional Variant Information for MIR5739 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5739

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR5739 Gene

Disorders for MIR5739 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR5739 Gene - From: DISEASES

Disorder Aliases PubMed IDs
adhesions of uterus
  • band of uterus
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR5739

genes like me logo Genes that share disorders with MIR5739: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR5739 Gene

Publications for MIR5739 Gene

  1. The hsa-miR-5739 modulates the endoglin network in endothelial cells derived from human embryonic stem cells. (PMID: 22020071) Yoo JK … Kim JK (Biochemical and biophysical research communications 2011) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR5739 Gene

Sources for MIR5739 Gene