Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR5739 Gene

Subcategory (RNA class) for MIR5739 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR5739 Gene

  • MicroRNA 5739 2 3 5
  • MicroRNA Mir-5739 3
  • Hsa-Mir-5739 3

External Ids for MIR5739 Gene

Previous GeneCards Identifiers for MIR5739 Gene

  • GC22U901038

Summaries for MIR5739 Gene

Entrez Gene Summary for MIR5739 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5739 Gene

MIR5739 (MicroRNA 5739) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR5739 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR5739 Gene

Genomics for MIR5739 Gene

GeneHancer (GH) Regulatory Elements for MIR5739 Gene

Promoters and enhancers for MIR5739 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J028441 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE 0.4 -17.4 -17368 3 ZNF652 SP1 ZFX CTCF MNT ZNF148 GTF2F1 ZNF384 MAFK PRDM1 CHEK2 TTC28-AS1 TTC28 MIR5739 ENSG00000199797
GH22J028396 Enhancer 1.3 FANTOM5 Ensembl ENCODE 0.2 -63.4 -63368 2.2 CBFA2T2 SP1 PRDM1 SMARCA4 RXRA CEBPA PKNOX1 LEF1 HDAC1 SOX13 TTC28 PITPNB MIR5739 ENSG00000199797
GH22J028424 Enhancer 0.8 ENCODE 0.3 -35.0 -34961 0.2 CEBPG RERE PPARG HMG20B SOX13 CEBPA GATAD2A RXRB REST CTBP1 MIR5739 ENSG00000199797 TTC28
GH22J028448 Enhancer 0.6 Ensembl 0.4 -11.0 -10968 1.4 CBFA2T2 SMARCA4 NR2C1 NR2C2 NCOR1 DPF2 TCF12 TAL1 CBFA2T3 TTC28 MIR5739 ENSG00000199797
GH22J028480 Enhancer 0.5 Ensembl 0.3 +20.7 20731 1.2 PKNOX1 POLR2A ZNF629 PRDM6 TTC28 MIR5739 LOC101929594
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR5739 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR5739 Gene

Genomic Locations for MIR5739 Gene
chr22:28,459,869-28,459,948
(GRCh38/hg38)
Size:
80 bases
Orientation:
Plus strand

Genomic View for MIR5739 Gene

Genes around MIR5739 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR5739 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5739 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5739 Gene

Proteins for MIR5739 Gene

Post-translational modifications for MIR5739 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR5739 Gene

Domains & Families for MIR5739 Gene

Gene Families for MIR5739 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR5739: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR5739 Gene

Function for MIR5739 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5739 Gene

Localization for MIR5739 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR5739 Gene

Pathways & Interactions for MIR5739 Gene

PathCards logo

SuperPathways for MIR5739 Gene

No Data Available

Interacting Proteins for MIR5739 Gene

Gene Ontology (GO) - Biological Process for MIR5739 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR5739 Gene

Drugs & Compounds for MIR5739 Gene

No Compound Related Data Available

Transcripts for MIR5739 Gene

mRNA/cDNA for MIR5739 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5739 Gene

No ASD Table

Relevant External Links for MIR5739 Gene

GeneLoc Exon Structure for
MIR5739
ECgene alternative splicing isoforms for
MIR5739

Expression for MIR5739 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR5739 Gene:

MIR5739
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR5739 Gene

Orthologs for MIR5739 Gene

Evolution for MIR5739 Gene

ENSEMBL:
Gene Tree for MIR5739 (if available)
TreeFam:
Gene Tree for MIR5739 (if available)

No data available for Orthologs for MIR5739 Gene

Paralogs for MIR5739 Gene

No data available for Paralogs for MIR5739 Gene

Variants for MIR5739 Gene

Sequence variations from dbSNP and Humsavar for MIR5739 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000126014 -- 28,459,539(+) C/G/T upstream_transcript_variant
rs1000216554 -- 28,459,169(+) G/A upstream_transcript_variant
rs1000457875 -- 28,457,963(+) G/A upstream_transcript_variant
rs1003239598 -- 28,460,353(+) T/A/C downstream_transcript_variant
rs1006020590 -- 28,458,205(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR5739 Gene

Variant ID Type Subtype PubMed ID
nsv588880 CNV loss 21841781

Additional Variant Information for MIR5739 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5739

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR5739 Gene

Disorders for MIR5739 Gene

Additional Disease Information for MIR5739

No disorders were found for MIR5739 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5739 Gene

Publications for MIR5739 Gene

  1. The hsa-miR-5739 modulates the endoglin network in endothelial cells derived from human embryonic stem cells. (PMID: 22020071) Yoo JK … Kim JK (Biochemical and biophysical research communications 2011) 3 58
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR5739 Gene

Sources for MIR5739 Gene

Content
Loading form....