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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR572 (MicroRNA 572) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR572 include Squamous Cell Carcinoma, Head And Neck and Ovarian Cancer.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH04J011368 | Promoter | 0.7 | Ensembl CraniofacialAtlas | 600.7 | +0.4 | 373 | 1.6 | MIR572 RNPS1P1 piR-39858-468 piR-41525-509 HS3ST1 lnc-DRD5-23-001 CLNK | ||
GH04J011341 | Enhancer | 0.4 | Ensembl | 12.8 | -26.9 | -26926 | 0.2 | TBX21 ATF7 MTA2 | RNPS1P1 MIR572 piR-38372-005 lnc-DRD5-8 HS3ST1 lnc-DRD5-23-001 CLNK | |
GH04J011343 | Enhancer | 0.3 | Ensembl | 12.8 | -25.3 | -25326 | 1 | SMARCA4 | RNPS1P1 MIR572 lnc-DRD5-8 piR-38372-005 HS3ST1 lnc-DRD5-23-001 CLNK | |
GH04J011348 | Enhancer | 0.2 | Ensembl | 13 | -20.0 | -20026 | 0.8 | RNPS1P1 MIR572 HS3ST1 piR-38372-005 lnc-DRD5-8 lnc-DRD5-23-001 CLNK |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 20190813 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075C548_9606 | precursor_RNA | 95 | 4 |
HGNC: 32828, RefSeq: NR_030298, Ensembl: ENST00000384983 (view in UCSC) , miRBase: MI0003579, |
URS000075CEB8_9606 | miRNA | 20 | 4 |
RefSeq: NR_030298, LncBase: hsa-miR-572, miRBase: MIMAT0003237, TarBase: hsa-miR-572, |
URS000067E593_9606 | precursor_RNA | 56 | 1 |
Rfam: RF01020, |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1000613 | CNV | loss | 25217958 |
nsv1010891 | CNV | loss | 25217958 |
Disorder | Aliases | PubMed IDs |
---|---|---|
squamous cell carcinoma, head and neck |
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ovarian cancer |
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