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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR5702 (MicroRNA 5702) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH02J226655 | Enhancer | 1.5 | FANTOM5 Ensembl ENCODE dbSUPER | 600.7 | -0.4 | -356 | 7.7 | GATAD2A ATF7 PRDM10 REST ZNF629 SOX13 ZNF692 RCOR2 JUND GABPA | MIR5702 IRS1 lnc-IRS1-7 | |
GH02J226649 | Enhancer | 1.5 | FANTOM5 Ensembl ENCODE dbSUPER | 0.4 | +7.0 | 6960 | 5.5 | GATAD2A PRDM10 ZNF629 TFE3 SOX13 NFKBIZ RCOR2 ZNF7 ZIC2 RXRB | IRS1 piR-50129-134 MIR5702 lnc-IRS1-7 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075E543_9606 | precursor_RNA | 84 | 4 |
HGNC: 43503, RefSeq: NR_049887, Ensembl: ENST00000582265 (view in UCSC) , miRBase: MI0019309, |
URS000075EAC4_9606 | miRNA | 22 | 2 |
RefSeq: NR_049887, miRBase: MIMAT0022495, |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1011562 | CNV | loss | 25217958 |
nsv584594 | CNV | gain | 21841781 |
No disorders were found for MIR5702 Gene.