Free for academic non-profit institutions. Other users need a Commercial license
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR5685 (MicroRNA 5685) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH06J053278 | Enhancer | 0.3 | dbSUPER | 600.7 | +1.6 | 1585 | 0.7 | SCRT2 SCRT1 | MIR5685 RF00017-5602 GCM1 lnc-GCM1-4 ELOVL5 MN298114-205 | |
GH06J053275 | Enhancer | 0.2 | dbSUPER | 600.7 | -0.4 | -424 | 1.2 | MIR5685 ELOVL5 GCM1 lnc-GCM1-4 MN298114-205 | ||
GH06J053279 | Enhancer | 1 | Ensembl ENCODE dbSUPER | 0.4 | +6.1 | 6108 | 6.2 | TCF12 IKZF2 EED DPF2 RELB RUNX3 IKZF1 NR2F1 GATA3 JUNB | ELOVL5 RPL31P28 RF00017-5602 MIR5685 GCM1 lnc-GCM1-4 MN298114-205 | |
GH06J053271 | Enhancer | 0.4 | dbSUPER | 0.7 | -4.0 | -4003 | 3.1 | SCRT2 CTCF RAD21 HLF | ELOVL5 MIR5685 GCM1 MN298114-205 | |
GH06J053263 | Enhancer | 0.5 | Ensembl ENCODE dbSUPER | 0.4 | -12.2 | -12192 | 2.8 | GCM1 ELOVL5 MIR5685 MN298114-205 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075D3B4_9606 | precursor_RNA | 79 | 4 |
HGNC: 43543, RefSeq: NR_049866, Ensembl: ENST00000579080 (view in UCSC) , miRBase: MI0019287, |
URS000075B307_9606 | miRNA | 22 | 2 |
RefSeq: NR_049866, miRBase: MIMAT0022475, |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2763940 | CNV | gain+loss | 21179565 |
nsv1033994 | CNV | gain | 25217958 |
No disorders were found for MIR5685 Gene.