Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR566 Gene

Subcategory (RNA class) for MIR566 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR566 Gene

  • MicroRNA 566 2 3 5
  • Hsa-Mir-566 3
  • MIRN566 3

External Ids for MIR566 Gene

ORGUL Members for MIR566 Gene

Previous HGNC Symbols for MIR566 Gene

  • MIRN566

Previous GeneCards Identifiers for MIR566 Gene

  • GC03P050186
  • GC03P050210

Summaries for MIR566 Gene

Entrez Gene Summary for MIR566 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR566 Gene

MIR566 (MicroRNA 566) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR566 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR566 Gene

Genomics for MIR566 Gene

GeneHancer (GH) Regulatory Elements for MIR566 Gene

Promoters and enhancers for MIR566 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I050173 Enhancer 0.6 dbSUPER 550.8 +0.7 667 1.3 CTCF SCRT1 ZFHX2 EGR1 SCRT2 MAX ZBTB33 MYC GC03P050173 MIR566 CYB561D2 GC03P050187 GC03P050190 SEMA3F
GH03I050176 Enhancer 0.6 dbSUPER 0.8 +3.7 3679 1.4 NFIA RXRA MAX RAD21 NR2F2 YY1 HNF4A PRDM10 MIR566 GC03P050187 GC03P050190 SEMA3F
GH03I050179 Enhancer 0.7 ENCODE dbSUPER 0.4 +6.7 6667 0.8 MEIS2 STAT1 IKZF1 HMBOX1 PRDM10 PRDM1 RBM6 HYAL3 SEMA3F SEMA3F-AS1 GNAI2 LSMEM2 IFRD2 SEMA3B SEMA3B-AS1 GC03P050187
GH03I050182 Enhancer 0.6 dbSUPER 0.4 +10.9 10858 3.7 ESRRA ZNF687 PKNOX1 RXRA DPF2 ZNF217 CTBP1 GATA3 RCOR1 ZBTB33 SEMA3F SEMA3F-AS1 GNAI2 SEMA3B SEMA3B-AS1 LSMEM2 IFRD2 HYAL3 RBM6 HYAL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR566 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR566 Gene

Genomic Locations for MIR566 Gene
chr3:50,173,326-50,173,419
(GRCh38/hg38)
Size:
94 bases
Orientation:
Plus strand
chr3:50,210,759-50,210,852
(GRCh37/hg19)

Genomic View for MIR566 Gene

Genes around MIR566 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR566 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR566 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR566 Gene

Proteins for MIR566 Gene

Post-translational modifications for MIR566 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR566 Gene

Domains & Families for MIR566 Gene

Gene Families for MIR566 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR566: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR566 Gene

Function for MIR566 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR566 Gene

Localization for MIR566 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR566 Gene

Pathways & Interactions for MIR566 Gene

SuperPathways for MIR566 Gene

No Data Available

Interacting Proteins for MIR566 Gene

Gene Ontology (GO) - Biological Process for MIR566 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR566 Gene

Drugs & Compounds for MIR566 Gene

No Compound Related Data Available

Transcripts for MIR566 Gene

mRNA/cDNA for MIR566 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR566 Gene

No ASD Table

Relevant External Links for MIR566 Gene

GeneLoc Exon Structure for
MIR566
ECgene alternative splicing isoforms for
MIR566

Expression for MIR566 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR566 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR566 Gene:

MIR566
genes like me logo Genes that share expression patterns with MIR566: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR566 Gene

Orthologs for MIR566 Gene

Evolution for MIR566 Gene

ENSEMBL:
Gene Tree for MIR566 (if available)
TreeFam:
Gene Tree for MIR566 (if available)

No data available for Orthologs for MIR566 Gene

Paralogs for MIR566 Gene

No data available for Paralogs for MIR566 Gene

Variants for MIR566 Gene

Sequence variations from dbSNP and Humsavar for MIR566 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000195766 -- 50,171,598(+) C/T upstream_transcript_variant
rs1000694880 -- 50,171,782(+) C/T upstream_transcript_variant
rs1001607241 -- 50,172,943(+) G/T upstream_transcript_variant
rs1002682844 -- 50,172,248(+) C/T upstream_transcript_variant
rs1003123637 -- 50,171,862(+) GG/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR566 Gene

Variant ID Type Subtype PubMed ID
nsv954855 CNV deletion 24416366
nsv834692 CNV loss 17160897
nsv834690 CNV loss 17160897
nsv523662 CNV loss 19592680
nsv523560 CNV loss 19592680
nsv515986 CNV loss 19592680
nsv470561 CNV loss 18288195
esv2759148 CNV loss 17122850
dgv8316n54 CNV loss 21841781
dgv602n27 CNV loss 19166990

Additional Variant Information for MIR566 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR566

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR566 Gene

Disorders for MIR566 Gene

Additional Disease Information for MIR566

No disorders were found for MIR566 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR566 Gene

Publications for MIR566 Gene

  1. MicroRNA‑566 modulates vascular endothelial growth factor by targeting Von Hippel‑Landau in human glioblastoma in vitro and in vivo. (PMID: 26572705) Xiao B … Zhu X (Molecular medicine reports 2016) 58
  2. MicroRNA-566 activates EGFR signaling and its inhibition sensitizes glioblastoma cells to nimotuzumab. (PMID: 24650032) Zhang KL … Kang CS (Molecular cancer 2014) 58
  3. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 58
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 58

Products for MIR566 Gene

Sources for MIR566 Gene

Content
Loading form....