microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR562 Gene

Subcategory (RNA class) for MIR562 Gene

miRNA

Number of RNA Genes sources:

3 / 17

Aliases for MIR562 Gene

  • MicroRNA 562 2 3 5
  • Hsa-Mir-562 2 3
  • MIR562 2 5
  • MIMAT0003226 50
  • Hsa-MiR-562 173
  • MI0003568 50
  • MIRN562 3
  • RF00998 168

External Ids for MIR562 Gene

Previous HGNC Symbols for MIR562 Gene

  • MIRN562

Previous GeneCards Identifiers for MIR562 Gene

  • GC02P232746
  • GC02P233037

Summaries for MIR562 Gene

Entrez Gene Summary for MIR562 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR562 Gene

MIR562 (MicroRNA 562) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR562 include Perlman Syndrome and Wilms Tumor 1.

Rfam classification for MIR562 Gene

Additional gene information for MIR562 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR562 Gene

Genomics for MIR562 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR562 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J232170 Enhancer 0.3 Ensembl 600.7 -1.7 -1652 0.4 ESR1 MIR562 piR-57394-110 ALPP DIS3L2
GH02J232171 Enhancer 0.2 Ensembl 600.7 -1.1 -1052 0.4 MIR562 piR-57394-110 ALPP DIS3L2
GH02J232135 Enhancer 0.8 Ensembl ENCODE 11.6 -35.0 -34953 5.8 GATAD2A RXRB CEBPB ZNF316 FOXA2 MAFF MAFK MAFG MIER3 SPI1 NPPC MIR562 MIR1471 ENSG00000251485 piR-30240 piR-57394-110 DIS3L2 ALPP
GH02J232204 Enhancer 0.7 Ensembl ENCODE 11.5 +31.7 31671 1.4 SOX13 TEAD1 BCL6 HNF4A NFIL3 RXRA DMAP1 SOX5 HLF NR2F6 MIR562 DIS3L2 ENSG00000227033 MIR1471 ENSG00000251485 lnc-ALPP-3 ALPP
GH02J232306 Enhancer 0.7 Ensembl ENCODE dbSUPER 10.6 +136.8 136766 5.6 ZNF143 POLR2A NPPC MIR1471 MIR562 ENSG00000251485 EIF4E2 HSALNG0023022 HSALNG0023023 ALPP DIS3L2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR562 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR562 Gene

Genomic Locations for MIR562 Gene
chr2:232,172,653-232,172,747
(GRCh38/hg38)
Size:
95 bases
Orientation:
Plus strand
chr2:233,037,363-233,037,457
(GRCh37/hg19)
Size:
95 bases
Orientation:
Plus strand

Genomic View for MIR562 Gene

Genes around MIR562 on UCSC Golden Path with GeneCards custom track
MIR562 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR562 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR562 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR562 Gene

Proteins for MIR562 Gene

Post-translational modifications for MIR562 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR562 Gene

Domains & Families for MIR562 Gene

Gene Families for MIR562 Gene

HGNC:
genes like me logo Genes that share domains with MIR562: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR562 Gene

Function for MIR562 Gene

Phenotypes From GWAS Catalog for MIR562 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR562 Gene

Localization for MIR562 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR562 gene
Compartment Confidence
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR562 Gene

Pathways & Interactions for MIR562 Gene

PathCards logo

SuperPathways for MIR562 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR562 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR562: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR562 Gene

Drugs & Compounds for MIR562 Gene

No Compound Related Data Available

Transcripts for MIR562 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR562 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075A7C1_9606 precursor_RNA 95 5

HGNC: 32818,

RefSeq: NR_030288,

Ensembl: ENST00000384894 (view in UCSC) ,

miRBase: MI0003568,

Rfam: RF00998,

URS000075A5E2_9606 miRNA 20 3

RefSeq: NR_030288,

miRBase: MIMAT0003226,

TarBase: hsa-miR-562,

MIR562 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR562 Gene

No ASD Table

Relevant External Links for MIR562 Gene

GeneLoc Exon Structure for
MIR562

No data available for mRNA/cDNA for MIR562 Gene

Expression for MIR562 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR562 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR562

genes like me logo Genes that share expression patterns with MIR562: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR562 Gene

Orthologs for MIR562 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR562 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-562 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-562 31
  • 77 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 68 (a)
ManyToMany
Species where no ortholog for MIR562 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR562 Gene

ENSEMBL:
Gene Tree for MIR562 (if available)
TreeFam:
Gene Tree for MIR562 (if available)

Paralogs for MIR562 Gene

No data available for Paralogs for MIR562 Gene

Variants for MIR562 Gene

Additional dbSNP identifiers (rs#s) for MIR562 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR562 Gene

Variant ID Type Subtype PubMed ID
esv3594640 CNV loss 21293372
nsv3209 CNV deletion 18451855

Additional Variant Information for MIR562 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR562

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR562 Gene

Disorders for MIR562 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR562 Gene - From: DISEASES

Disorder Aliases PubMed IDs
perlman syndrome
  • nephroblastoma
wilms tumor 1
  • wt1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR562

genes like me logo Genes that share disorders with MIR562: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR562 Gene

Publications for MIR562 Gene

  1. Annexin-A1 regulates microRNA-26b* and microRNA-562 to directly target NF-κB and angiogenesis in breast cancer cells. (PMID: 25536365) Anbalagan D … Lim LH (PloS one 2014) 3
  2. Loss of heterozygosity at 2q37 in sporadic Wilms' tumor: putative role for miR-562. (PMID: 19789318) Drake KM … Aldred MA (Clinical cancer research : an official journal of the American Association for Cancer Research 2009) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3
  4. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 3

Products for MIR562 Gene

Sources for MIR562 Gene