microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR5590 Gene

Data sources for MIR5590 Gene:

Subcategory (RNA class) for MIR5590 Gene

miRNA

Aliases for MIR5590 Gene

External Ids for MIR5590 Gene

Previous GeneCards Identifiers for MIR5590 Gene

  • GC02U902464
  • GC02P135619

Summaries for MIR5590 Gene

Entrez Gene Summary for MIR5590 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5590 Gene

MIR5590 (MicroRNA 5590) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR5590 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR5590 Gene

Genomics for MIR5590 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR5590 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J134866 Enhancer 0.7 Ensembl ENCODE 0.4 +9.1 9080 1 CEBPB FOXA2 CTBP1 FOXA1 ATF4 ESRRA EP300 FOS ATF3 ACMSD TMEM163 MIR5590 piR-57134-065 CCNT2 CCNT2-AS1
GH02J134843 Enhancer 0.4 Ensembl 0.4 -14.5 -14519 0.2 CTBP1 HNF4A DPF2 CCNT2 ACMSD piR-56341-121 MIR5590 CCNT2-AS1
GH02J134845 Enhancer 0.4 Ensembl 0.4 -11.8 -11819 0.8 HNF4A SP1 ATF3 CCNT2 TMEM163 ACMSD piR-56341-121 MIR5590 CCNT2-AS1
GH02J134844 Enhancer 0.2 Ensembl 0.4 -13.9 -13919 0.2 CCNT2 piR-56341-121 ACMSD MIR5590 CCNT2-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR5590 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR5590 Gene

Latest Assembly
chr2:134,857,820-134,857,873
(GRCh38/hg38)
Size:
54 bases
Orientation:
Plus strand

Previous Assembly
chr2:135,615,390-135,615,443
(GRCh37/hg19 by Entrez Gene)
Size:
54 bases
Orientation:
Plus strand

chr2:135,615,390-135,615,443
(GRCh37/hg19 by Ensembl)
Size:
54 bases
Orientation:
Plus strand

Genomic View for MIR5590 Gene

Genes around MIR5590 on UCSC Golden Path with GeneCards custom track
MIR5590 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR5590 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5590 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5590 Gene

Proteins for MIR5590 Gene

Post-translational modifications for MIR5590 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR5590 Gene

Domains & Families for MIR5590 Gene

Gene Families for MIR5590 Gene

HGNC:
genes like me logo Genes that share domains with MIR5590: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR5590 Gene

Function for MIR5590 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5590 Gene

Localization for MIR5590 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR5590 Gene

Pathways & Interactions for MIR5590 Gene

PathCards logo

SuperPathways for MIR5590 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR5590 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR5590 Gene

Drugs & Compounds for MIR5590 Gene

No Compound Related Data Available

Transcripts for MIR5590 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR5590 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000759C72_9606 precursor_RNA 54 3

RefSeq: NR_049856,

Ensembl: ENST00000577826 (view in UCSC) ,

miRBase: MI0019150,

URS000075D290_9606 miRNA 21 2

RefSeq: NR_049856,

miRBase: MIMAT0022300,

URS000075E858_9606 miRNA 21 2

RefSeq: NR_049856,

miRBase: MIMAT0022299,

MIR5590 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5590 Gene

No ASD Table

Relevant External Links for MIR5590 Gene

GeneLoc Exon Structure for
MIR5590

No data available for mRNA/cDNA for MIR5590 Gene

Expression for MIR5590 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR5590 Gene

Orthologs for MIR5590 Gene

Evolution for MIR5590 Gene

ENSEMBL:
Gene Tree for MIR5590 (if available)
TreeFam:
Gene Tree for MIR5590 (if available)

No data available for Orthologs for MIR5590 Gene

Paralogs for MIR5590 Gene

No data available for Paralogs for MIR5590 Gene

Variants for MIR5590 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR5590 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for MIR5590 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5590

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR5590 Gene

Disorders for MIR5590 Gene

Additional Disease Information for MIR5590

No disorders were found for MIR5590 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5590 Gene

Publications for MIR5590 Gene

  1. Regulatory effect of hsa-miR-5590-3P on TGFβ signaling through targeting of TGFβ-R1, TGFβ-R2, SMAD3 and SMAD4 transcripts. (PMID: 30391930) Abedini Bakhshmand E … Soltani BM (Biological chemistry 2019) 3
  2. A SOX9-AS1/miR-5590-3p/SOX9 positive feedback loop drives tumor growth and metastasis in hepatocellular carcinoma through the Wnt/β-catenin pathway. (PMID: 31402556) Zhang W … Xu Z (Molecular oncology 2019) 3
  3. miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. (PMID: 21911355) Friedländer MR … Rajewsky N (Nucleic acids research 2012) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR5590 Gene

Sources for MIR5590 Gene