microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR5589 Gene

Subcategory (RNA class) for MIR5589 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR5589 Gene

  • MicroRNA 5589 2 3 5
  • Hsa-Mir-5589 2 3
  • MIR5589 2 5
  • MIMAT0022297 50
  • MIMAT0022298 50
  • MI0019148 50

External Ids for MIR5589 Gene

Previous GeneCards Identifiers for MIR5589 Gene

  • GC19U901601
  • GC19P010154
  • GC19P010155

Summaries for MIR5589 Gene

Entrez Gene Summary for MIR5589 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5589 Gene

MIR5589 (MicroRNA 5589) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR5589 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR5589 Gene

Genomics for MIR5589 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR5589 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J010036 Enhancer 0.9 Ensembl ENCODE 600.7 -1.4 -1351 0.8 GATAD2A ATF7 REST SP1 CEBPA SOX13 CEBPB FOXA2 ATF3 YY1 C3P1 MIR5589 lnc-RDH8-1 piR-57133-301 RDH8 SHFL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR5589 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR5589 Gene

Genomic Locations for MIR5589 Gene
chr19:10,038,354-10,038,413
(GRCh38/hg38)
Size:
60 bases
Orientation:
Plus strand
chr19:10,149,030-10,149,089
(GRCh37/hg19)
Size:
60 bases
Orientation:
Plus strand

Genomic View for MIR5589 Gene

Genes around MIR5589 on UCSC Golden Path with GeneCards custom track
MIR5589 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR5589 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5589 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5589 Gene

Proteins for MIR5589 Gene

Post-translational modifications for MIR5589 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR5589 Gene

Domains & Families for MIR5589 Gene

Gene Families for MIR5589 Gene

HGNC:
genes like me logo Genes that share domains with MIR5589: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR5589 Gene

Function for MIR5589 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5589 Gene

Localization for MIR5589 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR5589 Gene

Pathways & Interactions for MIR5589 Gene

PathCards logo

SuperPathways for MIR5589 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR5589 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR5589 Gene

Drugs & Compounds for MIR5589 Gene

No Compound Related Data Available

Transcripts for MIR5589 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR5589 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075D4F5_9606 precursor_RNA 60 4

HGNC: 43514,

RefSeq: NR_049855,

Ensembl: ENST00000579442 (view in UCSC) ,

miRBase: MI0019148,

URS000075C293_9606 miRNA 23 2

RefSeq: NR_049855,

miRBase: MIMAT0022298,

URS0000759BC8_9606 miRNA 21 2

RefSeq: NR_049855,

miRBase: MIMAT0022297,

MIR5589 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5589 Gene

No ASD Table

Relevant External Links for MIR5589 Gene

GeneLoc Exon Structure for
MIR5589

No data available for mRNA/cDNA for MIR5589 Gene

Expression for MIR5589 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR5589 Gene

genes like me logo Genes that share expression patterns with MIR5589: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR5589 Gene

Orthologs for MIR5589 Gene

Evolution for MIR5589 Gene

ENSEMBL:
Gene Tree for MIR5589 (if available)
TreeFam:
Gene Tree for MIR5589 (if available)

No data available for Orthologs for MIR5589 Gene

Paralogs for MIR5589 Gene

No data available for Paralogs for MIR5589 Gene

Variants for MIR5589 Gene

Additional dbSNP identifiers (rs#s) for MIR5589 Gene

Additional Variant Information for MIR5589 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5589

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR5589 Gene

Disorders for MIR5589 Gene

Additional Disease Information for MIR5589

No disorders were found for MIR5589 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5589 Gene

Publications for MIR5589 Gene

  1. miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. (PMID: 21911355) Friedländer MR … Rajewsky N (Nucleic acids research 2012) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR5589 Gene

Sources for MIR5589 Gene