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Aliases for MIR5588 Gene

Subcategory (RNA class) for MIR5588 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR5588 Gene

  • MicroRNA 5588 2 3 5
  • Hsa-Mir-5588 3

External Ids for MIR5588 Gene

Previous GeneCards Identifiers for MIR5588 Gene

  • GC03U901831
  • GC03M184974

Summaries for MIR5588 Gene

Entrez Gene Summary for MIR5588 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5588 Gene

MIR5588 (MicroRNA 5588) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR5588 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR5588 Gene

Genomics for MIR5588 Gene

GeneHancer (GH) Regulatory Elements for MIR5588 Gene

Promoters and enhancers for MIR5588 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I185253 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.7 -696 1.4 PKNOX1 ATF1 FOXA2 DMAP1 ZNF48 YY1 POLR2B GLIS2 ATF7 RUNX3 MIR5588 EHHADH VPS8 MAP3K13
GH03I185250 Enhancer 0.8 ENCODE 0.8 +2.4 2438 1.5 ELF3 FOXA2 RARA YY1 CREM MIXL1 RXRA REST PPARG NFIL3 VPS8 MAP3K13 EIF2S2P2 MIR5588 EHHADH
GH03I185246 Promoter 0.7 EPDnew 0.4 +6.7 6694 0.1 ATF4 L3MBTL2 EIF2S2P2 GC03M185246 EHHADH MIR5588
GH03I185280 Enhancer 0.8 ENCODE 0.3 -27.7 -27656 0.2 HDAC1 ELF3 ATF1 ARID4B RAD21 ZBTB40 RFX5 ZNF143 ETV6 ATF7 EHHADH MAGEF1 MIR5588
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR5588 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR5588 Gene

Genomic Locations for MIR5588 Gene
chr3:185,253,210-185,253,272
(GRCh38/hg38)
Size:
63 bases
Orientation:
Minus strand
chr3:184,970,998-184,971,060
(GRCh37/hg19)

Genomic View for MIR5588 Gene

Genes around MIR5588 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR5588 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5588 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5588 Gene

ORGUL Member Location for MIR5588 Gene

ORGUL Member Location for MIR5588 gene

Proteins for MIR5588 Gene

Post-translational modifications for MIR5588 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR5588 Gene

Domains & Families for MIR5588 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR5588 Gene

Function for MIR5588 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5588 Gene

Localization for MIR5588 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR5588 Gene

Pathways & Interactions for MIR5588 Gene

SuperPathways for MIR5588 Gene

No Data Available

Interacting Proteins for MIR5588 Gene

Gene Ontology (GO) - Biological Process for MIR5588 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR5588 Gene

Drugs & Compounds for MIR5588 Gene

No Compound Related Data Available

Transcripts for MIR5588 Gene

mRNA/cDNA for MIR5588 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5588 Gene

No ASD Table

Relevant External Links for MIR5588 Gene

GeneLoc Exon Structure for
MIR5588
ECgene alternative splicing isoforms for
MIR5588

Expression for MIR5588 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR5588 Gene:

MIR5588
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR5588 Gene

Orthologs for MIR5588 Gene

Evolution for MIR5588 Gene

ENSEMBL:
Gene Tree for MIR5588 (if available)
TreeFam:
Gene Tree for MIR5588 (if available)

No data available for Orthologs for MIR5588 Gene

Paralogs for MIR5588 Gene

No data available for Paralogs for MIR5588 Gene

Variants for MIR5588 Gene

Sequence variations from dbSNP and Humsavar for MIR5588 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs398124646 pathogenic, Fanconi renotubular syndrome 3 185,254,016(-) C/T upstream_transcript_variant
rs1000084392 -- 185,254,523(-) A/G upstream_transcript_variant
rs1000533085 -- 185,254,930(-) T/G upstream_transcript_variant
rs1001403516 -- 185,253,841(-) T/A upstream_transcript_variant
rs1003412942 -- 185,254,969(-) C/G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR5588 Gene

Variant ID Type Subtype PubMed ID
dgv5002n100 CNV gain 25217958
nsv829817 CNV gain 17160897

Additional Variant Information for MIR5588 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5588

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR5588 Gene

Disorders for MIR5588 Gene

Additional Disease Information for MIR5588

No disorders were found for MIR5588 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5588 Gene

Publications for MIR5588 Gene

  1. miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. (PMID: 21911355) Friedländer MR … Rajewsky N (Nucleic acids research 2012) 3 58
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR5588 Gene

Sources for MIR5588 Gene

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