microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR5582 Gene

Subcategory (RNA class) for MIR5582 Gene

miRNA

Number of RNA Genes sources:

3 / 17

Aliases for MIR5582 Gene

  • MicroRNA 5582 2 3 5
  • Hsa-MiR-5582-3p 163 173
  • Hsa-Mir-5582 2 3
  • MIR5582 2 5
  • MIMAT0022280 50
  • MIMAT0022279 50
  • MI0019138 50

External Ids for MIR5582 Gene

Previous GeneCards Identifiers for MIR5582 Gene

  • GC11U901903
  • GC11M048087
  • GC11M048814
  • GC11M049929
  • GC11M047085
  • GC11M047972
  • GC11M055889
  • GC11M056134
  • GC11M056413
  • GC11M059998
  • GC11M050863
  • GC11M051651
  • GC11M052313
  • GC11M052974
  • GC11M053642
  • GC11M054307
  • GC11M054973
  • GC11M055694

Summaries for MIR5582 Gene

Entrez Gene Summary for MIR5582 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5582 Gene

MIR5582 (MicroRNA 5582) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR5582 include Post-Cardiac Arrest Syndrome.

Additional gene information for MIR5582 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR5582 Gene

Genomics for MIR5582 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR5582 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J046755 Enhancer 0.4 ENCODE 0.7 -2.4 -2404 0.2 FOXA2 THRB JUND ENSG00000252427 MIR5582 F2 CKAP5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR5582 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR5582 Gene

Genomic Locations for MIR5582 Gene
chr11:46,753,125-46,753,192
(GRCh38/hg38)
Size:
68 bases
Orientation:
Minus strand
chr11:46,774,675-46,774,742
(GRCh37/hg19)
Size:
68 bases
Orientation:
Minus strand

Genomic View for MIR5582 Gene

Genes around MIR5582 on UCSC Golden Path with GeneCards custom track
MIR5582 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR5582 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5582 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5582 Gene

Proteins for MIR5582 Gene

Post-translational modifications for MIR5582 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR5582 Gene

Domains & Families for MIR5582 Gene

Gene Families for MIR5582 Gene

HGNC:
genes like me logo Genes that share domains with MIR5582: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR5582 Gene

Function for MIR5582 Gene

Phenotypes From GWAS Catalog for MIR5582 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5582 Gene

Localization for MIR5582 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR5582 Gene

Pathways & Interactions for MIR5582 Gene

PathCards logo

SuperPathways for MIR5582 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR5582 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR5582 Gene

Drugs & Compounds for MIR5582 Gene

No Compound Related Data Available

Transcripts for MIR5582 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR5582 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075AF3A_9606 precursor_RNA 68 4

HGNC: 43461,

RefSeq: NR_049846,

Ensembl: ENST00000579697 (view in UCSC) ,

miRBase: MI0019138,

URS000075D126_9606 miRNA 22 4

RefSeq: NR_049846,

LncBase: hsa-miR-5582-3p,

miRBase: MIMAT0022280,

TarBase: hsa-miR-5582-3p,

URS000075A76C_9606 miRNA 22 2

RefSeq: NR_049846,

miRBase: MIMAT0022279,

MIR5582 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5582 Gene

No ASD Table

Relevant External Links for MIR5582 Gene

GeneLoc Exon Structure for
MIR5582

No data available for mRNA/cDNA for MIR5582 Gene

Expression for MIR5582 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR5582 Gene

genes like me logo Genes that share expression patterns with MIR5582: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR5582 Gene

Orthologs for MIR5582 Gene

Evolution for MIR5582 Gene

ENSEMBL:
Gene Tree for MIR5582 (if available)
TreeFam:
Gene Tree for MIR5582 (if available)

No data available for Orthologs for MIR5582 Gene

Paralogs for MIR5582 Gene

No data available for Paralogs for MIR5582 Gene

Variants for MIR5582 Gene

Additional dbSNP identifiers (rs#s) for MIR5582 Gene

Additional Variant Information for MIR5582 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5582

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR5582 Gene

Disorders for MIR5582 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR5582 Gene - From: DISEASES

Disorder Aliases PubMed IDs
post-cardiac arrest syndrome
  • post cardiac syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR5582

genes like me logo Genes that share disorders with MIR5582: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR5582 Gene

Publications for MIR5582 Gene

  1. Long non-coding RNA LUCAT1/miR-5582-3p/TCF7L2 axis regulates breast cancer stemness via Wnt/β-catenin pathway. (PMID: 31300015) Zheng A … Jin F (Journal of experimental & clinical cancer research : CR 2019) 3
  2. Three miRNAs cooperate with host genes involved in human cardiovascular disease. (PMID: 31464655) Zhu Y … Sun H (Human genomics 2019) 3
  3. Hsa-miR-5582-3P regulatory effect on TGFβ signaling through targeting of TGFβ-R1, TGFβ-R2, SMAD3, and SMAD4 transcripts. (PMID: 30129155) Abedini Bakhshmand E … Mowla SJ (Journal of cellular biochemistry 2018) 3
  4. Novel miR-5582-5p functions as a tumor suppressor by inducing apoptosis and cell cycle arrest in cancer cells through direct targeting of GAB1, SHC1, and CDK2. (PMID: 27475256) An HJ … Han YH (Biochimica et biophysica acta 2016) 3
  5. miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. (PMID: 21911355) Friedländer MR … Rajewsky N (Nucleic acids research 2012) 3

Products for MIR5582 Gene

Sources for MIR5582 Gene