microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR5581 Gene

Subcategory (RNA class) for MIR5581 Gene

miRNA

Number of RNA Genes sources:

3 / 14

Aliases for MIR5581 Gene

  • MicroRNA 5581 2 3 5
  • Hsa-MiR-5581-3p 166 177
  • Hsa-MiR-5581-5p 166 177
  • Hsa-Mir-5581 3
  • MIMAT0022275 51
  • MIMAT0022276 51
  • MI0019136 51
  • MIR5581 2

External Ids for MIR5581 Gene

Previous GeneCards Identifiers for MIR5581 Gene

  • GC01U903354
  • GC01M037969

Summaries for MIR5581 Gene

Entrez Gene Summary for MIR5581 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5581 Gene

MIR5581 (MicroRNA 5581) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR5581 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR5581 Gene

Genomics for MIR5581 Gene

GeneHancer (GH) Regulatory Elements for MIR5581 Gene

Promoters and enhancers for MIR5581 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J037496 Enhancer 1.3 UCNEbase Ensembl ENCODE dbSUPER 0.7 +2.7 2694 3.8 TCF12 ZNF10 MXI1 NFIC FOSL2 ATF3 NR3C1 JUND ZBTB48 RFX5 DNALI1 LINC01137 GNL2 MEAF6 ZC3H12A ENSG00000237749 SNIP1 C1orf109 CDCA8 EPHA10
GH01J037495 Enhancer 0.8 Ensembl 0.4 +5.1 5124 0.9 ZNF217 ZNF639 ZNF623 ZNF510 KLF7 CUX1 EP300 ZNF266 MYNN CEBPB piR-45035-006 SF3A3 C1orf109 INPP5B SNIP1 GNL2 FTH1P1 RSPO1 LINC01137 ZC3H12A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR5581 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR5581 Gene

Genomic Locations for MIR5581 Gene
chr1:37,500,935-37,500,994
(GRCh38/hg38)
Size:
60 bases
Orientation:
Minus strand
chr1:37,966,536-37,966,595
(GRCh37/hg19)
Size:
60 bases
Orientation:
Minus strand

Genomic View for MIR5581 Gene

Genes around MIR5581 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR5581 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5581 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5581 Gene

Proteins for MIR5581 Gene

Post-translational modifications for MIR5581 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR5581 Gene

Domains & Families for MIR5581 Gene

Gene Families for MIR5581 Gene

HGNC:
genes like me logo Genes that share domains with MIR5581: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR5581 Gene

Function for MIR5581 Gene

Phenotypes From GWAS Catalog for MIR5581 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5581 Gene

Localization for MIR5581 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR5581 Gene

Pathways & Interactions for MIR5581 Gene

PathCards logo

SuperPathways for MIR5581 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR5581 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR5581 Gene

Drugs & Compounds for MIR5581 Gene

No Compound Related Data Available

Transcripts for MIR5581 Gene

mRNA/cDNA for MIR5581 Gene

3 RNACentral transcripts :
1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
2 LncBase transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5581 Gene

No ASD Table

Relevant External Links for MIR5581 Gene

GeneLoc Exon Structure for
MIR5581

Expression for MIR5581 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR5581 Gene

Orthologs for MIR5581 Gene

Evolution for MIR5581 Gene

ENSEMBL:
Gene Tree for MIR5581 (if available)
TreeFam:
Gene Tree for MIR5581 (if available)

No data available for Orthologs for MIR5581 Gene

Paralogs for MIR5581 Gene

No data available for Paralogs for MIR5581 Gene

Variants for MIR5581 Gene

Additional dbSNP identifiers (rs#s) for MIR5581 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR5581 Gene

Variant ID Type Subtype PubMed ID
nsv519551 CNV gain 19592680
nsv524834 CNV gain 19592680

Additional Variant Information for MIR5581 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5581

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR5581 Gene

Disorders for MIR5581 Gene

Additional Disease Information for MIR5581

No disorders were found for MIR5581 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5581 Gene

Publications for MIR5581 Gene

  1. miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. (PMID: 21911355) Friedländer MR … Rajewsky N (Nucleic acids research 2012) 3 54
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 54

Products for MIR5581 Gene

Sources for MIR5581 Gene