microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR558 Gene

Subcategory (RNA class) for MIR558 Gene

miRNA

Number of RNA Genes sources:

3 / 14

Aliases for MIR558 Gene

  • MicroRNA 558 2 3 5
  • MIMAT0003222 51
  • Hsa-Mir-558 3
  • Hsa-MiR-558 177
  • MI0003564 51
  • MIRN558 3
  • RF01021 172
  • MIR558 2

External Ids for MIR558 Gene

Previous HGNC Symbols for MIR558 Gene

  • MIRN558

Previous GeneCards Identifiers for MIR558 Gene

  • GC02U901570
  • GC02P032612
  • GC02P032757

Summaries for MIR558 Gene

Entrez Gene Summary for MIR558 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR558 Gene

MIR558 (MicroRNA 558) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR558 Gene

Additional gene information for MIR558 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR558 Gene

Genomics for MIR558 Gene

GeneHancer (GH) Regulatory Elements for MIR558 Gene

Promoters and enhancers for MIR558 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J032533 Enhancer 0.4 Ensembl 500.7 +1.0 1048 0.4 ZNF316 MAFF MAFK EMSY MIR558 TTC27 ENSG00000274159 BIRC6
GH02J032421 Enhancer 1 Ensembl ENCODE 11.4 -106.8 -106752 8.4 ZSCAN5C ZNF639 ZNF10 OSR2 ZNF316 FOXA2 MAFF MAFK CEBPB POLR2A TTC27 BIRC6 MIR558 NLRC4 DPY30 NONHSAG027423.2 BIRC6-AS1
GH02J032646 Enhancer 0.8 Ensembl ENCODE 10.8 +115.1 115081 1.4 JUND FOS ZNF316 CEBPG FOSL1 EZH2 MAFK ATF4 DPF2 MEIS2 TTC27 MIR558 BIRC6 MIR4765 lnc-BIRC6-3
GH02J032288 Enhancer 0.9 ENCODE 9.7 -242.7 -242691 2.2 FOS TCF7 ZBTB25 TOE1 EP300 SMARCC2 TEAD1 ATF2 ZKSCAN8 ZSCAN9 NLRC4 BIRC6 RNU6-647P MIR558 TTC27 piR-56759-300 piR-43325-051 YIPF4
GH02J032558 Enhancer 0.7 Ensembl 11.6 +28.0 28047 4 GTF2E2 TRIM24 FOS CEBPG POLR2H RBM22 ATF4 MEIS2 POLR2A ZNF175 TTC27 MIR558 BIRC6 DPY30 ENSG00000272716 ENSG00000279544 piR-57460-370 BIRC6-AS2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR558 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR558 Gene

Genomic Locations for MIR558 Gene
chr2:32,532,153-32,532,246
(GRCh38/hg38)
Size:
94 bases
Orientation:
Plus strand
chr2:32,757,220-32,757,313
(GRCh37/hg19)
Size:
94 bases
Orientation:
Plus strand

Genomic View for MIR558 Gene

Genes around MIR558 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR558 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR558 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR558 Gene

Proteins for MIR558 Gene

Post-translational modifications for MIR558 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR558 Gene

Domains & Families for MIR558 Gene

Gene Families for MIR558 Gene

HGNC:
genes like me logo Genes that share domains with MIR558: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR558 Gene

Function for MIR558 Gene

Phenotypes From GWAS Catalog for MIR558 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR558 Gene

Localization for MIR558 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR558 gene
Compartment Confidence
plasma membrane 1
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR558 Gene

Pathways & Interactions for MIR558 Gene

PathCards logo

SuperPathways for MIR558 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR558 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR558 Gene

Drugs & Compounds for MIR558 Gene

No Compound Related Data Available

Transcripts for MIR558 Gene

mRNA/cDNA for MIR558 Gene

2 RNACentral transcripts :
1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 miRBase transcripts :
1 Rfam transcripts :
1 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR558 Gene

No ASD Table

Relevant External Links for MIR558 Gene

GeneLoc Exon Structure for
MIR558

Expression for MIR558 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR558 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR558

genes like me logo Genes that share expression patterns with MIR558: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR558 Gene

Orthologs for MIR558 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR558 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-558 31
  • 99 (a)
OneToOne
Species where no ortholog for MIR558 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR558 Gene

ENSEMBL:
Gene Tree for MIR558 (if available)
TreeFam:
Gene Tree for MIR558 (if available)

Paralogs for MIR558 Gene

No data available for Paralogs for MIR558 Gene

Variants for MIR558 Gene

Additional dbSNP identifiers (rs#s) for MIR558 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR558 Gene

Variant ID Type Subtype PubMed ID
dgv1109e212 CNV gain 25503493
dgv3749n100 CNV gain 25217958
dgv443n27 CNV gain 19166990
dgv6750n54 CNV gain 21841781
esv2422335 CNV duplication 17116639
esv2422472 CNV duplication 17116639
esv2751888 CNV gain 17911159
esv2763243 CNV gain 21179565
esv3590249 CNV gain 21293372
esv3590251 CNV gain 21293372
esv3590254 CNV gain 21293372
nsv456108 CNV gain 19166990
nsv470447 CNV loss 18288195
nsv470448 CNV gain 18288195
nsv516173 CNV gain+loss 19592680
nsv581274 CNV gain 21841781
nsv581281 CNV gain 21841781
nsv833681 CNV gain+loss 17160897
nsv833692 CNV loss 17160897

Additional Variant Information for MIR558 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR558

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR558 Gene

Disorders for MIR558 Gene

Additional Disease Information for MIR558

No disorders were found for MIR558 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR558 Gene

Publications for MIR558 Gene

  1. CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells. (PMID: 28794202) Li Y … Jiang G (EMBO reports 2017) 3 54
  2. Downregulation of AATK mediates microRNA-558-induced resistance of A549 cells to radiotherapy. (PMID: 27485693) Zhu RX … Liu SH (Molecular medicine reports 2016) 3 54
  3. microRNA-558 facilitates the expression of hypoxia-inducible factor 2 alpha through binding to 5'-untranslated region in neuroblastoma. (PMID: 27276678) Qu H … Tong Q (Oncotarget 2016) 3 54
  4. miRNA-558 promotes gastric cancer progression through attenuating Smad4-mediated repression of heparanase expression. (PMID: 27685626) Zheng L … Tong Q (Cell death & disease 2016) 3 54
  5. miRNA-558 promotes tumorigenesis and aggressiveness of neuroblastoma cells through activating the transcription of heparanase. (PMID: 25616966) Qu H … Tong Q (Human molecular genetics 2015) 3 54

Products for MIR558 Gene

Sources for MIR558 Gene